Scaling of Haversian canal surface area to secondary osteon bone volume in ribs and limb bones

TY - JOUR

T1 - Scaling of Haversian canal surface area to secondary osteon bone volume in ribs and limb bones

AU - Skedros, John G

AU - Knight, Alex N

AU - Clark, Gunnar C

AU - Crowder, Christian M

AU - Dominguez, Victoria M

AU - Qiu, Shijing

AU - Mulhern, Dawn M

AU - Donahue, Seth W

AU - Busse, Björn

AU - Hulsey, Brannon I

AU - Zedda, Marco

AU - Sorenson, Scott M

N1 - Copyright © 2013 Wiley Periodicals, Inc.

PY - 2013/6/1

Y1 - 2013/6/1

N2 - Studies of secondary osteons in ribs have provided a great deal of what is known about remodeling dynamics. Compared with limb bones, ribs are metabolically more active and sensitive to hormonal changes, and receive frequent low-strain loading. Optimization for calcium exchange in rib osteons might be achieved without incurring a significant reduction in safety factor by disproportionally increasing central canal size with increased osteon size (positive allometry). By contrast, greater mechanical loads on limb bones might favor reducing deleterious consequences of intracortical porosity by decreasing osteon canal size with increased osteon size (negative allometry). Evidence of this metabolic/mechanical dichotomy between ribs and limb bones was sought by examining relationships between Haversian canal surface area (BS, osteon Haversian canal perimeter, HC.Pm) and bone volume (BV, osteonal wall area, B.Ar) in a broad size range of mature (quiescent) osteons from adult human limb bones and ribs (modern and medieval) and various adult and subadult non-human limb bones and ribs. Reduced major axis (RMA) and least-squares (LS) regressions of HC.Pm/B.Ar data show that rib and limb osteons cannot be distinguished by dimensional allometry of these parameters. Although four of the five rib groups showed positive allometry in terms of the RMA slopes, nearly 50% of the adult limb bone groups also showed positive allometry when negative allometry was expected. Consequently, our results fail to provide clear evidence that BS/BV scaling reflects a rib versus limb bone dichotomy whereby calcium exchange might be preferentially enhanced in rib osteons.

AB - Studies of secondary osteons in ribs have provided a great deal of what is known about remodeling dynamics. Compared with limb bones, ribs are metabolically more active and sensitive to hormonal changes, and receive frequent low-strain loading. Optimization for calcium exchange in rib osteons might be achieved without incurring a significant reduction in safety factor by disproportionally increasing central canal size with increased osteon size (positive allometry). By contrast, greater mechanical loads on limb bones might favor reducing deleterious consequences of intracortical porosity by decreasing osteon canal size with increased osteon size (negative allometry). Evidence of this metabolic/mechanical dichotomy between ribs and limb bones was sought by examining relationships between Haversian canal surface area (BS, osteon Haversian canal perimeter, HC.Pm) and bone volume (BV, osteonal wall area, B.Ar) in a broad size range of mature (quiescent) osteons from adult human limb bones and ribs (modern and medieval) and various adult and subadult non-human limb bones and ribs. Reduced major axis (RMA) and least-squares (LS) regressions of HC.Pm/B.Ar data show that rib and limb osteons cannot be distinguished by dimensional allometry of these parameters. Although four of the five rib groups showed positive allometry in terms of the RMA slopes, nearly 50% of the adult limb bone groups also showed positive allometry when negative allometry was expected. Consequently, our results fail to provide clear evidence that BS/BV scaling reflects a rib versus limb bone dichotomy whereby calcium exchange might be preferentially enhanced in rib osteons.

KW - Adult

KW - Aged

KW - Animals

KW - Anthropology, Physical

KW - Anthropometry

KW - Bone Remodeling

KW - Bone and Bones

KW - Female

KW - Haversian System

KW - Humans

KW - Linear Models

KW - Male

KW - Middle Aged

U2 - 10.1002/ajpa.22270

DO - 10.1002/ajpa.22270

M3 - SCORING: Journal article

C2 - 23633395

VL - 151

SP - 230

EP - 244

JO - AM J PHYS ANTHROPOL

JF - AM J PHYS ANTHROPOL

SN - 0002-9483

IS - 2

ER -