Scaling of Haversian canal surface area to secondary osteon bone volume in ribs and limb bones
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Scaling of Haversian canal surface area to secondary osteon bone volume in ribs and limb bones. / Skedros, John G; Knight, Alex N; Clark, Gunnar C; Crowder, Christian M; Dominguez, Victoria M; Qiu, Shijing; Mulhern, Dawn M; Donahue, Seth W; Busse, Björn; Hulsey, Brannon I; Zedda, Marco; Sorenson, Scott M.
in: AM J PHYS ANTHROPOL, Jahrgang 151, Nr. 2, 01.06.2013, S. 230-44.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Scaling of Haversian canal surface area to secondary osteon bone volume in ribs and limb bones
AU - Skedros, John G
AU - Knight, Alex N
AU - Clark, Gunnar C
AU - Crowder, Christian M
AU - Dominguez, Victoria M
AU - Qiu, Shijing
AU - Mulhern, Dawn M
AU - Donahue, Seth W
AU - Busse, Björn
AU - Hulsey, Brannon I
AU - Zedda, Marco
AU - Sorenson, Scott M
N1 - Copyright © 2013 Wiley Periodicals, Inc.
PY - 2013/6/1
Y1 - 2013/6/1
N2 - Studies of secondary osteons in ribs have provided a great deal of what is known about remodeling dynamics. Compared with limb bones, ribs are metabolically more active and sensitive to hormonal changes, and receive frequent low-strain loading. Optimization for calcium exchange in rib osteons might be achieved without incurring a significant reduction in safety factor by disproportionally increasing central canal size with increased osteon size (positive allometry). By contrast, greater mechanical loads on limb bones might favor reducing deleterious consequences of intracortical porosity by decreasing osteon canal size with increased osteon size (negative allometry). Evidence of this metabolic/mechanical dichotomy between ribs and limb bones was sought by examining relationships between Haversian canal surface area (BS, osteon Haversian canal perimeter, HC.Pm) and bone volume (BV, osteonal wall area, B.Ar) in a broad size range of mature (quiescent) osteons from adult human limb bones and ribs (modern and medieval) and various adult and subadult non-human limb bones and ribs. Reduced major axis (RMA) and least-squares (LS) regressions of HC.Pm/B.Ar data show that rib and limb osteons cannot be distinguished by dimensional allometry of these parameters. Although four of the five rib groups showed positive allometry in terms of the RMA slopes, nearly 50% of the adult limb bone groups also showed positive allometry when negative allometry was expected. Consequently, our results fail to provide clear evidence that BS/BV scaling reflects a rib versus limb bone dichotomy whereby calcium exchange might be preferentially enhanced in rib osteons.
AB - Studies of secondary osteons in ribs have provided a great deal of what is known about remodeling dynamics. Compared with limb bones, ribs are metabolically more active and sensitive to hormonal changes, and receive frequent low-strain loading. Optimization for calcium exchange in rib osteons might be achieved without incurring a significant reduction in safety factor by disproportionally increasing central canal size with increased osteon size (positive allometry). By contrast, greater mechanical loads on limb bones might favor reducing deleterious consequences of intracortical porosity by decreasing osteon canal size with increased osteon size (negative allometry). Evidence of this metabolic/mechanical dichotomy between ribs and limb bones was sought by examining relationships between Haversian canal surface area (BS, osteon Haversian canal perimeter, HC.Pm) and bone volume (BV, osteonal wall area, B.Ar) in a broad size range of mature (quiescent) osteons from adult human limb bones and ribs (modern and medieval) and various adult and subadult non-human limb bones and ribs. Reduced major axis (RMA) and least-squares (LS) regressions of HC.Pm/B.Ar data show that rib and limb osteons cannot be distinguished by dimensional allometry of these parameters. Although four of the five rib groups showed positive allometry in terms of the RMA slopes, nearly 50% of the adult limb bone groups also showed positive allometry when negative allometry was expected. Consequently, our results fail to provide clear evidence that BS/BV scaling reflects a rib versus limb bone dichotomy whereby calcium exchange might be preferentially enhanced in rib osteons.
KW - Adult
KW - Aged
KW - Animals
KW - Anthropology, Physical
KW - Anthropometry
KW - Bone Remodeling
KW - Bone and Bones
KW - Female
KW - Haversian System
KW - Humans
KW - Linear Models
KW - Male
KW - Middle Aged
U2 - 10.1002/ajpa.22270
DO - 10.1002/ajpa.22270
M3 - SCORING: Journal article
C2 - 23633395
VL - 151
SP - 230
EP - 244
JO - AM J PHYS ANTHROPOL
JF - AM J PHYS ANTHROPOL
SN - 0002-9483
IS - 2
ER -