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SARS-CoV-2 Reinfection in a Healthcare Worker Despite the Presence of Detectable Neutralizing Antibodies

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SARS-CoV-2 Reinfection in a Healthcare Worker Despite the Presence of Detectable Neutralizing Antibodies. / Brehm, Thomas Theo; Pfefferle, Susanne; von Possel, Ronald; Kobbe, Robin; Nörz, Dominik; Schmiedel, Stefan; Grundhoff, Adam; Olearo, Flaminia; Emmerich, Petra; Robitaille, Alexis; Günther, Thomas; Braun, Platon; Andersen, Gabriele; Knobloch, Johannes K; Addo, Marylyn M; Lohse, Ansgar W; Aepfelbacher, Martin; Fischer, Nicole; Schulze Zur Wiesch, Julian; Lütgehetmann, Marc.

In: VIRUSES-BASEL, Vol. 13, No. 4, 661, 12.04.2021.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research

Harvard

Brehm, TT, Pfefferle, S, von Possel, R, Kobbe, R, Nörz, D, Schmiedel, S, Grundhoff, A, Olearo, F, Emmerich, P, Robitaille, A, Günther, T, Braun, P, Andersen, G, Knobloch, JK, Addo, MM, Lohse, AW, Aepfelbacher, M, Fischer, N, Schulze Zur Wiesch, J & Lütgehetmann, M 2021, 'SARS-CoV-2 Reinfection in a Healthcare Worker Despite the Presence of Detectable Neutralizing Antibodies', VIRUSES-BASEL, vol. 13, no. 4, 661. https://doi.org/10.3390/v13040661

APA

Brehm, T. T., Pfefferle, S., von Possel, R., Kobbe, R., Nörz, D., Schmiedel, S., Grundhoff, A., Olearo, F., Emmerich, P., Robitaille, A., Günther, T., Braun, P., Andersen, G., Knobloch, J. K., Addo, M. M., Lohse, A. W., Aepfelbacher, M., Fischer, N., Schulze Zur Wiesch, J., & Lütgehetmann, M. (2021). SARS-CoV-2 Reinfection in a Healthcare Worker Despite the Presence of Detectable Neutralizing Antibodies. VIRUSES-BASEL, 13(4), [661]. https://doi.org/10.3390/v13040661

Vancouver

Brehm TT, Pfefferle S, von Possel R, Kobbe R, Nörz D, Schmiedel S et al. SARS-CoV-2 Reinfection in a Healthcare Worker Despite the Presence of Detectable Neutralizing Antibodies. VIRUSES-BASEL. 2021 Apr 12;13(4). 661. https://doi.org/10.3390/v13040661

Bibtex

@article{a7f9c4381d6b412dbb3809a4e94f013a,
title = "SARS-CoV-2 Reinfection in a Healthcare Worker Despite the Presence of Detectable Neutralizing Antibodies",
abstract = "So far, only a few reports about reinfections with SARS-CoV-2 have been published, and they often lack detailed immunological and virological data. We report about a SARS-CoV-2 reinfection with a genetically distinct SARS-CoV-2 variant in an immunocompetent female healthcare worker that has led to a mild disease course. No obvious viral escape mutations were observed in the second virus variant. The infectious virus was shed from the patient during the second infection episode despite the presence of neutralizing antibodies in her blood. Our data indicate that a moderate immune response after the first infection, but not a viral escape, did allow for reinfection and live virus shedding.",
author = "Brehm, {Thomas Theo} and Susanne Pfefferle and {von Possel}, Ronald and Robin Kobbe and Dominik N{\"o}rz and Stefan Schmiedel and Adam Grundhoff and Flaminia Olearo and Petra Emmerich and Alexis Robitaille and Thomas G{\"u}nther and Platon Braun and Gabriele Andersen and Knobloch, {Johannes K} and Addo, {Marylyn M} and Lohse, {Ansgar W} and Martin Aepfelbacher and Nicole Fischer and {Schulze Zur Wiesch}, Julian and Marc L{\"u}tgehetmann",
year = "2021",
month = apr,
day = "12",
doi = "10.3390/v13040661",
language = "English",
volume = "13",
journal = "VIRUSES-BASEL",
issn = "1999-4915",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "4",

}

RIS

TY - JOUR

T1 - SARS-CoV-2 Reinfection in a Healthcare Worker Despite the Presence of Detectable Neutralizing Antibodies

AU - Brehm, Thomas Theo

AU - Pfefferle, Susanne

AU - von Possel, Ronald

AU - Kobbe, Robin

AU - Nörz, Dominik

AU - Schmiedel, Stefan

AU - Grundhoff, Adam

AU - Olearo, Flaminia

AU - Emmerich, Petra

AU - Robitaille, Alexis

AU - Günther, Thomas

AU - Braun, Platon

AU - Andersen, Gabriele

AU - Knobloch, Johannes K

AU - Addo, Marylyn M

AU - Lohse, Ansgar W

AU - Aepfelbacher, Martin

AU - Fischer, Nicole

AU - Schulze Zur Wiesch, Julian

AU - Lütgehetmann, Marc

PY - 2021/4/12

Y1 - 2021/4/12

N2 - So far, only a few reports about reinfections with SARS-CoV-2 have been published, and they often lack detailed immunological and virological data. We report about a SARS-CoV-2 reinfection with a genetically distinct SARS-CoV-2 variant in an immunocompetent female healthcare worker that has led to a mild disease course. No obvious viral escape mutations were observed in the second virus variant. The infectious virus was shed from the patient during the second infection episode despite the presence of neutralizing antibodies in her blood. Our data indicate that a moderate immune response after the first infection, but not a viral escape, did allow for reinfection and live virus shedding.

AB - So far, only a few reports about reinfections with SARS-CoV-2 have been published, and they often lack detailed immunological and virological data. We report about a SARS-CoV-2 reinfection with a genetically distinct SARS-CoV-2 variant in an immunocompetent female healthcare worker that has led to a mild disease course. No obvious viral escape mutations were observed in the second virus variant. The infectious virus was shed from the patient during the second infection episode despite the presence of neutralizing antibodies in her blood. Our data indicate that a moderate immune response after the first infection, but not a viral escape, did allow for reinfection and live virus shedding.

U2 - 10.3390/v13040661

DO - 10.3390/v13040661

M3 - SCORING: Journal article

C2 - 33921216

VL - 13

JO - VIRUSES-BASEL

JF - VIRUSES-BASEL

SN - 1999-4915

IS - 4

M1 - 661

ER -