SARS-CoV-2 Reinfection in a Healthcare Worker Despite the Presence of Detectable Neutralizing Antibodies
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SARS-CoV-2 Reinfection in a Healthcare Worker Despite the Presence of Detectable Neutralizing Antibodies. / Brehm, Thomas Theo; Pfefferle, Susanne; von Possel, Ronald; Kobbe, Robin; Nörz, Dominik; Schmiedel, Stefan; Grundhoff, Adam; Olearo, Flaminia; Emmerich, Petra; Robitaille, Alexis; Günther, Thomas; Braun, Platon; Andersen, Gabriele; Knobloch, Johannes K; Addo, Marylyn M; Lohse, Ansgar W; Aepfelbacher, Martin; Fischer, Nicole; Schulze Zur Wiesch, Julian; Lütgehetmann, Marc.
in: VIRUSES-BASEL, Jahrgang 13, Nr. 4, 661, 12.04.2021.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung
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TY - JOUR
T1 - SARS-CoV-2 Reinfection in a Healthcare Worker Despite the Presence of Detectable Neutralizing Antibodies
AU - Brehm, Thomas Theo
AU - Pfefferle, Susanne
AU - von Possel, Ronald
AU - Kobbe, Robin
AU - Nörz, Dominik
AU - Schmiedel, Stefan
AU - Grundhoff, Adam
AU - Olearo, Flaminia
AU - Emmerich, Petra
AU - Robitaille, Alexis
AU - Günther, Thomas
AU - Braun, Platon
AU - Andersen, Gabriele
AU - Knobloch, Johannes K
AU - Addo, Marylyn M
AU - Lohse, Ansgar W
AU - Aepfelbacher, Martin
AU - Fischer, Nicole
AU - Schulze Zur Wiesch, Julian
AU - Lütgehetmann, Marc
PY - 2021/4/12
Y1 - 2021/4/12
N2 - So far, only a few reports about reinfections with SARS-CoV-2 have been published, and they often lack detailed immunological and virological data. We report about a SARS-CoV-2 reinfection with a genetically distinct SARS-CoV-2 variant in an immunocompetent female healthcare worker that has led to a mild disease course. No obvious viral escape mutations were observed in the second virus variant. The infectious virus was shed from the patient during the second infection episode despite the presence of neutralizing antibodies in her blood. Our data indicate that a moderate immune response after the first infection, but not a viral escape, did allow for reinfection and live virus shedding.
AB - So far, only a few reports about reinfections with SARS-CoV-2 have been published, and they often lack detailed immunological and virological data. We report about a SARS-CoV-2 reinfection with a genetically distinct SARS-CoV-2 variant in an immunocompetent female healthcare worker that has led to a mild disease course. No obvious viral escape mutations were observed in the second virus variant. The infectious virus was shed from the patient during the second infection episode despite the presence of neutralizing antibodies in her blood. Our data indicate that a moderate immune response after the first infection, but not a viral escape, did allow for reinfection and live virus shedding.
U2 - 10.3390/v13040661
DO - 10.3390/v13040661
M3 - SCORING: Journal article
C2 - 33921216
VL - 13
JO - VIRUSES-BASEL
JF - VIRUSES-BASEL
SN - 1999-4915
IS - 4
M1 - 661
ER -