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SARS-CoV-2 outbreak investigation in a German meat processing plant

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SARS-CoV-2 outbreak investigation in a German meat processing plant. / Günther, Thomas; Czech-Sioli, Manja; Indenbirken, Daniela; Robitaille, Alexis; Tenhaken, Peter; Exner, Martin; Ottinger, Matthias; Fischer, Nicole; Grundhoff, Adam; Brinkmann, Melanie M.

In: EMBO MOL MED, Vol. 12, No. 12, 07.12.2020, p. e13296.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Günther, T, Czech-Sioli, M, Indenbirken, D, Robitaille, A, Tenhaken, P, Exner, M, Ottinger, M, Fischer, N, Grundhoff, A & Brinkmann, MM 2020, 'SARS-CoV-2 outbreak investigation in a German meat processing plant', EMBO MOL MED, vol. 12, no. 12, pp. e13296. https://doi.org/10.15252/emmm.202013296

APA

Günther, T., Czech-Sioli, M., Indenbirken, D., Robitaille, A., Tenhaken, P., Exner, M., Ottinger, M., Fischer, N., Grundhoff, A., & Brinkmann, M. M. (2020). SARS-CoV-2 outbreak investigation in a German meat processing plant. EMBO MOL MED, 12(12), e13296. https://doi.org/10.15252/emmm.202013296

Vancouver

Günther T, Czech-Sioli M, Indenbirken D, Robitaille A, Tenhaken P, Exner M et al. SARS-CoV-2 outbreak investigation in a German meat processing plant. EMBO MOL MED. 2020 Dec 7;12(12):e13296. https://doi.org/10.15252/emmm.202013296

Bibtex

@article{58a3df68d8b248febfaac8f3a9177272,
title = "SARS-CoV-2 outbreak investigation in a German meat processing plant",
abstract = "We describe a multifactorial investigation of a SARS-CoV-2 outbreak in a large meat processing complex in Germany. Infection event timing, spatial, climate and ventilation conditions in the processing plant, sharing of living quarters and transport, and viral genome sequences were analyzed. Our results suggest that a single index case transmitted SARS-CoV-2 to co-workers over distances of more than 8 m, within a confined work area in which air is constantly recirculated and cooled. Viral genome sequencing shows that all cases share a set of mutations representing a novel sub-branch in the SARS-CoV-2 C20 clade. We identified the same set of mutations in samples collected in the time period between this initial infection cluster and a subsequent outbreak within the same factory, with the largest number of confirmed SARS-CoV-2 cases in a German meat processing facility reported so far. Our results indicate climate conditions, fresh air exchange rates, and airflow as factors that can promote efficient spread of SARS-CoV-2 via long distances and provide insights into possible requirements for pandemic mitigation strategies in industrial workplace settings.",
author = "Thomas G{\"u}nther and Manja Czech-Sioli and Daniela Indenbirken and Alexis Robitaille and Peter Tenhaken and Martin Exner and Matthias Ottinger and Nicole Fischer and Adam Grundhoff and Brinkmann, {Melanie M}",
note = "{\textcopyright} 2020 The Authors Published under the terms of the CC BY 4.0 license.",
year = "2020",
month = dec,
day = "7",
doi = "10.15252/emmm.202013296",
language = "English",
volume = "12",
pages = "e13296",
journal = "EMBO MOL MED",
issn = "1757-4676",
publisher = "Wiley-Blackwell",
number = "12",

}

RIS

TY - JOUR

T1 - SARS-CoV-2 outbreak investigation in a German meat processing plant

AU - Günther, Thomas

AU - Czech-Sioli, Manja

AU - Indenbirken, Daniela

AU - Robitaille, Alexis

AU - Tenhaken, Peter

AU - Exner, Martin

AU - Ottinger, Matthias

AU - Fischer, Nicole

AU - Grundhoff, Adam

AU - Brinkmann, Melanie M

N1 - © 2020 The Authors Published under the terms of the CC BY 4.0 license.

PY - 2020/12/7

Y1 - 2020/12/7

N2 - We describe a multifactorial investigation of a SARS-CoV-2 outbreak in a large meat processing complex in Germany. Infection event timing, spatial, climate and ventilation conditions in the processing plant, sharing of living quarters and transport, and viral genome sequences were analyzed. Our results suggest that a single index case transmitted SARS-CoV-2 to co-workers over distances of more than 8 m, within a confined work area in which air is constantly recirculated and cooled. Viral genome sequencing shows that all cases share a set of mutations representing a novel sub-branch in the SARS-CoV-2 C20 clade. We identified the same set of mutations in samples collected in the time period between this initial infection cluster and a subsequent outbreak within the same factory, with the largest number of confirmed SARS-CoV-2 cases in a German meat processing facility reported so far. Our results indicate climate conditions, fresh air exchange rates, and airflow as factors that can promote efficient spread of SARS-CoV-2 via long distances and provide insights into possible requirements for pandemic mitigation strategies in industrial workplace settings.

AB - We describe a multifactorial investigation of a SARS-CoV-2 outbreak in a large meat processing complex in Germany. Infection event timing, spatial, climate and ventilation conditions in the processing plant, sharing of living quarters and transport, and viral genome sequences were analyzed. Our results suggest that a single index case transmitted SARS-CoV-2 to co-workers over distances of more than 8 m, within a confined work area in which air is constantly recirculated and cooled. Viral genome sequencing shows that all cases share a set of mutations representing a novel sub-branch in the SARS-CoV-2 C20 clade. We identified the same set of mutations in samples collected in the time period between this initial infection cluster and a subsequent outbreak within the same factory, with the largest number of confirmed SARS-CoV-2 cases in a German meat processing facility reported so far. Our results indicate climate conditions, fresh air exchange rates, and airflow as factors that can promote efficient spread of SARS-CoV-2 via long distances and provide insights into possible requirements for pandemic mitigation strategies in industrial workplace settings.

U2 - 10.15252/emmm.202013296

DO - 10.15252/emmm.202013296

M3 - SCORING: Journal article

C2 - 33012091

VL - 12

SP - e13296

JO - EMBO MOL MED

JF - EMBO MOL MED

SN - 1757-4676

IS - 12

ER -