SARS-CoV-2 outbreak investigation in a German meat processing plant
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SARS-CoV-2 outbreak investigation in a German meat processing plant. / Günther, Thomas; Czech-Sioli, Manja; Indenbirken, Daniela; Robitaille, Alexis; Tenhaken, Peter; Exner, Martin; Ottinger, Matthias; Fischer, Nicole; Grundhoff, Adam; Brinkmann, Melanie M.
in: EMBO MOL MED, Jahrgang 12, Nr. 12, 07.12.2020, S. e13296.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - SARS-CoV-2 outbreak investigation in a German meat processing plant
AU - Günther, Thomas
AU - Czech-Sioli, Manja
AU - Indenbirken, Daniela
AU - Robitaille, Alexis
AU - Tenhaken, Peter
AU - Exner, Martin
AU - Ottinger, Matthias
AU - Fischer, Nicole
AU - Grundhoff, Adam
AU - Brinkmann, Melanie M
N1 - © 2020 The Authors Published under the terms of the CC BY 4.0 license.
PY - 2020/12/7
Y1 - 2020/12/7
N2 - We describe a multifactorial investigation of a SARS-CoV-2 outbreak in a large meat processing complex in Germany. Infection event timing, spatial, climate and ventilation conditions in the processing plant, sharing of living quarters and transport, and viral genome sequences were analyzed. Our results suggest that a single index case transmitted SARS-CoV-2 to co-workers over distances of more than 8 m, within a confined work area in which air is constantly recirculated and cooled. Viral genome sequencing shows that all cases share a set of mutations representing a novel sub-branch in the SARS-CoV-2 C20 clade. We identified the same set of mutations in samples collected in the time period between this initial infection cluster and a subsequent outbreak within the same factory, with the largest number of confirmed SARS-CoV-2 cases in a German meat processing facility reported so far. Our results indicate climate conditions, fresh air exchange rates, and airflow as factors that can promote efficient spread of SARS-CoV-2 via long distances and provide insights into possible requirements for pandemic mitigation strategies in industrial workplace settings.
AB - We describe a multifactorial investigation of a SARS-CoV-2 outbreak in a large meat processing complex in Germany. Infection event timing, spatial, climate and ventilation conditions in the processing plant, sharing of living quarters and transport, and viral genome sequences were analyzed. Our results suggest that a single index case transmitted SARS-CoV-2 to co-workers over distances of more than 8 m, within a confined work area in which air is constantly recirculated and cooled. Viral genome sequencing shows that all cases share a set of mutations representing a novel sub-branch in the SARS-CoV-2 C20 clade. We identified the same set of mutations in samples collected in the time period between this initial infection cluster and a subsequent outbreak within the same factory, with the largest number of confirmed SARS-CoV-2 cases in a German meat processing facility reported so far. Our results indicate climate conditions, fresh air exchange rates, and airflow as factors that can promote efficient spread of SARS-CoV-2 via long distances and provide insights into possible requirements for pandemic mitigation strategies in industrial workplace settings.
U2 - 10.15252/emmm.202013296
DO - 10.15252/emmm.202013296
M3 - SCORING: Journal article
C2 - 33012091
VL - 12
SP - e13296
JO - EMBO MOL MED
JF - EMBO MOL MED
SN - 1757-4676
IS - 12
ER -