Sarcopenia - Endocrinological and Neurological Aspects
Standard
Sarcopenia - Endocrinological and Neurological Aspects. / Stangl, Michaela Katja; Böcker, Wolfgang; Chubanov, Vladimir; Ferrari, Uta; Fischereder, Michael; Gudermann, Thomas; Hesse, Eric; Meinke, Peter; Reincke, Martin; Reisch, Nicole; Saller, Maximilian M; Seissler, Jochen; Schmidmaier, Ralf; Schoser, Benedikt; Then, Cornelia; Thorand, Barbara; Drey, Michael.
In: EXP CLIN ENDOCR DIAB, Vol. 127, No. 1, 01.2019, p. 8-22.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Sarcopenia - Endocrinological and Neurological Aspects
AU - Stangl, Michaela Katja
AU - Böcker, Wolfgang
AU - Chubanov, Vladimir
AU - Ferrari, Uta
AU - Fischereder, Michael
AU - Gudermann, Thomas
AU - Hesse, Eric
AU - Meinke, Peter
AU - Reincke, Martin
AU - Reisch, Nicole
AU - Saller, Maximilian M
AU - Seissler, Jochen
AU - Schmidmaier, Ralf
AU - Schoser, Benedikt
AU - Then, Cornelia
AU - Thorand, Barbara
AU - Drey, Michael
N1 - © Georg Thieme Verlag KG Stuttgart · New York.
PY - 2019/1
Y1 - 2019/1
N2 - Sarcopenia in geriatric patients is often associated with or even caused by changes of the endocrine and nervous system. The multifactorial pathogenesis of sarcopenia and additional multimorbidity in geriatric patients makes it difficult to study distinct pathogenic pathways leading to sarcopenia. Patients suffering from diabetes, Cushing's syndrome, chronic kidney disease, Klinefelter's syndrome or motor neuron diseases, such as amyotrophic lateral sclerosis for example are known to have impaired muscle property and reduced physical performance. These patients are typically younger and suffer from conditions caused by a known molecular disease mechanism and a peculiar sarcopenic phenotype. Therefore, these sequelae can serve as prototypic disease models to study isolated endocrinological and neurodegenerative causes for sarcopenia. This review focuses on diseases whose etiopathogenesis of muscle impairment is known. The idea is to use these diseases as proof of principles to develop a classification algorithm of sarcopenia in the elderly to make a more mechanism-oriented therapy be possible.
AB - Sarcopenia in geriatric patients is often associated with or even caused by changes of the endocrine and nervous system. The multifactorial pathogenesis of sarcopenia and additional multimorbidity in geriatric patients makes it difficult to study distinct pathogenic pathways leading to sarcopenia. Patients suffering from diabetes, Cushing's syndrome, chronic kidney disease, Klinefelter's syndrome or motor neuron diseases, such as amyotrophic lateral sclerosis for example are known to have impaired muscle property and reduced physical performance. These patients are typically younger and suffer from conditions caused by a known molecular disease mechanism and a peculiar sarcopenic phenotype. Therefore, these sequelae can serve as prototypic disease models to study isolated endocrinological and neurodegenerative causes for sarcopenia. This review focuses on diseases whose etiopathogenesis of muscle impairment is known. The idea is to use these diseases as proof of principles to develop a classification algorithm of sarcopenia in the elderly to make a more mechanism-oriented therapy be possible.
KW - Journal Article
KW - Sarcopenia/diagnosis
KW - Animals
KW - Klinefelter Syndrome/complications
KW - Humans
KW - Cushing Syndrome/complications
KW - Renal Insufficiency, Chronic/complications
KW - Amyotrophic Lateral Sclerosis/complications
KW - Diabetes Mellitus, Type 2/complications
U2 - 10.1055/a-0672-1007
DO - 10.1055/a-0672-1007
M3 - SCORING: Review article
C2 - 30199918
VL - 127
SP - 8
EP - 22
JO - EXP CLIN ENDOCR DIAB
JF - EXP CLIN ENDOCR DIAB
SN - 0947-7349
IS - 1
ER -