Salvagebehandlung fortgeschrittener Plattenepithel-karzinome der Mundhöhle und des Oropharynx. Ergebnisse der interstitiellen HDR-Brachytherapie in Kombination mit ablativer Tumorchirurgie

TY - JOUR

T1 - Salvagebehandlung fortgeschrittener Plattenepithel-karzinome der Mundhöhle und des Oropharynx. Ergebnisse der interstitiellen HDR-Brachytherapie in Kombination mit ablativer Tumorchirurgie

AU - Friedrich, R E

AU - Krüll, A

AU - Schwarz, R

AU - Thurmann, H

AU - Plambeck, K

AU - Schmelzle, R

PY - 1997/10/1

Y1 - 1997/10/1

N2 - PURPOSE: The clinical effect of high-dose-rate (HDR) interstitial brachytherapy combined with tumor resection was investigated in this retrospective study on patients with recurrent oral and oropharyngeal squamous cell carcinoma.PATIENTS AND METHODS: Oral and oropharyngeal squamous cell carcinoma in 38 patients were treated over a period of 7 years (1988-1994) by HDR interstitial brachytherapy using Gammamed 12i equipment. Pretreatment of patients in terms of irradiation and surgery differed (33 irradiated with a total dose between 60.0 and 75.6 Gy, including 8 patients with additional surgery; 1 patient with surgery alone, and 4 patients without any pretreatment). Indications for interstitial brachytherapy differed according to individual responses to treatment and medical histories.RESULTS: Interstitial brachytherapy was successful in the majority of patients, i.e. complete remission: 12, partial remission: 19, no change: 2, progression: 5. Local control and overall survival including patients with surgical treatment was 59% and 81% at 6 months and 47% and 49% after 12 months, respectively.CONCLUSION: Interstitial HDR brachytherapy with Iridium 192 is recommended in patients with local recurrences or second primary carcinomas after previous external radiotherapy in the head and neck region. Combination of interstitial brachytherapy and surgery is preferable for these patients.

AB - PURPOSE: The clinical effect of high-dose-rate (HDR) interstitial brachytherapy combined with tumor resection was investigated in this retrospective study on patients with recurrent oral and oropharyngeal squamous cell carcinoma.PATIENTS AND METHODS: Oral and oropharyngeal squamous cell carcinoma in 38 patients were treated over a period of 7 years (1988-1994) by HDR interstitial brachytherapy using Gammamed 12i equipment. Pretreatment of patients in terms of irradiation and surgery differed (33 irradiated with a total dose between 60.0 and 75.6 Gy, including 8 patients with additional surgery; 1 patient with surgery alone, and 4 patients without any pretreatment). Indications for interstitial brachytherapy differed according to individual responses to treatment and medical histories.RESULTS: Interstitial brachytherapy was successful in the majority of patients, i.e. complete remission: 12, partial remission: 19, no change: 2, progression: 5. Local control and overall survival including patients with surgical treatment was 59% and 81% at 6 months and 47% and 49% after 12 months, respectively.CONCLUSION: Interstitial HDR brachytherapy with Iridium 192 is recommended in patients with local recurrences or second primary carcinomas after previous external radiotherapy in the head and neck region. Combination of interstitial brachytherapy and surgery is preferable for these patients.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Brachytherapy

KW - Carcinoma, Squamous Cell

KW - Combined Modality Therapy

KW - Female

KW - Humans

KW - Iridium Radioisotopes

KW - Male

KW - Middle Aged

KW - Mouth Neoplasms

KW - Neoplasm Recurrence, Local

KW - Neoplasms, Second Primary

KW - Oropharyngeal Neoplasms

KW - Radiotherapy Dosage

KW - Retrospective Studies

KW - Salvage Therapy

KW - Time Factors

M3 - SCORING: Zeitschriftenaufsatz

C2 - 9381359

VL - 173

SP - 507

EP - 512

JO - STRAHLENTHER ONKOL

JF - STRAHLENTHER ONKOL

SN - 0179-7158

IS - 10

ER -