Salvagebehandlung fortgeschrittener Plattenepithel-karzinome der Mundhöhle und des Oropharynx. Ergebnisse der interstitiellen HDR-Brachytherapie in Kombination mit ablativer Tumorchirurgie
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Salvagebehandlung fortgeschrittener Plattenepithel-karzinome der Mundhöhle und des Oropharynx. Ergebnisse der interstitiellen HDR-Brachytherapie in Kombination mit ablativer Tumorchirurgie. / Friedrich, R E; Krüll, A; Schwarz, R; Thurmann, H; Plambeck, K; Schmelzle, R.
in: STRAHLENTHER ONKOL, Jahrgang 173, Nr. 10, 01.10.1997, S. 507-12.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Salvagebehandlung fortgeschrittener Plattenepithel-karzinome der Mundhöhle und des Oropharynx. Ergebnisse der interstitiellen HDR-Brachytherapie in Kombination mit ablativer Tumorchirurgie
AU - Friedrich, R E
AU - Krüll, A
AU - Schwarz, R
AU - Thurmann, H
AU - Plambeck, K
AU - Schmelzle, R
PY - 1997/10/1
Y1 - 1997/10/1
N2 - PURPOSE: The clinical effect of high-dose-rate (HDR) interstitial brachytherapy combined with tumor resection was investigated in this retrospective study on patients with recurrent oral and oropharyngeal squamous cell carcinoma.PATIENTS AND METHODS: Oral and oropharyngeal squamous cell carcinoma in 38 patients were treated over a period of 7 years (1988-1994) by HDR interstitial brachytherapy using Gammamed 12i equipment. Pretreatment of patients in terms of irradiation and surgery differed (33 irradiated with a total dose between 60.0 and 75.6 Gy, including 8 patients with additional surgery; 1 patient with surgery alone, and 4 patients without any pretreatment). Indications for interstitial brachytherapy differed according to individual responses to treatment and medical histories.RESULTS: Interstitial brachytherapy was successful in the majority of patients, i.e. complete remission: 12, partial remission: 19, no change: 2, progression: 5. Local control and overall survival including patients with surgical treatment was 59% and 81% at 6 months and 47% and 49% after 12 months, respectively.CONCLUSION: Interstitial HDR brachytherapy with Iridium 192 is recommended in patients with local recurrences or second primary carcinomas after previous external radiotherapy in the head and neck region. Combination of interstitial brachytherapy and surgery is preferable for these patients.
AB - PURPOSE: The clinical effect of high-dose-rate (HDR) interstitial brachytherapy combined with tumor resection was investigated in this retrospective study on patients with recurrent oral and oropharyngeal squamous cell carcinoma.PATIENTS AND METHODS: Oral and oropharyngeal squamous cell carcinoma in 38 patients were treated over a period of 7 years (1988-1994) by HDR interstitial brachytherapy using Gammamed 12i equipment. Pretreatment of patients in terms of irradiation and surgery differed (33 irradiated with a total dose between 60.0 and 75.6 Gy, including 8 patients with additional surgery; 1 patient with surgery alone, and 4 patients without any pretreatment). Indications for interstitial brachytherapy differed according to individual responses to treatment and medical histories.RESULTS: Interstitial brachytherapy was successful in the majority of patients, i.e. complete remission: 12, partial remission: 19, no change: 2, progression: 5. Local control and overall survival including patients with surgical treatment was 59% and 81% at 6 months and 47% and 49% after 12 months, respectively.CONCLUSION: Interstitial HDR brachytherapy with Iridium 192 is recommended in patients with local recurrences or second primary carcinomas after previous external radiotherapy in the head and neck region. Combination of interstitial brachytherapy and surgery is preferable for these patients.
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Brachytherapy
KW - Carcinoma, Squamous Cell
KW - Combined Modality Therapy
KW - Female
KW - Humans
KW - Iridium Radioisotopes
KW - Male
KW - Middle Aged
KW - Mouth Neoplasms
KW - Neoplasm Recurrence, Local
KW - Neoplasms, Second Primary
KW - Oropharyngeal Neoplasms
KW - Radiotherapy Dosage
KW - Retrospective Studies
KW - Salvage Therapy
KW - Time Factors
M3 - SCORING: Zeitschriftenaufsatz
C2 - 9381359
VL - 173
SP - 507
EP - 512
JO - STRAHLENTHER ONKOL
JF - STRAHLENTHER ONKOL
SN - 0179-7158
IS - 10
ER -