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Safety and efficacy of exercise training in various forms of pulmonary hypertension.

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Safety and efficacy of exercise training in various forms of pulmonary hypertension. / Grünig, Ekkehard; Lichtblau, Mona; Ehlken, Nicola; Ghofrani, Hossein A; Reichenberger, Frank; Staehler, Gerd; Halank, Michael; Fischer, Christine; Seyfarth, Hans-Jürgen; Klose, Hans; Meyer, Andreas; Sorichter, Stephan; Wilkens, Heinrike; Rosenkranz, Stephan; Opitz, Christian; Leuchte, Hanno; Karger, Gabriele; Speich, Rudolf; Nagel, Christian.

In: EUR RESPIR J, Vol. 40, No. 1, 1, 2012, p. 84-92.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Grünig, E, Lichtblau, M, Ehlken, N, Ghofrani, HA, Reichenberger, F, Staehler, G, Halank, M, Fischer, C, Seyfarth, H-J, Klose, H, Meyer, A, Sorichter, S, Wilkens, H, Rosenkranz, S, Opitz, C, Leuchte, H, Karger, G, Speich, R & Nagel, C 2012, 'Safety and efficacy of exercise training in various forms of pulmonary hypertension.', EUR RESPIR J, vol. 40, no. 1, 1, pp. 84-92. <http://www.ncbi.nlm.nih.gov/pubmed/22323570?dopt=Citation>

APA

Grünig, E., Lichtblau, M., Ehlken, N., Ghofrani, H. A., Reichenberger, F., Staehler, G., Halank, M., Fischer, C., Seyfarth, H-J., Klose, H., Meyer, A., Sorichter, S., Wilkens, H., Rosenkranz, S., Opitz, C., Leuchte, H., Karger, G., Speich, R., & Nagel, C. (2012). Safety and efficacy of exercise training in various forms of pulmonary hypertension. EUR RESPIR J, 40(1), 84-92. [1]. http://www.ncbi.nlm.nih.gov/pubmed/22323570?dopt=Citation

Vancouver

Grünig E, Lichtblau M, Ehlken N, Ghofrani HA, Reichenberger F, Staehler G et al. Safety and efficacy of exercise training in various forms of pulmonary hypertension. EUR RESPIR J. 2012;40(1):84-92. 1.

Bibtex

@article{0d6ae2684fd54c9286a52e02e708be5d,
title = "Safety and efficacy of exercise training in various forms of pulmonary hypertension.",
abstract = "The objective of this prospective study was to assess safety and efficacy of exercise training in a large cohort of patients with different forms and World Health Organization (WHO) functional classes of chronic pulmonary hypertension (PH). 183 patients with PH (pulmonary arterial hypertension (PAH), chronic thromboembolic PH and PH due to respiratory or left heart diseases received exercise training in hospital for 3 weeks and continued at home. Adverse events have been monitored during the in-hospital training programme. Efficacy parameters were evaluated at baseline, and after 3 and 15 weeks. After 3 and 15 weeks, patients significantly improved the distance walked in 6 min (6MWD) compared to baseline, scores of quality of life, WHO functional class, peak oxygen consumption, oxygen pulse, heart rate and systolic pulmonary artery pressure at rest and maximal workload. The improvement in 6MWD was similar in patients with different PH forms and functional classes. Even in severely affected patients (WHO functional class IV), exercise training was highly effective. Adverse events, such as respiratory infections, syncope or presyncope, occurred in 13% of patients. Exercise training in PH is an effective but not a completely harmless add-on therapy, even in severely diseased patients, and should be closely monitored.",
keywords = "Adult, Humans, Male, Aged, Female, Middle Aged, Aged, 80 and over, Adolescent, Quality of Life, Young Adult, Prospective Studies, Treatment Outcome, Oxygen Consumption, Exercise Therapy/adverse effects/*methods, Hypertension, Pulmonary/physiopathology/*therapy, Walking/physiology, Adult, Humans, Male, Aged, Female, Middle Aged, Aged, 80 and over, Adolescent, Quality of Life, Young Adult, Prospective Studies, Treatment Outcome, Oxygen Consumption, Exercise Therapy/adverse effects/*methods, Hypertension, Pulmonary/physiopathology/*therapy, Walking/physiology",
author = "Ekkehard Gr{\"u}nig and Mona Lichtblau and Nicola Ehlken and Ghofrani, {Hossein A} and Frank Reichenberger and Gerd Staehler and Michael Halank and Christine Fischer and Hans-J{\"u}rgen Seyfarth and Hans Klose and Andreas Meyer and Stephan Sorichter and Heinrike Wilkens and Stephan Rosenkranz and Christian Opitz and Hanno Leuchte and Gabriele Karger and Rudolf Speich and Christian Nagel",
year = "2012",
language = "English",
volume = "40",
pages = "84--92",
journal = "EUR RESPIR J",
issn = "0903-1936",
publisher = "European Respiratory Society",
number = "1",

}

RIS

TY - JOUR

T1 - Safety and efficacy of exercise training in various forms of pulmonary hypertension.

AU - Grünig, Ekkehard

AU - Lichtblau, Mona

AU - Ehlken, Nicola

AU - Ghofrani, Hossein A

AU - Reichenberger, Frank

AU - Staehler, Gerd

AU - Halank, Michael

AU - Fischer, Christine

AU - Seyfarth, Hans-Jürgen

AU - Klose, Hans

AU - Meyer, Andreas

AU - Sorichter, Stephan

AU - Wilkens, Heinrike

AU - Rosenkranz, Stephan

AU - Opitz, Christian

AU - Leuchte, Hanno

AU - Karger, Gabriele

AU - Speich, Rudolf

AU - Nagel, Christian

PY - 2012

Y1 - 2012

N2 - The objective of this prospective study was to assess safety and efficacy of exercise training in a large cohort of patients with different forms and World Health Organization (WHO) functional classes of chronic pulmonary hypertension (PH). 183 patients with PH (pulmonary arterial hypertension (PAH), chronic thromboembolic PH and PH due to respiratory or left heart diseases received exercise training in hospital for 3 weeks and continued at home. Adverse events have been monitored during the in-hospital training programme. Efficacy parameters were evaluated at baseline, and after 3 and 15 weeks. After 3 and 15 weeks, patients significantly improved the distance walked in 6 min (6MWD) compared to baseline, scores of quality of life, WHO functional class, peak oxygen consumption, oxygen pulse, heart rate and systolic pulmonary artery pressure at rest and maximal workload. The improvement in 6MWD was similar in patients with different PH forms and functional classes. Even in severely affected patients (WHO functional class IV), exercise training was highly effective. Adverse events, such as respiratory infections, syncope or presyncope, occurred in 13% of patients. Exercise training in PH is an effective but not a completely harmless add-on therapy, even in severely diseased patients, and should be closely monitored.

AB - The objective of this prospective study was to assess safety and efficacy of exercise training in a large cohort of patients with different forms and World Health Organization (WHO) functional classes of chronic pulmonary hypertension (PH). 183 patients with PH (pulmonary arterial hypertension (PAH), chronic thromboembolic PH and PH due to respiratory or left heart diseases received exercise training in hospital for 3 weeks and continued at home. Adverse events have been monitored during the in-hospital training programme. Efficacy parameters were evaluated at baseline, and after 3 and 15 weeks. After 3 and 15 weeks, patients significantly improved the distance walked in 6 min (6MWD) compared to baseline, scores of quality of life, WHO functional class, peak oxygen consumption, oxygen pulse, heart rate and systolic pulmonary artery pressure at rest and maximal workload. The improvement in 6MWD was similar in patients with different PH forms and functional classes. Even in severely affected patients (WHO functional class IV), exercise training was highly effective. Adverse events, such as respiratory infections, syncope or presyncope, occurred in 13% of patients. Exercise training in PH is an effective but not a completely harmless add-on therapy, even in severely diseased patients, and should be closely monitored.

KW - Adult

KW - Humans

KW - Male

KW - Aged

KW - Female

KW - Middle Aged

KW - Aged, 80 and over

KW - Adolescent

KW - Quality of Life

KW - Young Adult

KW - Prospective Studies

KW - Treatment Outcome

KW - Oxygen Consumption

KW - Exercise Therapy/adverse effects/methods

KW - Hypertension, Pulmonary/physiopathology/therapy

KW - Walking/physiology

KW - Adult

KW - Humans

KW - Male

KW - Aged

KW - Female

KW - Middle Aged

KW - Aged, 80 and over

KW - Adolescent

KW - Quality of Life

KW - Young Adult

KW - Prospective Studies

KW - Treatment Outcome

KW - Oxygen Consumption

KW - Exercise Therapy/adverse effects/methods

KW - Hypertension, Pulmonary/physiopathology/therapy

KW - Walking/physiology

M3 - SCORING: Journal article

VL - 40

SP - 84

EP - 92

JO - EUR RESPIR J

JF - EUR RESPIR J

SN - 0903-1936

IS - 1

M1 - 1

ER -