Safety and efficacy of exercise training in various forms of pulmonary hypertension.
Standard
Safety and efficacy of exercise training in various forms of pulmonary hypertension. / Grünig, Ekkehard; Lichtblau, Mona; Ehlken, Nicola; Ghofrani, Hossein A; Reichenberger, Frank; Staehler, Gerd; Halank, Michael; Fischer, Christine; Seyfarth, Hans-Jürgen; Klose, Hans; Meyer, Andreas; Sorichter, Stephan; Wilkens, Heinrike; Rosenkranz, Stephan; Opitz, Christian; Leuchte, Hanno; Karger, Gabriele; Speich, Rudolf; Nagel, Christian.
in: EUR RESPIR J, Jahrgang 40, Nr. 1, 1, 2012, S. 84-92.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Safety and efficacy of exercise training in various forms of pulmonary hypertension.
AU - Grünig, Ekkehard
AU - Lichtblau, Mona
AU - Ehlken, Nicola
AU - Ghofrani, Hossein A
AU - Reichenberger, Frank
AU - Staehler, Gerd
AU - Halank, Michael
AU - Fischer, Christine
AU - Seyfarth, Hans-Jürgen
AU - Klose, Hans
AU - Meyer, Andreas
AU - Sorichter, Stephan
AU - Wilkens, Heinrike
AU - Rosenkranz, Stephan
AU - Opitz, Christian
AU - Leuchte, Hanno
AU - Karger, Gabriele
AU - Speich, Rudolf
AU - Nagel, Christian
PY - 2012
Y1 - 2012
N2 - The objective of this prospective study was to assess safety and efficacy of exercise training in a large cohort of patients with different forms and World Health Organization (WHO) functional classes of chronic pulmonary hypertension (PH). 183 patients with PH (pulmonary arterial hypertension (PAH), chronic thromboembolic PH and PH due to respiratory or left heart diseases received exercise training in hospital for 3 weeks and continued at home. Adverse events have been monitored during the in-hospital training programme. Efficacy parameters were evaluated at baseline, and after 3 and 15 weeks. After 3 and 15 weeks, patients significantly improved the distance walked in 6 min (6MWD) compared to baseline, scores of quality of life, WHO functional class, peak oxygen consumption, oxygen pulse, heart rate and systolic pulmonary artery pressure at rest and maximal workload. The improvement in 6MWD was similar in patients with different PH forms and functional classes. Even in severely affected patients (WHO functional class IV), exercise training was highly effective. Adverse events, such as respiratory infections, syncope or presyncope, occurred in 13% of patients. Exercise training in PH is an effective but not a completely harmless add-on therapy, even in severely diseased patients, and should be closely monitored.
AB - The objective of this prospective study was to assess safety and efficacy of exercise training in a large cohort of patients with different forms and World Health Organization (WHO) functional classes of chronic pulmonary hypertension (PH). 183 patients with PH (pulmonary arterial hypertension (PAH), chronic thromboembolic PH and PH due to respiratory or left heart diseases received exercise training in hospital for 3 weeks and continued at home. Adverse events have been monitored during the in-hospital training programme. Efficacy parameters were evaluated at baseline, and after 3 and 15 weeks. After 3 and 15 weeks, patients significantly improved the distance walked in 6 min (6MWD) compared to baseline, scores of quality of life, WHO functional class, peak oxygen consumption, oxygen pulse, heart rate and systolic pulmonary artery pressure at rest and maximal workload. The improvement in 6MWD was similar in patients with different PH forms and functional classes. Even in severely affected patients (WHO functional class IV), exercise training was highly effective. Adverse events, such as respiratory infections, syncope or presyncope, occurred in 13% of patients. Exercise training in PH is an effective but not a completely harmless add-on therapy, even in severely diseased patients, and should be closely monitored.
KW - Adult
KW - Humans
KW - Male
KW - Aged
KW - Female
KW - Middle Aged
KW - Aged, 80 and over
KW - Adolescent
KW - Quality of Life
KW - Young Adult
KW - Prospective Studies
KW - Treatment Outcome
KW - Oxygen Consumption
KW - Exercise Therapy/adverse effects/methods
KW - Hypertension, Pulmonary/physiopathology/therapy
KW - Walking/physiology
KW - Adult
KW - Humans
KW - Male
KW - Aged
KW - Female
KW - Middle Aged
KW - Aged, 80 and over
KW - Adolescent
KW - Quality of Life
KW - Young Adult
KW - Prospective Studies
KW - Treatment Outcome
KW - Oxygen Consumption
KW - Exercise Therapy/adverse effects/methods
KW - Hypertension, Pulmonary/physiopathology/therapy
KW - Walking/physiology
M3 - SCORING: Journal article
VL - 40
SP - 84
EP - 92
JO - EUR RESPIR J
JF - EUR RESPIR J
SN - 0903-1936
IS - 1
M1 - 1
ER -