Research ExplorerPublicationsS100A8 and S100A9 in inflammation and cancer

S100A8 and S100A9 in inflammation and cancer

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S100A8 and S100A9 in inflammation and cancer. / Gebhardt, Christoffer; Németh, Julia; Angel, Peter; Hess, Jochen.

In: BIOCHEM PHARMACOL, Vol. 72, No. 11, 30.11.2006, p. 1622-31.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Gebhardt, C, Németh, J, Angel, P & Hess, J 2006, 'S100A8 and S100A9 in inflammation and cancer', BIOCHEM PHARMACOL, vol. 72, no. 11, pp. 1622-31. https://doi.org/10.1016/j.bcp.2006.05.017

APA

Gebhardt, C., Németh, J., Angel, P., & Hess, J. (2006). S100A8 and S100A9 in inflammation and cancer. BIOCHEM PHARMACOL, 72(11), 1622-31. https://doi.org/10.1016/j.bcp.2006.05.017

Vancouver

Gebhardt C, Németh J, Angel P, Hess J. S100A8 and S100A9 in inflammation and cancer. BIOCHEM PHARMACOL. 2006 Nov 30;72(11):1622-31. https://doi.org/10.1016/j.bcp.2006.05.017

Bibtex

@article{87d648324b244252bc7422ee0514b91f,
title = "S100A8 and S100A9 in inflammation and cancer",
abstract = "Calprotectin (S100A8/A9), a heterodimer of the two calcium-binding proteins S100A8 and S100A9, was originally discovered as immunogenic protein expressed and secreted by neutrophils. Subsequently, it has emerged as important pro-inflammatory mediator in acute and chronic inflammation. More recently, increased S100A8 and S100A9 levels were also detected in various human cancers, presenting abundant expression in neoplastic tumor cells as well as infiltrating immune cells. Although, many possible functions have been proposed for S100A8/A9, its biological role still remains to be defined. Altogether, its expression and potential cytokine-like function in inflammation and in cancer suggests that S100A8/A9 may play a key role in inflammation-associated cancer.",
keywords = "Animals, Calgranulin A, Calgranulin B, Carcinoma, Squamous Cell, Humans, Inflammation, Mice, Neutrophils, Skin Neoplasms, Journal Article, Research Support, Non-U.S. Gov't, Review",
author = "Christoffer Gebhardt and Julia N{\'e}meth and Peter Angel and Jochen Hess",
year = "2006",
month = nov,
day = "30",
doi = "10.1016/j.bcp.2006.05.017",
language = "English",
volume = "72",
pages = "1622--31",
journal = "BIOCHEM PHARMACOL",
issn = "0006-2952",
publisher = "Elsevier Inc.",
number = "11",

}

RIS

TY - JOUR

T1 - S100A8 and S100A9 in inflammation and cancer

AU - Gebhardt, Christoffer

AU - Németh, Julia

AU - Angel, Peter

AU - Hess, Jochen

PY - 2006/11/30

Y1 - 2006/11/30

N2 - Calprotectin (S100A8/A9), a heterodimer of the two calcium-binding proteins S100A8 and S100A9, was originally discovered as immunogenic protein expressed and secreted by neutrophils. Subsequently, it has emerged as important pro-inflammatory mediator in acute and chronic inflammation. More recently, increased S100A8 and S100A9 levels were also detected in various human cancers, presenting abundant expression in neoplastic tumor cells as well as infiltrating immune cells. Although, many possible functions have been proposed for S100A8/A9, its biological role still remains to be defined. Altogether, its expression and potential cytokine-like function in inflammation and in cancer suggests that S100A8/A9 may play a key role in inflammation-associated cancer.

AB - Calprotectin (S100A8/A9), a heterodimer of the two calcium-binding proteins S100A8 and S100A9, was originally discovered as immunogenic protein expressed and secreted by neutrophils. Subsequently, it has emerged as important pro-inflammatory mediator in acute and chronic inflammation. More recently, increased S100A8 and S100A9 levels were also detected in various human cancers, presenting abundant expression in neoplastic tumor cells as well as infiltrating immune cells. Although, many possible functions have been proposed for S100A8/A9, its biological role still remains to be defined. Altogether, its expression and potential cytokine-like function in inflammation and in cancer suggests that S100A8/A9 may play a key role in inflammation-associated cancer.

KW - Animals

KW - Calgranulin A

KW - Calgranulin B

KW - Carcinoma, Squamous Cell

KW - Humans

KW - Inflammation

KW - Mice

KW - Neutrophils

KW - Skin Neoplasms

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

KW - Review

U2 - 10.1016/j.bcp.2006.05.017

DO - 10.1016/j.bcp.2006.05.017

M3 - SCORING: Review article

C2 - 16846592

VL - 72

SP - 1622

EP - 1631

JO - BIOCHEM PHARMACOL

JF - BIOCHEM PHARMACOL

SN - 0006-2952

IS - 11

ER -