S100A8 and S100A9 in inflammation and cancer
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S100A8 and S100A9 in inflammation and cancer. / Gebhardt, Christoffer; Németh, Julia; Angel, Peter; Hess, Jochen.
in: BIOCHEM PHARMACOL, Jahrgang 72, Nr. 11, 30.11.2006, S. 1622-31.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
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TY - JOUR
T1 - S100A8 and S100A9 in inflammation and cancer
AU - Gebhardt, Christoffer
AU - Németh, Julia
AU - Angel, Peter
AU - Hess, Jochen
PY - 2006/11/30
Y1 - 2006/11/30
N2 - Calprotectin (S100A8/A9), a heterodimer of the two calcium-binding proteins S100A8 and S100A9, was originally discovered as immunogenic protein expressed and secreted by neutrophils. Subsequently, it has emerged as important pro-inflammatory mediator in acute and chronic inflammation. More recently, increased S100A8 and S100A9 levels were also detected in various human cancers, presenting abundant expression in neoplastic tumor cells as well as infiltrating immune cells. Although, many possible functions have been proposed for S100A8/A9, its biological role still remains to be defined. Altogether, its expression and potential cytokine-like function in inflammation and in cancer suggests that S100A8/A9 may play a key role in inflammation-associated cancer.
AB - Calprotectin (S100A8/A9), a heterodimer of the two calcium-binding proteins S100A8 and S100A9, was originally discovered as immunogenic protein expressed and secreted by neutrophils. Subsequently, it has emerged as important pro-inflammatory mediator in acute and chronic inflammation. More recently, increased S100A8 and S100A9 levels were also detected in various human cancers, presenting abundant expression in neoplastic tumor cells as well as infiltrating immune cells. Although, many possible functions have been proposed for S100A8/A9, its biological role still remains to be defined. Altogether, its expression and potential cytokine-like function in inflammation and in cancer suggests that S100A8/A9 may play a key role in inflammation-associated cancer.
KW - Animals
KW - Calgranulin A
KW - Calgranulin B
KW - Carcinoma, Squamous Cell
KW - Humans
KW - Inflammation
KW - Mice
KW - Neutrophils
KW - Skin Neoplasms
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
KW - Review
U2 - 10.1016/j.bcp.2006.05.017
DO - 10.1016/j.bcp.2006.05.017
M3 - SCORING: Review article
C2 - 16846592
VL - 72
SP - 1622
EP - 1631
JO - BIOCHEM PHARMACOL
JF - BIOCHEM PHARMACOL
SN - 0006-2952
IS - 11
ER -