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Rostral locus coeruleus integrity is associated with better memory performance in older adults

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Rostral locus coeruleus integrity is associated with better memory performance in older adults. / Dahl, Martin J; Mather, Mara; Düzel, Sandra; Bodammer, Nils C; Lindenberger, Ulman; Kühn, Simone; Werkle-Bergner, Markus.

In: NAT HUM BEHAV, Vol. 3, No. 11, 11.2019, p. 1203-1214.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Dahl, MJ, Mather, M, Düzel, S, Bodammer, NC, Lindenberger, U, Kühn, S & Werkle-Bergner, M 2019, 'Rostral locus coeruleus integrity is associated with better memory performance in older adults', NAT HUM BEHAV, vol. 3, no. 11, pp. 1203-1214. https://doi.org/10.1038/s41562-019-0715-2

APA

Dahl, M. J., Mather, M., Düzel, S., Bodammer, N. C., Lindenberger, U., Kühn, S., & Werkle-Bergner, M. (2019). Rostral locus coeruleus integrity is associated with better memory performance in older adults. NAT HUM BEHAV, 3(11), 1203-1214. https://doi.org/10.1038/s41562-019-0715-2

Vancouver

Dahl MJ, Mather M, Düzel S, Bodammer NC, Lindenberger U, Kühn S et al. Rostral locus coeruleus integrity is associated with better memory performance in older adults. NAT HUM BEHAV. 2019 Nov;3(11):1203-1214. https://doi.org/10.1038/s41562-019-0715-2

Bibtex

@article{fc1a7fc6749748e3a484a196f38c9485,
title = "Rostral locus coeruleus integrity is associated with better memory performance in older adults",
abstract = "For decades, research into memory decline in human cognitive ageing has focused on neocortical regions, the hippocampus and dopaminergic neuromodulation. Recent findings indicate that the locus coeruleus (LC) and noradrenergic neuromodulation may also play an important role in shaping memory development in later life. However, technical challenges in quantification of LC integrity have hindered the study of LC-cognition associations in humans. Using high-resolution, neuromelanin-sensitive magnetic resonance imaging, we found that individual differences in learning and memory were positively associated with LC integrity across a variety of memory tasks in both younger (n = 66) and older adults (n = 228). Moreover, we observed functionally relevant age differences confined to rostral LC. Older adults with a more 'youth-like' rostral LC also showed higher memory performance. These findings link non-invasive, in vivo indices of LC integrity to memory in ageing and highlight the role of the LC norepinephrine system in the decline of cognition.",
author = "Dahl, {Martin J} and Mara Mather and Sandra D{\"u}zel and Bodammer, {Nils C} and Ulman Lindenberger and Simone K{\"u}hn and Markus Werkle-Bergner",
year = "2019",
month = nov,
doi = "10.1038/s41562-019-0715-2",
language = "English",
volume = "3",
pages = "1203--1214",
journal = "NAT HUM BEHAV",
issn = "2397-3374",
publisher = "NATURE PUBLISHING GROUP",
number = "11",

}

RIS

TY - JOUR

T1 - Rostral locus coeruleus integrity is associated with better memory performance in older adults

AU - Dahl, Martin J

AU - Mather, Mara

AU - Düzel, Sandra

AU - Bodammer, Nils C

AU - Lindenberger, Ulman

AU - Kühn, Simone

AU - Werkle-Bergner, Markus

PY - 2019/11

Y1 - 2019/11

N2 - For decades, research into memory decline in human cognitive ageing has focused on neocortical regions, the hippocampus and dopaminergic neuromodulation. Recent findings indicate that the locus coeruleus (LC) and noradrenergic neuromodulation may also play an important role in shaping memory development in later life. However, technical challenges in quantification of LC integrity have hindered the study of LC-cognition associations in humans. Using high-resolution, neuromelanin-sensitive magnetic resonance imaging, we found that individual differences in learning and memory were positively associated with LC integrity across a variety of memory tasks in both younger (n = 66) and older adults (n = 228). Moreover, we observed functionally relevant age differences confined to rostral LC. Older adults with a more 'youth-like' rostral LC also showed higher memory performance. These findings link non-invasive, in vivo indices of LC integrity to memory in ageing and highlight the role of the LC norepinephrine system in the decline of cognition.

AB - For decades, research into memory decline in human cognitive ageing has focused on neocortical regions, the hippocampus and dopaminergic neuromodulation. Recent findings indicate that the locus coeruleus (LC) and noradrenergic neuromodulation may also play an important role in shaping memory development in later life. However, technical challenges in quantification of LC integrity have hindered the study of LC-cognition associations in humans. Using high-resolution, neuromelanin-sensitive magnetic resonance imaging, we found that individual differences in learning and memory were positively associated with LC integrity across a variety of memory tasks in both younger (n = 66) and older adults (n = 228). Moreover, we observed functionally relevant age differences confined to rostral LC. Older adults with a more 'youth-like' rostral LC also showed higher memory performance. These findings link non-invasive, in vivo indices of LC integrity to memory in ageing and highlight the role of the LC norepinephrine system in the decline of cognition.

U2 - 10.1038/s41562-019-0715-2

DO - 10.1038/s41562-019-0715-2

M3 - SCORING: Journal article

C2 - 31501542

VL - 3

SP - 1203

EP - 1214

JO - NAT HUM BEHAV

JF - NAT HUM BEHAV

SN - 2397-3374

IS - 11

ER -