Rostral locus coeruleus integrity is associated with better memory performance in older adults
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Rostral locus coeruleus integrity is associated with better memory performance in older adults. / Dahl, Martin J; Mather, Mara; Düzel, Sandra; Bodammer, Nils C; Lindenberger, Ulman; Kühn, Simone; Werkle-Bergner, Markus.
in: NAT HUM BEHAV, Jahrgang 3, Nr. 11, 11.2019, S. 1203-1214.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Rostral locus coeruleus integrity is associated with better memory performance in older adults
AU - Dahl, Martin J
AU - Mather, Mara
AU - Düzel, Sandra
AU - Bodammer, Nils C
AU - Lindenberger, Ulman
AU - Kühn, Simone
AU - Werkle-Bergner, Markus
PY - 2019/11
Y1 - 2019/11
N2 - For decades, research into memory decline in human cognitive ageing has focused on neocortical regions, the hippocampus and dopaminergic neuromodulation. Recent findings indicate that the locus coeruleus (LC) and noradrenergic neuromodulation may also play an important role in shaping memory development in later life. However, technical challenges in quantification of LC integrity have hindered the study of LC-cognition associations in humans. Using high-resolution, neuromelanin-sensitive magnetic resonance imaging, we found that individual differences in learning and memory were positively associated with LC integrity across a variety of memory tasks in both younger (n = 66) and older adults (n = 228). Moreover, we observed functionally relevant age differences confined to rostral LC. Older adults with a more 'youth-like' rostral LC also showed higher memory performance. These findings link non-invasive, in vivo indices of LC integrity to memory in ageing and highlight the role of the LC norepinephrine system in the decline of cognition.
AB - For decades, research into memory decline in human cognitive ageing has focused on neocortical regions, the hippocampus and dopaminergic neuromodulation. Recent findings indicate that the locus coeruleus (LC) and noradrenergic neuromodulation may also play an important role in shaping memory development in later life. However, technical challenges in quantification of LC integrity have hindered the study of LC-cognition associations in humans. Using high-resolution, neuromelanin-sensitive magnetic resonance imaging, we found that individual differences in learning and memory were positively associated with LC integrity across a variety of memory tasks in both younger (n = 66) and older adults (n = 228). Moreover, we observed functionally relevant age differences confined to rostral LC. Older adults with a more 'youth-like' rostral LC also showed higher memory performance. These findings link non-invasive, in vivo indices of LC integrity to memory in ageing and highlight the role of the LC norepinephrine system in the decline of cognition.
U2 - 10.1038/s41562-019-0715-2
DO - 10.1038/s41562-019-0715-2
M3 - SCORING: Journal article
C2 - 31501542
VL - 3
SP - 1203
EP - 1214
JO - NAT HUM BEHAV
JF - NAT HUM BEHAV
SN - 2397-3374
IS - 11
ER -