Role of Survivin expression in predicting biochemical recurrence after radical prostatectomy: a multi-institutional study
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Role of Survivin expression in predicting biochemical recurrence after radical prostatectomy: a multi-institutional study. / Mathieu, Romain; Lucca, Ilaria; Vartolomei, Mihai Dorin; MBeutcha, Aurélie; Klatte, Tobias; Seitz, Christian; Karakiewicz, Pierre I; Fajkovic, Harun; Sun, Maxine; Lotan, Yair; Montorsi, Francesco; Briganti, Alberto; Rouprêt, Morgan; Margulis, Vitaly; Rink, Michael; Rieken, Malte; Kenner, Lukas; Susani, Martin; Wolgang, Loidl; Shariat, Shahrokh F.
In: BJU INT, Vol. 119, No. 2, 02.2017, p. 234-238.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Role of Survivin expression in predicting biochemical recurrence after radical prostatectomy: a multi-institutional study
AU - Mathieu, Romain
AU - Lucca, Ilaria
AU - Vartolomei, Mihai Dorin
AU - MBeutcha, Aurélie
AU - Klatte, Tobias
AU - Seitz, Christian
AU - Karakiewicz, Pierre I
AU - Fajkovic, Harun
AU - Sun, Maxine
AU - Lotan, Yair
AU - Montorsi, Francesco
AU - Briganti, Alberto
AU - Rouprêt, Morgan
AU - Margulis, Vitaly
AU - Rink, Michael
AU - Rieken, Malte
AU - Kenner, Lukas
AU - Susani, Martin
AU - Wolgang, Loidl
AU - Shariat, Shahrokh F
N1 - This article is protected by copyright. All rights reserved.
PY - 2017/2
Y1 - 2017/2
N2 - OBJECTIVE: To assess the association of Survivin expression with clinicopathological features and biochemical recurrence (BCR) after radical prostatectomy (RP) in a large multi-institutional cohort.METHODS: Survivin expression was evaluated by immunohistochemistry on a tissue microarray of RP cores from 3117 patients. Survivin expression was considered altered when at least 10% of the tumor cells stained positive. Association of altered Survivin expression with BCR was evaluated using Cox proportional hazards regression models.RESULTS: Survivin expression was altered in 1330 (42.6%) patients. Altered expression was associated with higher Gleason score on RP (p=0.001), extracapsular extension (p=0.019), seminal vesicle invasion (p<0.001) and lymph node metastases (p=0.009). Median follow up was 38 months (IQR 21-66). Patients with altered Survivin had a shorter BCR free survival than those with normal expression (5-year BCR free survival estimates: 74.7% vs 79.0%, p=0.008). Altered Survivin, however did not retain its prognostic value when adjusted for the effect of established clinico-pathological factors (p=0.73). Subgroup analyses also showed no independent prognostic value of Survivin.CONCLUSIONS: Survivin expression is commonly altered in RP patients. Altered Survivin expression is associated with clinicopathologic features of biologically and clinically aggressive PCa. Survivin expression was associated with BCR only in univariable analysis, limiting its value in daily clinical decision making. This article is protected by copyright. All rights reserved.
AB - OBJECTIVE: To assess the association of Survivin expression with clinicopathological features and biochemical recurrence (BCR) after radical prostatectomy (RP) in a large multi-institutional cohort.METHODS: Survivin expression was evaluated by immunohistochemistry on a tissue microarray of RP cores from 3117 patients. Survivin expression was considered altered when at least 10% of the tumor cells stained positive. Association of altered Survivin expression with BCR was evaluated using Cox proportional hazards regression models.RESULTS: Survivin expression was altered in 1330 (42.6%) patients. Altered expression was associated with higher Gleason score on RP (p=0.001), extracapsular extension (p=0.019), seminal vesicle invasion (p<0.001) and lymph node metastases (p=0.009). Median follow up was 38 months (IQR 21-66). Patients with altered Survivin had a shorter BCR free survival than those with normal expression (5-year BCR free survival estimates: 74.7% vs 79.0%, p=0.008). Altered Survivin, however did not retain its prognostic value when adjusted for the effect of established clinico-pathological factors (p=0.73). Subgroup analyses also showed no independent prognostic value of Survivin.CONCLUSIONS: Survivin expression is commonly altered in RP patients. Altered Survivin expression is associated with clinicopathologic features of biologically and clinically aggressive PCa. Survivin expression was associated with BCR only in univariable analysis, limiting its value in daily clinical decision making. This article is protected by copyright. All rights reserved.
U2 - 10.1111/bju.13472
DO - 10.1111/bju.13472
M3 - SCORING: Journal article
C2 - 26940243
VL - 119
SP - 234
EP - 238
JO - BJU INT
JF - BJU INT
SN - 1464-4096
IS - 2
ER -