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Role of Survivin expression in predicting biochemical recurrence after radical prostatectomy: a multi-institutional study

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Role of Survivin expression in predicting biochemical recurrence after radical prostatectomy: a multi-institutional study. / Mathieu, Romain; Lucca, Ilaria; Vartolomei, Mihai Dorin; MBeutcha, Aurélie; Klatte, Tobias; Seitz, Christian; Karakiewicz, Pierre I; Fajkovic, Harun; Sun, Maxine; Lotan, Yair; Montorsi, Francesco; Briganti, Alberto; Rouprêt, Morgan; Margulis, Vitaly; Rink, Michael; Rieken, Malte; Kenner, Lukas; Susani, Martin; Wolgang, Loidl; Shariat, Shahrokh F.

in: BJU INT, Jahrgang 119, Nr. 2, 02.2017, S. 234-238.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Mathieu, R, Lucca, I, Vartolomei, MD, MBeutcha, A, Klatte, T, Seitz, C, Karakiewicz, PI, Fajkovic, H, Sun, M, Lotan, Y, Montorsi, F, Briganti, A, Rouprêt, M, Margulis, V, Rink, M, Rieken, M, Kenner, L, Susani, M, Wolgang, L & Shariat, SF 2017, 'Role of Survivin expression in predicting biochemical recurrence after radical prostatectomy: a multi-institutional study', BJU INT, Jg. 119, Nr. 2, S. 234-238. https://doi.org/10.1111/bju.13472

APA

Mathieu, R., Lucca, I., Vartolomei, M. D., MBeutcha, A., Klatte, T., Seitz, C., Karakiewicz, P. I., Fajkovic, H., Sun, M., Lotan, Y., Montorsi, F., Briganti, A., Rouprêt, M., Margulis, V., Rink, M., Rieken, M., Kenner, L., Susani, M., Wolgang, L., & Shariat, S. F. (2017). Role of Survivin expression in predicting biochemical recurrence after radical prostatectomy: a multi-institutional study. BJU INT, 119(2), 234-238. https://doi.org/10.1111/bju.13472

Vancouver

Mathieu R, Lucca I, Vartolomei MD, MBeutcha A, Klatte T, Seitz C et al. Role of Survivin expression in predicting biochemical recurrence after radical prostatectomy: a multi-institutional study. BJU INT. 2017 Feb;119(2):234-238. https://doi.org/10.1111/bju.13472

Bibtex

@article{149da9fe821141159ee2b166c583433c,
title = "Role of Survivin expression in predicting biochemical recurrence after radical prostatectomy: a multi-institutional study",
abstract = "OBJECTIVE: To assess the association of Survivin expression with clinicopathological features and biochemical recurrence (BCR) after radical prostatectomy (RP) in a large multi-institutional cohort.METHODS: Survivin expression was evaluated by immunohistochemistry on a tissue microarray of RP cores from 3117 patients. Survivin expression was considered altered when at least 10% of the tumor cells stained positive. Association of altered Survivin expression with BCR was evaluated using Cox proportional hazards regression models.RESULTS: Survivin expression was altered in 1330 (42.6%) patients. Altered expression was associated with higher Gleason score on RP (p=0.001), extracapsular extension (p=0.019), seminal vesicle invasion (p<0.001) and lymph node metastases (p=0.009). Median follow up was 38 months (IQR 21-66). Patients with altered Survivin had a shorter BCR free survival than those with normal expression (5-year BCR free survival estimates: 74.7% vs 79.0%, p=0.008). Altered Survivin, however did not retain its prognostic value when adjusted for the effect of established clinico-pathological factors (p=0.73). Subgroup analyses also showed no independent prognostic value of Survivin.CONCLUSIONS: Survivin expression is commonly altered in RP patients. Altered Survivin expression is associated with clinicopathologic features of biologically and clinically aggressive PCa. Survivin expression was associated with BCR only in univariable analysis, limiting its value in daily clinical decision making. This article is protected by copyright. All rights reserved.",
author = "Romain Mathieu and Ilaria Lucca and Vartolomei, {Mihai Dorin} and Aur{\'e}lie MBeutcha and Tobias Klatte and Christian Seitz and Karakiewicz, {Pierre I} and Harun Fajkovic and Maxine Sun and Yair Lotan and Francesco Montorsi and Alberto Briganti and Morgan Roupr{\^e}t and Vitaly Margulis and Michael Rink and Malte Rieken and Lukas Kenner and Martin Susani and Loidl Wolgang and Shariat, {Shahrokh F}",
note = "This article is protected by copyright. All rights reserved.",
year = "2017",
month = feb,
doi = "10.1111/bju.13472",
language = "English",
volume = "119",
pages = "234--238",
journal = "BJU INT",
issn = "1464-4096",
publisher = "Wiley-Blackwell",
number = "2",

}

RIS

TY - JOUR

T1 - Role of Survivin expression in predicting biochemical recurrence after radical prostatectomy: a multi-institutional study

AU - Mathieu, Romain

AU - Lucca, Ilaria

AU - Vartolomei, Mihai Dorin

AU - MBeutcha, Aurélie

AU - Klatte, Tobias

AU - Seitz, Christian

AU - Karakiewicz, Pierre I

AU - Fajkovic, Harun

AU - Sun, Maxine

AU - Lotan, Yair

AU - Montorsi, Francesco

AU - Briganti, Alberto

AU - Rouprêt, Morgan

AU - Margulis, Vitaly

AU - Rink, Michael

AU - Rieken, Malte

AU - Kenner, Lukas

AU - Susani, Martin

AU - Wolgang, Loidl

AU - Shariat, Shahrokh F

N1 - This article is protected by copyright. All rights reserved.

PY - 2017/2

Y1 - 2017/2

N2 - OBJECTIVE: To assess the association of Survivin expression with clinicopathological features and biochemical recurrence (BCR) after radical prostatectomy (RP) in a large multi-institutional cohort.METHODS: Survivin expression was evaluated by immunohistochemistry on a tissue microarray of RP cores from 3117 patients. Survivin expression was considered altered when at least 10% of the tumor cells stained positive. Association of altered Survivin expression with BCR was evaluated using Cox proportional hazards regression models.RESULTS: Survivin expression was altered in 1330 (42.6%) patients. Altered expression was associated with higher Gleason score on RP (p=0.001), extracapsular extension (p=0.019), seminal vesicle invasion (p<0.001) and lymph node metastases (p=0.009). Median follow up was 38 months (IQR 21-66). Patients with altered Survivin had a shorter BCR free survival than those with normal expression (5-year BCR free survival estimates: 74.7% vs 79.0%, p=0.008). Altered Survivin, however did not retain its prognostic value when adjusted for the effect of established clinico-pathological factors (p=0.73). Subgroup analyses also showed no independent prognostic value of Survivin.CONCLUSIONS: Survivin expression is commonly altered in RP patients. Altered Survivin expression is associated with clinicopathologic features of biologically and clinically aggressive PCa. Survivin expression was associated with BCR only in univariable analysis, limiting its value in daily clinical decision making. This article is protected by copyright. All rights reserved.

AB - OBJECTIVE: To assess the association of Survivin expression with clinicopathological features and biochemical recurrence (BCR) after radical prostatectomy (RP) in a large multi-institutional cohort.METHODS: Survivin expression was evaluated by immunohistochemistry on a tissue microarray of RP cores from 3117 patients. Survivin expression was considered altered when at least 10% of the tumor cells stained positive. Association of altered Survivin expression with BCR was evaluated using Cox proportional hazards regression models.RESULTS: Survivin expression was altered in 1330 (42.6%) patients. Altered expression was associated with higher Gleason score on RP (p=0.001), extracapsular extension (p=0.019), seminal vesicle invasion (p<0.001) and lymph node metastases (p=0.009). Median follow up was 38 months (IQR 21-66). Patients with altered Survivin had a shorter BCR free survival than those with normal expression (5-year BCR free survival estimates: 74.7% vs 79.0%, p=0.008). Altered Survivin, however did not retain its prognostic value when adjusted for the effect of established clinico-pathological factors (p=0.73). Subgroup analyses also showed no independent prognostic value of Survivin.CONCLUSIONS: Survivin expression is commonly altered in RP patients. Altered Survivin expression is associated with clinicopathologic features of biologically and clinically aggressive PCa. Survivin expression was associated with BCR only in univariable analysis, limiting its value in daily clinical decision making. This article is protected by copyright. All rights reserved.

U2 - 10.1111/bju.13472

DO - 10.1111/bju.13472

M3 - SCORING: Journal article

C2 - 26940243

VL - 119

SP - 234

EP - 238

JO - BJU INT

JF - BJU INT

SN - 1464-4096

IS - 2

ER -