Role of panendoscopy in identifying and managing risk of head and neck squamous cell carcinoma in routine follow-up: a retrospective clinical evaluation
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Role of panendoscopy in identifying and managing risk of head and neck squamous cell carcinoma in routine follow-up: a retrospective clinical evaluation. / Münscher, Adrian; Sehner, Susanne; Taleh, Jegane; Tribius, Silke; Möckelmann, Nicolaus; Böttcher, Arne; Gulati, Amit; Dalchow, Carsten; Clauditz, Till; Knecht, Rainald.
In: EUR ARCH OTO-RHINO-L, Vol. 272, No. 7, 07.2015, p. 1769-75.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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T1 - Role of panendoscopy in identifying and managing risk of head and neck squamous cell carcinoma in routine follow-up: a retrospective clinical evaluation
AU - Münscher, Adrian
AU - Sehner, Susanne
AU - Taleh, Jegane
AU - Tribius, Silke
AU - Möckelmann, Nicolaus
AU - Böttcher, Arne
AU - Gulati, Amit
AU - Dalchow, Carsten
AU - Clauditz, Till
AU - Knecht, Rainald
PY - 2015/7
Y1 - 2015/7
N2 - We discuss the clinical effectiveness and predictive value of routine panendoscopy for surveillance and follow-up of head and neck squamous cell carcinoma (HNSCC). Retrospective comparative study. Department of Otolaryngology-Head and Neck Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. Two hundred and four HNSCC patients (follow-up between 2004 and 2007) were retrospectively evaluated. During follow-up, panendoscopy was performed routinely once a year. To avoid unnecessary procedures, we evaluated the value of radiological and clinical parameters in follow-up. On comparing normal-computerized tomography (CT) vs. abnormal CT results, a 13-fold higher frequency of recurrence (odds ratio 12.74; 95% CI 4.22, 38.48; p < 0.001) was found. Additionally, patient medical history, clinical investigation, and recurrence pattern were significant parameters when detecting a possible recurrence. Panendoscopy could have been avoided in 40% of patients with HNSCC (173/432). A follow-up schedule avoiding routine panendoscopy in HNSCC follow-up when the combination of diagnostic parameters is satisfactory does not influence the sensitivity or specificity of the test.
AB - We discuss the clinical effectiveness and predictive value of routine panendoscopy for surveillance and follow-up of head and neck squamous cell carcinoma (HNSCC). Retrospective comparative study. Department of Otolaryngology-Head and Neck Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. Two hundred and four HNSCC patients (follow-up between 2004 and 2007) were retrospectively evaluated. During follow-up, panendoscopy was performed routinely once a year. To avoid unnecessary procedures, we evaluated the value of radiological and clinical parameters in follow-up. On comparing normal-computerized tomography (CT) vs. abnormal CT results, a 13-fold higher frequency of recurrence (odds ratio 12.74; 95% CI 4.22, 38.48; p < 0.001) was found. Additionally, patient medical history, clinical investigation, and recurrence pattern were significant parameters when detecting a possible recurrence. Panendoscopy could have been avoided in 40% of patients with HNSCC (173/432). A follow-up schedule avoiding routine panendoscopy in HNSCC follow-up when the combination of diagnostic parameters is satisfactory does not influence the sensitivity or specificity of the test.
KW - Aged
KW - Carcinoma, Squamous Cell
KW - Disease Management
KW - Endoscopy
KW - Female
KW - Follow-Up Studies
KW - Germany
KW - Head and Neck Neoplasms
KW - Humans
KW - Incidence
KW - Male
KW - Middle Aged
KW - Neoplasm Recurrence, Local
KW - Neoplasm Staging
KW - Positron-Emission Tomography
KW - Predictive Value of Tests
KW - Prognosis
KW - Retrospective Studies
KW - Sensitivity and Specificity
KW - Tomography, X-Ray Computed
U2 - 10.1007/s00405-014-3125-0
DO - 10.1007/s00405-014-3125-0
M3 - SCORING: Journal article
C2 - 24906843
VL - 272
SP - 1769
EP - 1775
JO - EUR ARCH OTO-RHINO-L
JF - EUR ARCH OTO-RHINO-L
SN - 0937-4477
IS - 7
ER -