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Role of cell-cycle regulatory proteins in gynecological cancer.

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Role of cell-cycle regulatory proteins in gynecological cancer. / Milde-Langosch, Karin; Riethdorf, Sabine.

In: J CELL PHYSIOL, Vol. 196, No. 2, 2, 2003, p. 224-244.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Milde-Langosch, K & Riethdorf, S 2003, 'Role of cell-cycle regulatory proteins in gynecological cancer.', J CELL PHYSIOL, vol. 196, no. 2, 2, pp. 224-244. <http://www.ncbi.nlm.nih.gov/pubmed/12811815?dopt=Citation>

APA

Milde-Langosch, K., & Riethdorf, S. (2003). Role of cell-cycle regulatory proteins in gynecological cancer. J CELL PHYSIOL, 196(2), 224-244. [2]. http://www.ncbi.nlm.nih.gov/pubmed/12811815?dopt=Citation

Vancouver

Milde-Langosch K, Riethdorf S. Role of cell-cycle regulatory proteins in gynecological cancer. J CELL PHYSIOL. 2003;196(2):224-244. 2.

Bibtex

@article{60aaf80865ac4bbc8c2f2df038044c2d,
title = "Role of cell-cycle regulatory proteins in gynecological cancer.",
abstract = "Human malignant tumors are characterized by abnormal proliferation resulting from alterations in cell-cycle regulatory mechanisms. This review summarizes the current knowledge about these aberrations in malignant tumors of the ovary, endometrium, cervix uteri, and vulva. The data indicate that analysis of single cell cycle stimulating or inhibiting proteins partly produces unexpected, apparently paradoxical results, and cell-cycle regulatory pathways should be regarded as a whole in order to identify the molecular mechanisms leading to abnormal tumor cell proliferation. For the papillomavirus (HPV)- associated cervical and vulvar carcinomas, the manifold effects of the viral oncogenes E6 and E7 on cell-cycle control are described.",
keywords = "Humans, Female, Cell Cycle Proteins/*metabolism, Endometrial Neoplasms/physiopathology, Genital Neoplasms, Female/pathology/*physiopathology, Ovarian Neoplasms/physiopathology, Uterine Cervical Neoplasms/physiopathology, Vulvar Neoplasms/physiopathology, Humans, Female, Cell Cycle Proteins/*metabolism, Endometrial Neoplasms/physiopathology, Genital Neoplasms, Female/pathology/*physiopathology, Ovarian Neoplasms/physiopathology, Uterine Cervical Neoplasms/physiopathology, Vulvar Neoplasms/physiopathology",
author = "Karin Milde-Langosch and Sabine Riethdorf",
year = "2003",
language = "English",
volume = "196",
pages = "224--244",
journal = "J CELL PHYSIOL",
issn = "0021-9541",
publisher = "Wiley-Liss Inc.",
number = "2",

}

RIS

TY - JOUR

T1 - Role of cell-cycle regulatory proteins in gynecological cancer.

AU - Milde-Langosch, Karin

AU - Riethdorf, Sabine

PY - 2003

Y1 - 2003

N2 - Human malignant tumors are characterized by abnormal proliferation resulting from alterations in cell-cycle regulatory mechanisms. This review summarizes the current knowledge about these aberrations in malignant tumors of the ovary, endometrium, cervix uteri, and vulva. The data indicate that analysis of single cell cycle stimulating or inhibiting proteins partly produces unexpected, apparently paradoxical results, and cell-cycle regulatory pathways should be regarded as a whole in order to identify the molecular mechanisms leading to abnormal tumor cell proliferation. For the papillomavirus (HPV)- associated cervical and vulvar carcinomas, the manifold effects of the viral oncogenes E6 and E7 on cell-cycle control are described.

AB - Human malignant tumors are characterized by abnormal proliferation resulting from alterations in cell-cycle regulatory mechanisms. This review summarizes the current knowledge about these aberrations in malignant tumors of the ovary, endometrium, cervix uteri, and vulva. The data indicate that analysis of single cell cycle stimulating or inhibiting proteins partly produces unexpected, apparently paradoxical results, and cell-cycle regulatory pathways should be regarded as a whole in order to identify the molecular mechanisms leading to abnormal tumor cell proliferation. For the papillomavirus (HPV)- associated cervical and vulvar carcinomas, the manifold effects of the viral oncogenes E6 and E7 on cell-cycle control are described.

KW - Humans

KW - Female

KW - Cell Cycle Proteins/metabolism

KW - Endometrial Neoplasms/physiopathology

KW - Genital Neoplasms, Female/pathology/physiopathology

KW - Ovarian Neoplasms/physiopathology

KW - Uterine Cervical Neoplasms/physiopathology

KW - Vulvar Neoplasms/physiopathology

KW - Humans

KW - Female

KW - Cell Cycle Proteins/metabolism

KW - Endometrial Neoplasms/physiopathology

KW - Genital Neoplasms, Female/pathology/physiopathology

KW - Ovarian Neoplasms/physiopathology

KW - Uterine Cervical Neoplasms/physiopathology

KW - Vulvar Neoplasms/physiopathology

M3 - SCORING: Journal article

VL - 196

SP - 224

EP - 244

JO - J CELL PHYSIOL

JF - J CELL PHYSIOL

SN - 0021-9541

IS - 2

M1 - 2

ER -