Role of cell-cycle regulatory proteins in gynecological cancer.
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Role of cell-cycle regulatory proteins in gynecological cancer. / Milde-Langosch, Karin; Riethdorf, Sabine.
in: J CELL PHYSIOL, Jahrgang 196, Nr. 2, 2, 2003, S. 224-244.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Role of cell-cycle regulatory proteins in gynecological cancer.
AU - Milde-Langosch, Karin
AU - Riethdorf, Sabine
PY - 2003
Y1 - 2003
N2 - Human malignant tumors are characterized by abnormal proliferation resulting from alterations in cell-cycle regulatory mechanisms. This review summarizes the current knowledge about these aberrations in malignant tumors of the ovary, endometrium, cervix uteri, and vulva. The data indicate that analysis of single cell cycle stimulating or inhibiting proteins partly produces unexpected, apparently paradoxical results, and cell-cycle regulatory pathways should be regarded as a whole in order to identify the molecular mechanisms leading to abnormal tumor cell proliferation. For the papillomavirus (HPV)- associated cervical and vulvar carcinomas, the manifold effects of the viral oncogenes E6 and E7 on cell-cycle control are described.
AB - Human malignant tumors are characterized by abnormal proliferation resulting from alterations in cell-cycle regulatory mechanisms. This review summarizes the current knowledge about these aberrations in malignant tumors of the ovary, endometrium, cervix uteri, and vulva. The data indicate that analysis of single cell cycle stimulating or inhibiting proteins partly produces unexpected, apparently paradoxical results, and cell-cycle regulatory pathways should be regarded as a whole in order to identify the molecular mechanisms leading to abnormal tumor cell proliferation. For the papillomavirus (HPV)- associated cervical and vulvar carcinomas, the manifold effects of the viral oncogenes E6 and E7 on cell-cycle control are described.
KW - Humans
KW - Female
KW - Cell Cycle Proteins/metabolism
KW - Endometrial Neoplasms/physiopathology
KW - Genital Neoplasms, Female/pathology/physiopathology
KW - Ovarian Neoplasms/physiopathology
KW - Uterine Cervical Neoplasms/physiopathology
KW - Vulvar Neoplasms/physiopathology
KW - Humans
KW - Female
KW - Cell Cycle Proteins/metabolism
KW - Endometrial Neoplasms/physiopathology
KW - Genital Neoplasms, Female/pathology/physiopathology
KW - Ovarian Neoplasms/physiopathology
KW - Uterine Cervical Neoplasms/physiopathology
KW - Vulvar Neoplasms/physiopathology
M3 - SCORING: Journal article
VL - 196
SP - 224
EP - 244
JO - J CELL PHYSIOL
JF - J CELL PHYSIOL
SN - 0021-9541
IS - 2
M1 - 2
ER -