Research ExplorerPublicationsRisk factors for a severe disease course in children with SA...

Risk factors for a severe disease course in children with SARS-COV-2 infection following hematopoietic cell transplantation in the pre-Omicron period

Standard

Risk factors for a severe disease course in children with SARS-COV-2 infection following hematopoietic cell transplantation in the pre-Omicron period : A prospective multinational Infectious Disease Working Party from the European Society for Blood and Marrow Transplantation group (EBMT) and the Spanish Group of Hematopoietic Stem Cell Transplantation (GETH) study. / Averbuch, Dina; de la Camara, Rafael; Tridello, Gloria; Knelange, Nina Simone; Bykova, Tatiana A; Ifversen, Marianne; Dobsinska, Veronika; Ayas, Mouhab; Hamidieh, Amir Ali; Pichler, Herbert; Perez-Martinez, Antonio; Cesaro, Simone; Sundin, Mikael; Badell, Isabel; Bader, Peter; Johansson, Jan-Erik; Mirci-Danicar, Oana; Sedlacek, Petr; Paillard, Catherine; Gibson, Brenda; Lawson, Sarah; Kroeger, Nicolaus; Corbacioglu, Selim; Mikulska, Malgorzata; Piñana, Jose Luis; Styczynski, Jan; Ljungman, Per.

In: BONE MARROW TRANSPL, Vol. 58, No. 5, 05.2023, p. 558-566.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Averbuch, D, de la Camara, R, Tridello, G, Knelange, NS, Bykova, TA, Ifversen, M, Dobsinska, V, Ayas, M, Hamidieh, AA, Pichler, H, Perez-Martinez, A, Cesaro, S, Sundin, M, Badell, I, Bader, P, Johansson, J-E, Mirci-Danicar, O, Sedlacek, P, Paillard, C, Gibson, B, Lawson, S, Kroeger, N, Corbacioglu, S, Mikulska, M, Piñana, JL, Styczynski, J & Ljungman, P 2023, 'Risk factors for a severe disease course in children with SARS-COV-2 infection following hematopoietic cell transplantation in the pre-Omicron period: A prospective multinational Infectious Disease Working Party from the European Society for Blood and Marrow Transplantation group (EBMT) and the Spanish Group of Hematopoietic Stem Cell Transplantation (GETH) study', BONE MARROW TRANSPL, vol. 58, no. 5, pp. 558-566. https://doi.org/10.1038/s41409-023-01941-5

APA

Averbuch, D., de la Camara, R., Tridello, G., Knelange, N. S., Bykova, T. A., Ifversen, M., Dobsinska, V., Ayas, M., Hamidieh, A. A., Pichler, H., Perez-Martinez, A., Cesaro, S., Sundin, M., Badell, I., Bader, P., Johansson, J-E., Mirci-Danicar, O., Sedlacek, P., Paillard, C., ... Ljungman, P. (2023). Risk factors for a severe disease course in children with SARS-COV-2 infection following hematopoietic cell transplantation in the pre-Omicron period: A prospective multinational Infectious Disease Working Party from the European Society for Blood and Marrow Transplantation group (EBMT) and the Spanish Group of Hematopoietic Stem Cell Transplantation (GETH) study. BONE MARROW TRANSPL, 58(5), 558-566. https://doi.org/10.1038/s41409-023-01941-5

Vancouver

Averbuch D, de la Camara R, Tridello G, Knelange NS, Bykova TA, Ifversen M et al. Risk factors for a severe disease course in children with SARS-COV-2 infection following hematopoietic cell transplantation in the pre-Omicron period: A prospective multinational Infectious Disease Working Party from the European Society for Blood and Marrow Transplantation group (EBMT) and the Spanish Group of Hematopoietic Stem Cell Transplantation (GETH) study. BONE MARROW TRANSPL. 2023 May;58(5):558-566. https://doi.org/10.1038/s41409-023-01941-5

Bibtex

@article{c2bc707f43b440558f4873c4cd6d040d,
title = "Risk factors for a severe disease course in children with SARS-COV-2 infection following hematopoietic cell transplantation in the pre-Omicron period: A prospective multinational Infectious Disease Working Party from the European Society for Blood and Marrow Transplantation group (EBMT) and the Spanish Group of Hematopoietic Stem Cell Transplantation (GETH) study",
abstract = "Risk factors for severe SARS-Cov-2 infection course are poorly described in children following hematopoietic cell transplantation (HCT). In this international study, we analyzed factors associated with a severe course (intensive care unit (ICU) admission and/or mortality) in post-HCT children. Eighty-nine children (58% male; median age 9 years (min-max 1-18)) who received an allogeneic (85; 96%) or an autologous (4; 4%) HCT were reported from 28 centers (18 countries). Median time from HCT to SARS-Cov-2 infection was 7 months (min-max 0-181). The most common clinical manifestations included fever (37; 42%) and cough (26; 29%); 37 (42%) were asymptomatic. Nine (10%) children following allo-HCT required ICU care. Seven children (8%) following allo-HCT, died at a median of 22 days after SARS-Cov-2 diagnosis. In a univariate analysis, the probability of a severe disease course was higher in allo-HCT children with chronic GVHD, non-malignant disease, immune suppressive treatment (specifically, mycophenolate), moderate immunodeficiency score, low Lansky score, fever, cough, coinfection, pulmonary radiological findings, and high C-reactive protein. In conclusion, SARS-Cov-2 infection in children following HCT was frequently asymptomatic. Despite this, 10% needed ICU admission and 8% died in our cohort. Certain HCT, underlying disease, and SARS-Cov-2 related factors were associated with a severe disease course.",
keywords = "Humans, Male, Child, Female, Transplantation, Homologous, Prospective Studies, Bone Marrow, COVID-19 Testing, Cough/etiology, COVID-19/etiology, SARS-CoV-2, Hematopoietic Stem Cell Transplantation/adverse effects, Risk Factors, Disease Progression, Communicable Diseases/etiology",
author = "Dina Averbuch and {de la Camara}, Rafael and Gloria Tridello and Knelange, {Nina Simone} and Bykova, {Tatiana A} and Marianne Ifversen and Veronika Dobsinska and Mouhab Ayas and Hamidieh, {Amir Ali} and Herbert Pichler and Antonio Perez-Martinez and Simone Cesaro and Mikael Sundin and Isabel Badell and Peter Bader and Jan-Erik Johansson and Oana Mirci-Danicar and Petr Sedlacek and Catherine Paillard and Brenda Gibson and Sarah Lawson and Nicolaus Kroeger and Selim Corbacioglu and Malgorzata Mikulska and Pi{\~n}ana, {Jose Luis} and Jan Styczynski and Per Ljungman",
note = "{\textcopyright} 2023. The Author(s), under exclusive licence to Springer Nature Limited.",
year = "2023",
month = may,
doi = "10.1038/s41409-023-01941-5",
language = "English",
volume = "58",
pages = "558--566",
journal = "BONE MARROW TRANSPL",
issn = "0268-3369",
publisher = "NATURE PUBLISHING GROUP",
number = "5",

}

RIS

TY - JOUR

T1 - Risk factors for a severe disease course in children with SARS-COV-2 infection following hematopoietic cell transplantation in the pre-Omicron period

T2 - A prospective multinational Infectious Disease Working Party from the European Society for Blood and Marrow Transplantation group (EBMT) and the Spanish Group of Hematopoietic Stem Cell Transplantation (GETH) study

AU - Averbuch, Dina

AU - de la Camara, Rafael

AU - Tridello, Gloria

AU - Knelange, Nina Simone

AU - Bykova, Tatiana A

AU - Ifversen, Marianne

AU - Dobsinska, Veronika

AU - Ayas, Mouhab

AU - Hamidieh, Amir Ali

AU - Pichler, Herbert

AU - Perez-Martinez, Antonio

AU - Cesaro, Simone

AU - Sundin, Mikael

AU - Badell, Isabel

AU - Bader, Peter

AU - Johansson, Jan-Erik

AU - Mirci-Danicar, Oana

AU - Sedlacek, Petr

AU - Paillard, Catherine

AU - Gibson, Brenda

AU - Lawson, Sarah

AU - Kroeger, Nicolaus

AU - Corbacioglu, Selim

AU - Mikulska, Malgorzata

AU - Piñana, Jose Luis

AU - Styczynski, Jan

AU - Ljungman, Per

N1 - © 2023. The Author(s), under exclusive licence to Springer Nature Limited.

PY - 2023/5

Y1 - 2023/5

N2 - Risk factors for severe SARS-Cov-2 infection course are poorly described in children following hematopoietic cell transplantation (HCT). In this international study, we analyzed factors associated with a severe course (intensive care unit (ICU) admission and/or mortality) in post-HCT children. Eighty-nine children (58% male; median age 9 years (min-max 1-18)) who received an allogeneic (85; 96%) or an autologous (4; 4%) HCT were reported from 28 centers (18 countries). Median time from HCT to SARS-Cov-2 infection was 7 months (min-max 0-181). The most common clinical manifestations included fever (37; 42%) and cough (26; 29%); 37 (42%) were asymptomatic. Nine (10%) children following allo-HCT required ICU care. Seven children (8%) following allo-HCT, died at a median of 22 days after SARS-Cov-2 diagnosis. In a univariate analysis, the probability of a severe disease course was higher in allo-HCT children with chronic GVHD, non-malignant disease, immune suppressive treatment (specifically, mycophenolate), moderate immunodeficiency score, low Lansky score, fever, cough, coinfection, pulmonary radiological findings, and high C-reactive protein. In conclusion, SARS-Cov-2 infection in children following HCT was frequently asymptomatic. Despite this, 10% needed ICU admission and 8% died in our cohort. Certain HCT, underlying disease, and SARS-Cov-2 related factors were associated with a severe disease course.

AB - Risk factors for severe SARS-Cov-2 infection course are poorly described in children following hematopoietic cell transplantation (HCT). In this international study, we analyzed factors associated with a severe course (intensive care unit (ICU) admission and/or mortality) in post-HCT children. Eighty-nine children (58% male; median age 9 years (min-max 1-18)) who received an allogeneic (85; 96%) or an autologous (4; 4%) HCT were reported from 28 centers (18 countries). Median time from HCT to SARS-Cov-2 infection was 7 months (min-max 0-181). The most common clinical manifestations included fever (37; 42%) and cough (26; 29%); 37 (42%) were asymptomatic. Nine (10%) children following allo-HCT required ICU care. Seven children (8%) following allo-HCT, died at a median of 22 days after SARS-Cov-2 diagnosis. In a univariate analysis, the probability of a severe disease course was higher in allo-HCT children with chronic GVHD, non-malignant disease, immune suppressive treatment (specifically, mycophenolate), moderate immunodeficiency score, low Lansky score, fever, cough, coinfection, pulmonary radiological findings, and high C-reactive protein. In conclusion, SARS-Cov-2 infection in children following HCT was frequently asymptomatic. Despite this, 10% needed ICU admission and 8% died in our cohort. Certain HCT, underlying disease, and SARS-Cov-2 related factors were associated with a severe disease course.

KW - Humans

KW - Male

KW - Child

KW - Female

KW - Transplantation, Homologous

KW - Prospective Studies

KW - Bone Marrow

KW - COVID-19 Testing

KW - Cough/etiology

KW - COVID-19/etiology

KW - SARS-CoV-2

KW - Hematopoietic Stem Cell Transplantation/adverse effects

KW - Risk Factors

KW - Disease Progression

KW - Communicable Diseases/etiology

U2 - 10.1038/s41409-023-01941-5

DO - 10.1038/s41409-023-01941-5

M3 - SCORING: Journal article

C2 - 36849806

VL - 58

SP - 558

EP - 566

JO - BONE MARROW TRANSPL

JF - BONE MARROW TRANSPL

SN - 0268-3369

IS - 5

ER -