Risk factors for a severe disease course in children with SARS-COV-2 infection following hematopoietic cell transplantation in the pre-Omicron period
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Risk factors for a severe disease course in children with SARS-COV-2 infection following hematopoietic cell transplantation in the pre-Omicron period : A prospective multinational Infectious Disease Working Party from the European Society for Blood and Marrow Transplantation group (EBMT) and the Spanish Group of Hematopoietic Stem Cell Transplantation (GETH) study. / Averbuch, Dina; de la Camara, Rafael; Tridello, Gloria; Knelange, Nina Simone; Bykova, Tatiana A; Ifversen, Marianne; Dobsinska, Veronika; Ayas, Mouhab; Hamidieh, Amir Ali; Pichler, Herbert; Perez-Martinez, Antonio; Cesaro, Simone; Sundin, Mikael; Badell, Isabel; Bader, Peter; Johansson, Jan-Erik; Mirci-Danicar, Oana; Sedlacek, Petr; Paillard, Catherine; Gibson, Brenda; Lawson, Sarah; Kroeger, Nicolaus; Corbacioglu, Selim; Mikulska, Malgorzata; Piñana, Jose Luis; Styczynski, Jan; Ljungman, Per.
in: BONE MARROW TRANSPL, Jahrgang 58, Nr. 5, 05.2023, S. 558-566.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Risk factors for a severe disease course in children with SARS-COV-2 infection following hematopoietic cell transplantation in the pre-Omicron period
T2 - A prospective multinational Infectious Disease Working Party from the European Society for Blood and Marrow Transplantation group (EBMT) and the Spanish Group of Hematopoietic Stem Cell Transplantation (GETH) study
AU - Averbuch, Dina
AU - de la Camara, Rafael
AU - Tridello, Gloria
AU - Knelange, Nina Simone
AU - Bykova, Tatiana A
AU - Ifversen, Marianne
AU - Dobsinska, Veronika
AU - Ayas, Mouhab
AU - Hamidieh, Amir Ali
AU - Pichler, Herbert
AU - Perez-Martinez, Antonio
AU - Cesaro, Simone
AU - Sundin, Mikael
AU - Badell, Isabel
AU - Bader, Peter
AU - Johansson, Jan-Erik
AU - Mirci-Danicar, Oana
AU - Sedlacek, Petr
AU - Paillard, Catherine
AU - Gibson, Brenda
AU - Lawson, Sarah
AU - Kroeger, Nicolaus
AU - Corbacioglu, Selim
AU - Mikulska, Malgorzata
AU - Piñana, Jose Luis
AU - Styczynski, Jan
AU - Ljungman, Per
N1 - © 2023. The Author(s), under exclusive licence to Springer Nature Limited.
PY - 2023/5
Y1 - 2023/5
N2 - Risk factors for severe SARS-Cov-2 infection course are poorly described in children following hematopoietic cell transplantation (HCT). In this international study, we analyzed factors associated with a severe course (intensive care unit (ICU) admission and/or mortality) in post-HCT children. Eighty-nine children (58% male; median age 9 years (min-max 1-18)) who received an allogeneic (85; 96%) or an autologous (4; 4%) HCT were reported from 28 centers (18 countries). Median time from HCT to SARS-Cov-2 infection was 7 months (min-max 0-181). The most common clinical manifestations included fever (37; 42%) and cough (26; 29%); 37 (42%) were asymptomatic. Nine (10%) children following allo-HCT required ICU care. Seven children (8%) following allo-HCT, died at a median of 22 days after SARS-Cov-2 diagnosis. In a univariate analysis, the probability of a severe disease course was higher in allo-HCT children with chronic GVHD, non-malignant disease, immune suppressive treatment (specifically, mycophenolate), moderate immunodeficiency score, low Lansky score, fever, cough, coinfection, pulmonary radiological findings, and high C-reactive protein. In conclusion, SARS-Cov-2 infection in children following HCT was frequently asymptomatic. Despite this, 10% needed ICU admission and 8% died in our cohort. Certain HCT, underlying disease, and SARS-Cov-2 related factors were associated with a severe disease course.
AB - Risk factors for severe SARS-Cov-2 infection course are poorly described in children following hematopoietic cell transplantation (HCT). In this international study, we analyzed factors associated with a severe course (intensive care unit (ICU) admission and/or mortality) in post-HCT children. Eighty-nine children (58% male; median age 9 years (min-max 1-18)) who received an allogeneic (85; 96%) or an autologous (4; 4%) HCT were reported from 28 centers (18 countries). Median time from HCT to SARS-Cov-2 infection was 7 months (min-max 0-181). The most common clinical manifestations included fever (37; 42%) and cough (26; 29%); 37 (42%) were asymptomatic. Nine (10%) children following allo-HCT required ICU care. Seven children (8%) following allo-HCT, died at a median of 22 days after SARS-Cov-2 diagnosis. In a univariate analysis, the probability of a severe disease course was higher in allo-HCT children with chronic GVHD, non-malignant disease, immune suppressive treatment (specifically, mycophenolate), moderate immunodeficiency score, low Lansky score, fever, cough, coinfection, pulmonary radiological findings, and high C-reactive protein. In conclusion, SARS-Cov-2 infection in children following HCT was frequently asymptomatic. Despite this, 10% needed ICU admission and 8% died in our cohort. Certain HCT, underlying disease, and SARS-Cov-2 related factors were associated with a severe disease course.
KW - Humans
KW - Male
KW - Child
KW - Female
KW - Transplantation, Homologous
KW - Prospective Studies
KW - Bone Marrow
KW - COVID-19 Testing
KW - Cough/etiology
KW - COVID-19/etiology
KW - SARS-CoV-2
KW - Hematopoietic Stem Cell Transplantation/adverse effects
KW - Risk Factors
KW - Disease Progression
KW - Communicable Diseases/etiology
U2 - 10.1038/s41409-023-01941-5
DO - 10.1038/s41409-023-01941-5
M3 - SCORING: Journal article
C2 - 36849806
VL - 58
SP - 558
EP - 566
JO - BONE MARROW TRANSPL
JF - BONE MARROW TRANSPL
SN - 0268-3369
IS - 5
ER -