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Resting-state brain and spinal cord networks in humans are functionally integrated

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Resting-state brain and spinal cord networks in humans are functionally integrated. / Vahdat, Shahabeddin; Khatibi, Ali; Lungu, Ovidiu; Finsterbusch, Jürgen; Büchel, Christian; Cohen-Adad, Julien; Marchand-Pauvert, Veronique; Doyon, Julien.

In: PLOS BIOL, Vol. 18, No. 7, e3000789, 07.2020.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Vahdat, S, Khatibi, A, Lungu, O, Finsterbusch, J, Büchel, C, Cohen-Adad, J, Marchand-Pauvert, V & Doyon, J 2020, 'Resting-state brain and spinal cord networks in humans are functionally integrated', PLOS BIOL, vol. 18, no. 7, e3000789. https://doi.org/10.1371/journal.pbio.3000789

APA

Vahdat, S., Khatibi, A., Lungu, O., Finsterbusch, J., Büchel, C., Cohen-Adad, J., Marchand-Pauvert, V., & Doyon, J. (2020). Resting-state brain and spinal cord networks in humans are functionally integrated. PLOS BIOL, 18(7), [e3000789]. https://doi.org/10.1371/journal.pbio.3000789

Vancouver

Vahdat S, Khatibi A, Lungu O, Finsterbusch J, Büchel C, Cohen-Adad J et al. Resting-state brain and spinal cord networks in humans are functionally integrated. PLOS BIOL. 2020 Jul;18(7). e3000789. https://doi.org/10.1371/journal.pbio.3000789

Bibtex

@article{1bb4fc081c29496c8e13b747d598cf46,
title = "Resting-state brain and spinal cord networks in humans are functionally integrated",
abstract = "In the absence of any task, both the brain and spinal cord exhibit spontaneous intrinsic activity organised in a set of functionally relevant neural networks. However, whether such resting-state networks (RSNs) are interconnected across the brain and spinal cord is unclear. Here, we used a unique scanning protocol to acquire functional images of both brain and cervical spinal cord (CSC) simultaneously and examined their spatiotemporal correspondence in humans. We show that the brain and spinal cord activities are strongly correlated during rest periods, and specific spinal cord regions are functionally linked to consistently reported brain sensorimotor RSNs. The functional organisation of these networks follows well-established anatomical principles, including the contralateral correspondence between the spinal hemicords and brain hemispheres as well as sensory versus motor segregation of neural pathways along the brain-spinal cord axis. Thus, our findings reveal a unified functional organisation of sensorimotor networks in the entire central nervous system (CNS) at rest.",
keywords = "Adult, Brain/physiology, Brain Mapping, Cerebral Cortex/physiology, Female, Humans, Male, Nerve Net/physiology, Rest/physiology, Spinal Cord/physiology",
author = "Shahabeddin Vahdat and Ali Khatibi and Ovidiu Lungu and J{\"u}rgen Finsterbusch and Christian B{\"u}chel and Julien Cohen-Adad and Veronique Marchand-Pauvert and Julien Doyon",
year = "2020",
month = jul,
doi = "10.1371/journal.pbio.3000789",
language = "English",
volume = "18",
journal = "PLOS BIOL",
issn = "1544-9173",
publisher = "Public Library of Science",
number = "7",

}

RIS

TY - JOUR

T1 - Resting-state brain and spinal cord networks in humans are functionally integrated

AU - Vahdat, Shahabeddin

AU - Khatibi, Ali

AU - Lungu, Ovidiu

AU - Finsterbusch, Jürgen

AU - Büchel, Christian

AU - Cohen-Adad, Julien

AU - Marchand-Pauvert, Veronique

AU - Doyon, Julien

PY - 2020/7

Y1 - 2020/7

N2 - In the absence of any task, both the brain and spinal cord exhibit spontaneous intrinsic activity organised in a set of functionally relevant neural networks. However, whether such resting-state networks (RSNs) are interconnected across the brain and spinal cord is unclear. Here, we used a unique scanning protocol to acquire functional images of both brain and cervical spinal cord (CSC) simultaneously and examined their spatiotemporal correspondence in humans. We show that the brain and spinal cord activities are strongly correlated during rest periods, and specific spinal cord regions are functionally linked to consistently reported brain sensorimotor RSNs. The functional organisation of these networks follows well-established anatomical principles, including the contralateral correspondence between the spinal hemicords and brain hemispheres as well as sensory versus motor segregation of neural pathways along the brain-spinal cord axis. Thus, our findings reveal a unified functional organisation of sensorimotor networks in the entire central nervous system (CNS) at rest.

AB - In the absence of any task, both the brain and spinal cord exhibit spontaneous intrinsic activity organised in a set of functionally relevant neural networks. However, whether such resting-state networks (RSNs) are interconnected across the brain and spinal cord is unclear. Here, we used a unique scanning protocol to acquire functional images of both brain and cervical spinal cord (CSC) simultaneously and examined their spatiotemporal correspondence in humans. We show that the brain and spinal cord activities are strongly correlated during rest periods, and specific spinal cord regions are functionally linked to consistently reported brain sensorimotor RSNs. The functional organisation of these networks follows well-established anatomical principles, including the contralateral correspondence between the spinal hemicords and brain hemispheres as well as sensory versus motor segregation of neural pathways along the brain-spinal cord axis. Thus, our findings reveal a unified functional organisation of sensorimotor networks in the entire central nervous system (CNS) at rest.

KW - Adult

KW - Brain/physiology

KW - Brain Mapping

KW - Cerebral Cortex/physiology

KW - Female

KW - Humans

KW - Male

KW - Nerve Net/physiology

KW - Rest/physiology

KW - Spinal Cord/physiology

U2 - 10.1371/journal.pbio.3000789

DO - 10.1371/journal.pbio.3000789

M3 - SCORING: Journal article

C2 - 32614823

VL - 18

JO - PLOS BIOL

JF - PLOS BIOL

SN - 1544-9173

IS - 7

M1 - e3000789

ER -