Resting-state brain and spinal cord networks in humans are functionally integrated
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Resting-state brain and spinal cord networks in humans are functionally integrated. / Vahdat, Shahabeddin; Khatibi, Ali; Lungu, Ovidiu; Finsterbusch, Jürgen; Büchel, Christian; Cohen-Adad, Julien; Marchand-Pauvert, Veronique; Doyon, Julien.
in: PLOS BIOL, Jahrgang 18, Nr. 7, e3000789, 07.2020.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Resting-state brain and spinal cord networks in humans are functionally integrated
AU - Vahdat, Shahabeddin
AU - Khatibi, Ali
AU - Lungu, Ovidiu
AU - Finsterbusch, Jürgen
AU - Büchel, Christian
AU - Cohen-Adad, Julien
AU - Marchand-Pauvert, Veronique
AU - Doyon, Julien
PY - 2020/7
Y1 - 2020/7
N2 - In the absence of any task, both the brain and spinal cord exhibit spontaneous intrinsic activity organised in a set of functionally relevant neural networks. However, whether such resting-state networks (RSNs) are interconnected across the brain and spinal cord is unclear. Here, we used a unique scanning protocol to acquire functional images of both brain and cervical spinal cord (CSC) simultaneously and examined their spatiotemporal correspondence in humans. We show that the brain and spinal cord activities are strongly correlated during rest periods, and specific spinal cord regions are functionally linked to consistently reported brain sensorimotor RSNs. The functional organisation of these networks follows well-established anatomical principles, including the contralateral correspondence between the spinal hemicords and brain hemispheres as well as sensory versus motor segregation of neural pathways along the brain-spinal cord axis. Thus, our findings reveal a unified functional organisation of sensorimotor networks in the entire central nervous system (CNS) at rest.
AB - In the absence of any task, both the brain and spinal cord exhibit spontaneous intrinsic activity organised in a set of functionally relevant neural networks. However, whether such resting-state networks (RSNs) are interconnected across the brain and spinal cord is unclear. Here, we used a unique scanning protocol to acquire functional images of both brain and cervical spinal cord (CSC) simultaneously and examined their spatiotemporal correspondence in humans. We show that the brain and spinal cord activities are strongly correlated during rest periods, and specific spinal cord regions are functionally linked to consistently reported brain sensorimotor RSNs. The functional organisation of these networks follows well-established anatomical principles, including the contralateral correspondence between the spinal hemicords and brain hemispheres as well as sensory versus motor segregation of neural pathways along the brain-spinal cord axis. Thus, our findings reveal a unified functional organisation of sensorimotor networks in the entire central nervous system (CNS) at rest.
KW - Adult
KW - Brain/physiology
KW - Brain Mapping
KW - Cerebral Cortex/physiology
KW - Female
KW - Humans
KW - Male
KW - Nerve Net/physiology
KW - Rest/physiology
KW - Spinal Cord/physiology
U2 - 10.1371/journal.pbio.3000789
DO - 10.1371/journal.pbio.3000789
M3 - SCORING: Journal article
C2 - 32614823
VL - 18
JO - PLOS BIOL
JF - PLOS BIOL
SN - 1544-9173
IS - 7
M1 - e3000789
ER -