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Repair of oronasal fistulas with human amniotic membrane in minipigs

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Repair of oronasal fistulas with human amniotic membrane in minipigs. / Kesting, Marco Rainer; Loeffelbein, Denys John; Classen, Mariella; Slotta-Huspenina, Julia; Hasler, Rafael Johannes; Jacobsen, Frank; Kreutzer, Kilian; Al-Benna, Sammy; Wolff, Klaus-Dietrich; Steinstraesser, Lars.

In: BRIT J ORAL MAX SURG, Vol. 48, No. 2, 03.2010, p. 131–135.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Kesting, MR, Loeffelbein, DJ, Classen, M, Slotta-Huspenina, J, Hasler, RJ, Jacobsen, F, Kreutzer, K, Al-Benna, S, Wolff, K-D & Steinstraesser, L 2010, 'Repair of oronasal fistulas with human amniotic membrane in minipigs', BRIT J ORAL MAX SURG, vol. 48, no. 2, pp. 131–135. https://doi.org/10.1016/j.bjoms.2009.04.025

APA

Kesting, M. R., Loeffelbein, D. J., Classen, M., Slotta-Huspenina, J., Hasler, R. J., Jacobsen, F., Kreutzer, K., Al-Benna, S., Wolff, K-D., & Steinstraesser, L. (2010). Repair of oronasal fistulas with human amniotic membrane in minipigs. BRIT J ORAL MAX SURG, 48(2), 131–135. https://doi.org/10.1016/j.bjoms.2009.04.025

Vancouver

Kesting MR, Loeffelbein DJ, Classen M, Slotta-Huspenina J, Hasler RJ, Jacobsen F et al. Repair of oronasal fistulas with human amniotic membrane in minipigs. BRIT J ORAL MAX SURG. 2010 Mar;48(2):131–135. https://doi.org/10.1016/j.bjoms.2009.04.025

Bibtex

@article{f25693d7e53c4b4da1b49e425099aaf5,
title = "Repair of oronasal fistulas with human amniotic membrane in minipigs",
abstract = "We evaluated the use of multilayer human amniotic membrane (HAM) as a grafting material for the repair of mid-palate oronasal fistulas in seven Berlin minipigs. After two weeks, three animals had the fistulas repaired with multilayered HAM grafts, three had them repaired with a collagen-based dermal substitute (INTEGRA((R)), Integra Life Sciences, Plainsboro, NJ, USA), and one fistula was left untreated to serve as a control. Grafts were interposed between the oral and nasal mucosa, traversing the fistulas. After healing for 40 days, the pigs were killed for clinical, histological, and immunohistochemical examination. Two of the three fistulas closed with HAM were successful, the diameter of the third was reduced in size, and there was no change in the diameter of the fistula in the control. This study shows successful closure of oronasal fistulas in minipigs using interposed grafts of cryopreserved HAM, and offers promise as a simple and effective technique for tension-free closure of such fistulas.",
keywords = "Amnion, Animals, Chondroitin Sulfates, Collagen, Humans, Male, Nose Diseases, Oral Fistula, Respiratory Tract Fistula, Skin, Artificial, Swine, Swine, Miniature",
author = "Kesting, {Marco Rainer} and Loeffelbein, {Denys John} and Mariella Classen and Julia Slotta-Huspenina and Hasler, {Rafael Johannes} and Frank Jacobsen and Kilian Kreutzer and Sammy Al-Benna and Klaus-Dietrich Wolff and Lars Steinstraesser",
year = "2010",
month = mar,
doi = "10.1016/j.bjoms.2009.04.025",
language = "English",
volume = "48",
pages = "131–135",
journal = "BRIT J ORAL MAX SURG",
issn = "0266-4356",
publisher = "Churchill Livingstone",
number = "2",

}

RIS

TY - JOUR

T1 - Repair of oronasal fistulas with human amniotic membrane in minipigs

AU - Kesting, Marco Rainer

AU - Loeffelbein, Denys John

AU - Classen, Mariella

AU - Slotta-Huspenina, Julia

AU - Hasler, Rafael Johannes

AU - Jacobsen, Frank

AU - Kreutzer, Kilian

AU - Al-Benna, Sammy

AU - Wolff, Klaus-Dietrich

AU - Steinstraesser, Lars

PY - 2010/3

Y1 - 2010/3

N2 - We evaluated the use of multilayer human amniotic membrane (HAM) as a grafting material for the repair of mid-palate oronasal fistulas in seven Berlin minipigs. After two weeks, three animals had the fistulas repaired with multilayered HAM grafts, three had them repaired with a collagen-based dermal substitute (INTEGRA((R)), Integra Life Sciences, Plainsboro, NJ, USA), and one fistula was left untreated to serve as a control. Grafts were interposed between the oral and nasal mucosa, traversing the fistulas. After healing for 40 days, the pigs were killed for clinical, histological, and immunohistochemical examination. Two of the three fistulas closed with HAM were successful, the diameter of the third was reduced in size, and there was no change in the diameter of the fistula in the control. This study shows successful closure of oronasal fistulas in minipigs using interposed grafts of cryopreserved HAM, and offers promise as a simple and effective technique for tension-free closure of such fistulas.

AB - We evaluated the use of multilayer human amniotic membrane (HAM) as a grafting material for the repair of mid-palate oronasal fistulas in seven Berlin minipigs. After two weeks, three animals had the fistulas repaired with multilayered HAM grafts, three had them repaired with a collagen-based dermal substitute (INTEGRA((R)), Integra Life Sciences, Plainsboro, NJ, USA), and one fistula was left untreated to serve as a control. Grafts were interposed between the oral and nasal mucosa, traversing the fistulas. After healing for 40 days, the pigs were killed for clinical, histological, and immunohistochemical examination. Two of the three fistulas closed with HAM were successful, the diameter of the third was reduced in size, and there was no change in the diameter of the fistula in the control. This study shows successful closure of oronasal fistulas in minipigs using interposed grafts of cryopreserved HAM, and offers promise as a simple and effective technique for tension-free closure of such fistulas.

KW - Amnion

KW - Animals

KW - Chondroitin Sulfates

KW - Collagen

KW - Humans

KW - Male

KW - Nose Diseases

KW - Oral Fistula

KW - Respiratory Tract Fistula

KW - Skin, Artificial

KW - Swine

KW - Swine, Miniature

U2 - 10.1016/j.bjoms.2009.04.025

DO - 10.1016/j.bjoms.2009.04.025

M3 - SCORING: Journal article

C2 - 19477056

VL - 48

SP - 131

EP - 135

JO - BRIT J ORAL MAX SURG

JF - BRIT J ORAL MAX SURG

SN - 0266-4356

IS - 2

ER -