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Relationship between exercise intervention and NO pathway in patients with heart failure with preserved ejection fraction

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Relationship between exercise intervention and NO pathway in patients with heart failure with preserved ejection fraction. / Baldassarri, Flavia; Schwedhelm, Edzard; Atzler, Dorothee; Böger, Rainer H; Cordts, Kathrin; Haller, Bernhard; Pressler, Axel; Müller, Stephan; Suchy, Christiane; Wachter, Rolf; Düngen, Hans-Dirk; Hasenfuss, Gerd; Pieske, Burkert; Halle, Martin; Edelmann, Frank; Duvinage, André.

In: BIOMARKERS, Vol. 23, No. 6, 09.2018, p. 540-550.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Baldassarri, F, Schwedhelm, E, Atzler, D, Böger, RH, Cordts, K, Haller, B, Pressler, A, Müller, S, Suchy, C, Wachter, R, Düngen, H-D, Hasenfuss, G, Pieske, B, Halle, M, Edelmann, F & Duvinage, A 2018, 'Relationship between exercise intervention and NO pathway in patients with heart failure with preserved ejection fraction', BIOMARKERS, vol. 23, no. 6, pp. 540-550. https://doi.org/10.1080/1354750X.2018.1460762

APA

Baldassarri, F., Schwedhelm, E., Atzler, D., Böger, R. H., Cordts, K., Haller, B., Pressler, A., Müller, S., Suchy, C., Wachter, R., Düngen, H-D., Hasenfuss, G., Pieske, B., Halle, M., Edelmann, F., & Duvinage, A. (2018). Relationship between exercise intervention and NO pathway in patients with heart failure with preserved ejection fraction. BIOMARKERS, 23(6), 540-550. https://doi.org/10.1080/1354750X.2018.1460762

Vancouver

Baldassarri F, Schwedhelm E, Atzler D, Böger RH, Cordts K, Haller B et al. Relationship between exercise intervention and NO pathway in patients with heart failure with preserved ejection fraction. BIOMARKERS. 2018 Sep;23(6):540-550. https://doi.org/10.1080/1354750X.2018.1460762

Bibtex

@article{123c49132d4241718e6330ac1c221e9d,
title = "Relationship between exercise intervention and NO pathway in patients with heart failure with preserved ejection fraction",
abstract = "OBJECTIVE: Elevated levels of arginine derivatives in the NO pathway, such as asymmetric dimethylarginine (ADMA), are related to disease severity and reduced exercise capacity in heart failure (HF). We investigated the influence of exercise intervention on these parameters and on L-arginine (L-Arg) and L-homoarginine (L-hArg) in HF with preserved ejection fraction (HFpEF) patients.MATERIAL AND METHODS: Sixty-two patients (65 ± 6 years) were included in this analysis and randomized to supervised endurance/resistance training (ET) or to usual care (UC). EDTA-plasma was analysed for NO metabolites.RESULTS: There were baseline associations for adjusted values of maximum workload with ADMA (r= -0.322, p = 0.028) and L-Arg/ADMA ratio (r = 0.331, p = 0.015), and for the 6-min walk test (6MWT) with ADMA (r= -0.314, p = 0.024) and L-Arg/ADMA ratio (r = 0.346, p = 0.015). No significant differences between UC and ET changes of NO parameters were observed at 3-month follow-up. Higher L-hArg levels were associated with a greater improvement in peak oxygen uptake (peak [Formula: see text]O2) at follow-up: 3.4 ± 2.8 vs. 1.1 ± 2.9 mL/min/kg (p = 0.005).CONCLUSIONS: Exercise intervention did not influence NO parameters in HFpEF patients, but L-hArg was related to change in peak [Formula: see text]O2.",
keywords = "Aged, Arginine, Biomarkers, Exercise Therapy, Female, Follow-Up Studies, Heart Failure, Humans, Male, Middle Aged, Nitric Oxide, Prospective Studies, Signal Transduction, Stroke Volume, Journal Article, Multicenter Study, Randomized Controlled Trial",
author = "Flavia Baldassarri and Edzard Schwedhelm and Dorothee Atzler and B{\"o}ger, {Rainer H} and Kathrin Cordts and Bernhard Haller and Axel Pressler and Stephan M{\"u}ller and Christiane Suchy and Rolf Wachter and Hans-Dirk D{\"u}ngen and Gerd Hasenfuss and Burkert Pieske and Martin Halle and Frank Edelmann and Andr{\'e} Duvinage",
year = "2018",
month = sep,
doi = "10.1080/1354750X.2018.1460762",
language = "English",
volume = "23",
pages = "540--550",
journal = "BIOMARKERS",
issn = "1354-750X",
publisher = "informa healthcare",
number = "6",

}

RIS

TY - JOUR

T1 - Relationship between exercise intervention and NO pathway in patients with heart failure with preserved ejection fraction

AU - Baldassarri, Flavia

AU - Schwedhelm, Edzard

AU - Atzler, Dorothee

AU - Böger, Rainer H

AU - Cordts, Kathrin

AU - Haller, Bernhard

AU - Pressler, Axel

AU - Müller, Stephan

AU - Suchy, Christiane

AU - Wachter, Rolf

AU - Düngen, Hans-Dirk

AU - Hasenfuss, Gerd

AU - Pieske, Burkert

AU - Halle, Martin

AU - Edelmann, Frank

AU - Duvinage, André

PY - 2018/9

Y1 - 2018/9

N2 - OBJECTIVE: Elevated levels of arginine derivatives in the NO pathway, such as asymmetric dimethylarginine (ADMA), are related to disease severity and reduced exercise capacity in heart failure (HF). We investigated the influence of exercise intervention on these parameters and on L-arginine (L-Arg) and L-homoarginine (L-hArg) in HF with preserved ejection fraction (HFpEF) patients.MATERIAL AND METHODS: Sixty-two patients (65 ± 6 years) were included in this analysis and randomized to supervised endurance/resistance training (ET) or to usual care (UC). EDTA-plasma was analysed for NO metabolites.RESULTS: There were baseline associations for adjusted values of maximum workload with ADMA (r= -0.322, p = 0.028) and L-Arg/ADMA ratio (r = 0.331, p = 0.015), and for the 6-min walk test (6MWT) with ADMA (r= -0.314, p = 0.024) and L-Arg/ADMA ratio (r = 0.346, p = 0.015). No significant differences between UC and ET changes of NO parameters were observed at 3-month follow-up. Higher L-hArg levels were associated with a greater improvement in peak oxygen uptake (peak [Formula: see text]O2) at follow-up: 3.4 ± 2.8 vs. 1.1 ± 2.9 mL/min/kg (p = 0.005).CONCLUSIONS: Exercise intervention did not influence NO parameters in HFpEF patients, but L-hArg was related to change in peak [Formula: see text]O2.

AB - OBJECTIVE: Elevated levels of arginine derivatives in the NO pathway, such as asymmetric dimethylarginine (ADMA), are related to disease severity and reduced exercise capacity in heart failure (HF). We investigated the influence of exercise intervention on these parameters and on L-arginine (L-Arg) and L-homoarginine (L-hArg) in HF with preserved ejection fraction (HFpEF) patients.MATERIAL AND METHODS: Sixty-two patients (65 ± 6 years) were included in this analysis and randomized to supervised endurance/resistance training (ET) or to usual care (UC). EDTA-plasma was analysed for NO metabolites.RESULTS: There were baseline associations for adjusted values of maximum workload with ADMA (r= -0.322, p = 0.028) and L-Arg/ADMA ratio (r = 0.331, p = 0.015), and for the 6-min walk test (6MWT) with ADMA (r= -0.314, p = 0.024) and L-Arg/ADMA ratio (r = 0.346, p = 0.015). No significant differences between UC and ET changes of NO parameters were observed at 3-month follow-up. Higher L-hArg levels were associated with a greater improvement in peak oxygen uptake (peak [Formula: see text]O2) at follow-up: 3.4 ± 2.8 vs. 1.1 ± 2.9 mL/min/kg (p = 0.005).CONCLUSIONS: Exercise intervention did not influence NO parameters in HFpEF patients, but L-hArg was related to change in peak [Formula: see text]O2.

KW - Aged

KW - Arginine

KW - Biomarkers

KW - Exercise Therapy

KW - Female

KW - Follow-Up Studies

KW - Heart Failure

KW - Humans

KW - Male

KW - Middle Aged

KW - Nitric Oxide

KW - Prospective Studies

KW - Signal Transduction

KW - Stroke Volume

KW - Journal Article

KW - Multicenter Study

KW - Randomized Controlled Trial

U2 - 10.1080/1354750X.2018.1460762

DO - 10.1080/1354750X.2018.1460762

M3 - SCORING: Journal article

C2 - 29619838

VL - 23

SP - 540

EP - 550

JO - BIOMARKERS

JF - BIOMARKERS

SN - 1354-750X

IS - 6

ER -