Relationship between exercise intervention and NO pathway in patients with heart failure with preserved ejection fraction
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Relationship between exercise intervention and NO pathway in patients with heart failure with preserved ejection fraction. / Baldassarri, Flavia; Schwedhelm, Edzard; Atzler, Dorothee; Böger, Rainer H; Cordts, Kathrin; Haller, Bernhard; Pressler, Axel; Müller, Stephan; Suchy, Christiane; Wachter, Rolf; Düngen, Hans-Dirk; Hasenfuss, Gerd; Pieske, Burkert; Halle, Martin; Edelmann, Frank; Duvinage, André.
in: BIOMARKERS, Jahrgang 23, Nr. 6, 09.2018, S. 540-550.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Relationship between exercise intervention and NO pathway in patients with heart failure with preserved ejection fraction
AU - Baldassarri, Flavia
AU - Schwedhelm, Edzard
AU - Atzler, Dorothee
AU - Böger, Rainer H
AU - Cordts, Kathrin
AU - Haller, Bernhard
AU - Pressler, Axel
AU - Müller, Stephan
AU - Suchy, Christiane
AU - Wachter, Rolf
AU - Düngen, Hans-Dirk
AU - Hasenfuss, Gerd
AU - Pieske, Burkert
AU - Halle, Martin
AU - Edelmann, Frank
AU - Duvinage, André
PY - 2018/9
Y1 - 2018/9
N2 - OBJECTIVE: Elevated levels of arginine derivatives in the NO pathway, such as asymmetric dimethylarginine (ADMA), are related to disease severity and reduced exercise capacity in heart failure (HF). We investigated the influence of exercise intervention on these parameters and on L-arginine (L-Arg) and L-homoarginine (L-hArg) in HF with preserved ejection fraction (HFpEF) patients.MATERIAL AND METHODS: Sixty-two patients (65 ± 6 years) were included in this analysis and randomized to supervised endurance/resistance training (ET) or to usual care (UC). EDTA-plasma was analysed for NO metabolites.RESULTS: There were baseline associations for adjusted values of maximum workload with ADMA (r= -0.322, p = 0.028) and L-Arg/ADMA ratio (r = 0.331, p = 0.015), and for the 6-min walk test (6MWT) with ADMA (r= -0.314, p = 0.024) and L-Arg/ADMA ratio (r = 0.346, p = 0.015). No significant differences between UC and ET changes of NO parameters were observed at 3-month follow-up. Higher L-hArg levels were associated with a greater improvement in peak oxygen uptake (peak [Formula: see text]O2) at follow-up: 3.4 ± 2.8 vs. 1.1 ± 2.9 mL/min/kg (p = 0.005).CONCLUSIONS: Exercise intervention did not influence NO parameters in HFpEF patients, but L-hArg was related to change in peak [Formula: see text]O2.
AB - OBJECTIVE: Elevated levels of arginine derivatives in the NO pathway, such as asymmetric dimethylarginine (ADMA), are related to disease severity and reduced exercise capacity in heart failure (HF). We investigated the influence of exercise intervention on these parameters and on L-arginine (L-Arg) and L-homoarginine (L-hArg) in HF with preserved ejection fraction (HFpEF) patients.MATERIAL AND METHODS: Sixty-two patients (65 ± 6 years) were included in this analysis and randomized to supervised endurance/resistance training (ET) or to usual care (UC). EDTA-plasma was analysed for NO metabolites.RESULTS: There were baseline associations for adjusted values of maximum workload with ADMA (r= -0.322, p = 0.028) and L-Arg/ADMA ratio (r = 0.331, p = 0.015), and for the 6-min walk test (6MWT) with ADMA (r= -0.314, p = 0.024) and L-Arg/ADMA ratio (r = 0.346, p = 0.015). No significant differences between UC and ET changes of NO parameters were observed at 3-month follow-up. Higher L-hArg levels were associated with a greater improvement in peak oxygen uptake (peak [Formula: see text]O2) at follow-up: 3.4 ± 2.8 vs. 1.1 ± 2.9 mL/min/kg (p = 0.005).CONCLUSIONS: Exercise intervention did not influence NO parameters in HFpEF patients, but L-hArg was related to change in peak [Formula: see text]O2.
KW - Aged
KW - Arginine
KW - Biomarkers
KW - Exercise Therapy
KW - Female
KW - Follow-Up Studies
KW - Heart Failure
KW - Humans
KW - Male
KW - Middle Aged
KW - Nitric Oxide
KW - Prospective Studies
KW - Signal Transduction
KW - Stroke Volume
KW - Journal Article
KW - Multicenter Study
KW - Randomized Controlled Trial
U2 - 10.1080/1354750X.2018.1460762
DO - 10.1080/1354750X.2018.1460762
M3 - SCORING: Journal article
C2 - 29619838
VL - 23
SP - 540
EP - 550
JO - BIOMARKERS
JF - BIOMARKERS
SN - 1354-750X
IS - 6
ER -