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Relation between Arterial Stiffness and Markers of Inflammation and Hemostasis - Data from the Population-based Gutenberg Health Study

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Relation between Arterial Stiffness and Markers of Inflammation and Hemostasis - Data from the Population-based Gutenberg Health Study. / Arnold, Natalie; Gori, Tommaso; Schnabel, Renate B; Schulz, Andreas; Prochaska, Jürgen H; Zeller, Tanja; Binder, Harald; Pfeiffer, Norbert; Beutel, Manfred; Espinola-Klein, Christine; Lackner, Karl J; Blankenberg, Stefan; Münzel, Thomas; Wild, Philipp S.

In: SCI REP-UK, Vol. 7, No. 1, 6346, 24.07.2017.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Arnold, N, Gori, T, Schnabel, RB, Schulz, A, Prochaska, JH, Zeller, T, Binder, H, Pfeiffer, N, Beutel, M, Espinola-Klein, C, Lackner, KJ, Blankenberg, S, Münzel, T & Wild, PS 2017, 'Relation between Arterial Stiffness and Markers of Inflammation and Hemostasis - Data from the Population-based Gutenberg Health Study', SCI REP-UK, vol. 7, no. 1, 6346. https://doi.org/10.1038/s41598-017-06175-2

APA

Arnold, N., Gori, T., Schnabel, R. B., Schulz, A., Prochaska, J. H., Zeller, T., Binder, H., Pfeiffer, N., Beutel, M., Espinola-Klein, C., Lackner, K. J., Blankenberg, S., Münzel, T., & Wild, P. S. (2017). Relation between Arterial Stiffness and Markers of Inflammation and Hemostasis - Data from the Population-based Gutenberg Health Study. SCI REP-UK, 7(1), [6346]. https://doi.org/10.1038/s41598-017-06175-2

Vancouver

Arnold N, Gori T, Schnabel RB, Schulz A, Prochaska JH, Zeller T et al. Relation between Arterial Stiffness and Markers of Inflammation and Hemostasis - Data from the Population-based Gutenberg Health Study. SCI REP-UK. 2017 Jul 24;7(1). 6346. https://doi.org/10.1038/s41598-017-06175-2

Bibtex

@article{cbbee41336bf4779b11f1f8cb0c12a0b,
title = "Relation between Arterial Stiffness and Markers of Inflammation and Hemostasis - Data from the Population-based Gutenberg Health Study",
abstract = "The relation between inflammation, hemostasis and arterial stiffness is of pathophysiological relevance for the development of cardiovascular disease (CVD). Data investigating this interplay using stiffness index (SI) by digital photoplethysmography are not available yet. Therefore, sex-specific relation between SI and inflammatory and hemostatic biomarkers was investigated within 13,724 subjects from the population-based Gutenberg Health Study. C-reactive protein (CRP), white blood cell count (WBCC), neopterin, interleukin-18, interleukin-1 receptor antagonist (IL-1RA), fibrinogen and hematocrit were measured. Multivariable linear regression analysis with adjustment for cardiovascular risk factors, medication, and hormonal status (in females) revealed an independent association between SI and WBCC, IL-1RA and hematocrit in both sexes, and with fibrinogen in women. There was a joint effect of increasing tertiles of SI and biomarker concentrations for future CVD risk prediction. Subjects with both SI and biomarker concentration above the median had the worst overall survival and with both below the median the best survival during a follow-up period of 6.2 ± 1.7 years, except for hematocrit. The results support the relation between inflammation, hemostasis and arterial stiffness measured by digital photoplethysmography. Markers of inflammation and hemostasis modulate the ability of SI to identify subjects at risk for future CVD or higher mortality.",
keywords = "Adult, Aged, Biomarkers, C-Reactive Protein/metabolism, Cardiovascular Diseases/blood, Female, Fibrinogen/metabolism, Hemostasis, Humans, Inflammation Mediators/blood, Interleukin 1 Receptor Antagonist Protein/blood, Interleukin-18/blood, Leukocyte Count, Male, Middle Aged, Neopterin/blood, Prognosis, Prospective Studies, Risk Factors, Survival Analysis, Vascular Stiffness",
author = "Natalie Arnold and Tommaso Gori and Schnabel, {Renate B} and Andreas Schulz and Prochaska, {J{\"u}rgen H} and Tanja Zeller and Harald Binder and Norbert Pfeiffer and Manfred Beutel and Christine Espinola-Klein and Lackner, {Karl J} and Stefan Blankenberg and Thomas M{\"u}nzel and Wild, {Philipp S}",
year = "2017",
month = jul,
day = "24",
doi = "10.1038/s41598-017-06175-2",
language = "English",
volume = "7",
journal = "SCI REP-UK",
issn = "2045-2322",
publisher = "NATURE PUBLISHING GROUP",
number = "1",

}

RIS

TY - JOUR

T1 - Relation between Arterial Stiffness and Markers of Inflammation and Hemostasis - Data from the Population-based Gutenberg Health Study

AU - Arnold, Natalie

AU - Gori, Tommaso

AU - Schnabel, Renate B

AU - Schulz, Andreas

AU - Prochaska, Jürgen H

AU - Zeller, Tanja

AU - Binder, Harald

AU - Pfeiffer, Norbert

AU - Beutel, Manfred

AU - Espinola-Klein, Christine

AU - Lackner, Karl J

AU - Blankenberg, Stefan

AU - Münzel, Thomas

AU - Wild, Philipp S

PY - 2017/7/24

Y1 - 2017/7/24

N2 - The relation between inflammation, hemostasis and arterial stiffness is of pathophysiological relevance for the development of cardiovascular disease (CVD). Data investigating this interplay using stiffness index (SI) by digital photoplethysmography are not available yet. Therefore, sex-specific relation between SI and inflammatory and hemostatic biomarkers was investigated within 13,724 subjects from the population-based Gutenberg Health Study. C-reactive protein (CRP), white blood cell count (WBCC), neopterin, interleukin-18, interleukin-1 receptor antagonist (IL-1RA), fibrinogen and hematocrit were measured. Multivariable linear regression analysis with adjustment for cardiovascular risk factors, medication, and hormonal status (in females) revealed an independent association between SI and WBCC, IL-1RA and hematocrit in both sexes, and with fibrinogen in women. There was a joint effect of increasing tertiles of SI and biomarker concentrations for future CVD risk prediction. Subjects with both SI and biomarker concentration above the median had the worst overall survival and with both below the median the best survival during a follow-up period of 6.2 ± 1.7 years, except for hematocrit. The results support the relation between inflammation, hemostasis and arterial stiffness measured by digital photoplethysmography. Markers of inflammation and hemostasis modulate the ability of SI to identify subjects at risk for future CVD or higher mortality.

AB - The relation between inflammation, hemostasis and arterial stiffness is of pathophysiological relevance for the development of cardiovascular disease (CVD). Data investigating this interplay using stiffness index (SI) by digital photoplethysmography are not available yet. Therefore, sex-specific relation between SI and inflammatory and hemostatic biomarkers was investigated within 13,724 subjects from the population-based Gutenberg Health Study. C-reactive protein (CRP), white blood cell count (WBCC), neopterin, interleukin-18, interleukin-1 receptor antagonist (IL-1RA), fibrinogen and hematocrit were measured. Multivariable linear regression analysis with adjustment for cardiovascular risk factors, medication, and hormonal status (in females) revealed an independent association between SI and WBCC, IL-1RA and hematocrit in both sexes, and with fibrinogen in women. There was a joint effect of increasing tertiles of SI and biomarker concentrations for future CVD risk prediction. Subjects with both SI and biomarker concentration above the median had the worst overall survival and with both below the median the best survival during a follow-up period of 6.2 ± 1.7 years, except for hematocrit. The results support the relation between inflammation, hemostasis and arterial stiffness measured by digital photoplethysmography. Markers of inflammation and hemostasis modulate the ability of SI to identify subjects at risk for future CVD or higher mortality.

KW - Adult

KW - Aged

KW - Biomarkers

KW - C-Reactive Protein/metabolism

KW - Cardiovascular Diseases/blood

KW - Female

KW - Fibrinogen/metabolism

KW - Hemostasis

KW - Humans

KW - Inflammation Mediators/blood

KW - Interleukin 1 Receptor Antagonist Protein/blood

KW - Interleukin-18/blood

KW - Leukocyte Count

KW - Male

KW - Middle Aged

KW - Neopterin/blood

KW - Prognosis

KW - Prospective Studies

KW - Risk Factors

KW - Survival Analysis

KW - Vascular Stiffness

U2 - 10.1038/s41598-017-06175-2

DO - 10.1038/s41598-017-06175-2

M3 - SCORING: Journal article

C2 - 28740206

VL - 7

JO - SCI REP-UK

JF - SCI REP-UK

SN - 2045-2322

IS - 1

M1 - 6346

ER -