Relation between Arterial Stiffness and Markers of Inflammation and Hemostasis - Data from the Population-based Gutenberg Health Study
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Relation between Arterial Stiffness and Markers of Inflammation and Hemostasis - Data from the Population-based Gutenberg Health Study. / Arnold, Natalie; Gori, Tommaso; Schnabel, Renate B; Schulz, Andreas; Prochaska, Jürgen H; Zeller, Tanja; Binder, Harald; Pfeiffer, Norbert; Beutel, Manfred; Espinola-Klein, Christine; Lackner, Karl J; Blankenberg, Stefan; Münzel, Thomas; Wild, Philipp S.
in: SCI REP-UK, Jahrgang 7, Nr. 1, 6346, 24.07.2017.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Relation between Arterial Stiffness and Markers of Inflammation and Hemostasis - Data from the Population-based Gutenberg Health Study
AU - Arnold, Natalie
AU - Gori, Tommaso
AU - Schnabel, Renate B
AU - Schulz, Andreas
AU - Prochaska, Jürgen H
AU - Zeller, Tanja
AU - Binder, Harald
AU - Pfeiffer, Norbert
AU - Beutel, Manfred
AU - Espinola-Klein, Christine
AU - Lackner, Karl J
AU - Blankenberg, Stefan
AU - Münzel, Thomas
AU - Wild, Philipp S
PY - 2017/7/24
Y1 - 2017/7/24
N2 - The relation between inflammation, hemostasis and arterial stiffness is of pathophysiological relevance for the development of cardiovascular disease (CVD). Data investigating this interplay using stiffness index (SI) by digital photoplethysmography are not available yet. Therefore, sex-specific relation between SI and inflammatory and hemostatic biomarkers was investigated within 13,724 subjects from the population-based Gutenberg Health Study. C-reactive protein (CRP), white blood cell count (WBCC), neopterin, interleukin-18, interleukin-1 receptor antagonist (IL-1RA), fibrinogen and hematocrit were measured. Multivariable linear regression analysis with adjustment for cardiovascular risk factors, medication, and hormonal status (in females) revealed an independent association between SI and WBCC, IL-1RA and hematocrit in both sexes, and with fibrinogen in women. There was a joint effect of increasing tertiles of SI and biomarker concentrations for future CVD risk prediction. Subjects with both SI and biomarker concentration above the median had the worst overall survival and with both below the median the best survival during a follow-up period of 6.2 ± 1.7 years, except for hematocrit. The results support the relation between inflammation, hemostasis and arterial stiffness measured by digital photoplethysmography. Markers of inflammation and hemostasis modulate the ability of SI to identify subjects at risk for future CVD or higher mortality.
AB - The relation between inflammation, hemostasis and arterial stiffness is of pathophysiological relevance for the development of cardiovascular disease (CVD). Data investigating this interplay using stiffness index (SI) by digital photoplethysmography are not available yet. Therefore, sex-specific relation between SI and inflammatory and hemostatic biomarkers was investigated within 13,724 subjects from the population-based Gutenberg Health Study. C-reactive protein (CRP), white blood cell count (WBCC), neopterin, interleukin-18, interleukin-1 receptor antagonist (IL-1RA), fibrinogen and hematocrit were measured. Multivariable linear regression analysis with adjustment for cardiovascular risk factors, medication, and hormonal status (in females) revealed an independent association between SI and WBCC, IL-1RA and hematocrit in both sexes, and with fibrinogen in women. There was a joint effect of increasing tertiles of SI and biomarker concentrations for future CVD risk prediction. Subjects with both SI and biomarker concentration above the median had the worst overall survival and with both below the median the best survival during a follow-up period of 6.2 ± 1.7 years, except for hematocrit. The results support the relation between inflammation, hemostasis and arterial stiffness measured by digital photoplethysmography. Markers of inflammation and hemostasis modulate the ability of SI to identify subjects at risk for future CVD or higher mortality.
KW - Adult
KW - Aged
KW - Biomarkers
KW - C-Reactive Protein/metabolism
KW - Cardiovascular Diseases/blood
KW - Female
KW - Fibrinogen/metabolism
KW - Hemostasis
KW - Humans
KW - Inflammation Mediators/blood
KW - Interleukin 1 Receptor Antagonist Protein/blood
KW - Interleukin-18/blood
KW - Leukocyte Count
KW - Male
KW - Middle Aged
KW - Neopterin/blood
KW - Prognosis
KW - Prospective Studies
KW - Risk Factors
KW - Survival Analysis
KW - Vascular Stiffness
U2 - 10.1038/s41598-017-06175-2
DO - 10.1038/s41598-017-06175-2
M3 - SCORING: Journal article
C2 - 28740206
VL - 7
JO - SCI REP-UK
JF - SCI REP-UK
SN - 2045-2322
IS - 1
M1 - 6346
ER -