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Regulation of rat mesangial cell growth by diadenosine phosphates

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Regulation of rat mesangial cell growth by diadenosine phosphates. / Heidenreich, Stefan; Tepel, M; Schlüter, H; Harrach, B; Zidek, W; Heidenreich, Stefan.

In: J CLIN INVEST, Vol. 95, No. 6, 06.1995, p. 2862-7.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Heidenreich, S, Tepel, M, Schlüter, H, Harrach, B, Zidek, W & Heidenreich, S 1995, 'Regulation of rat mesangial cell growth by diadenosine phosphates', J CLIN INVEST, vol. 95, no. 6, pp. 2862-7. https://doi.org/10.1172/JCI117992

APA

Heidenreich, S., Tepel, M., Schlüter, H., Harrach, B., Zidek, W., & Heidenreich, S. (1995). Regulation of rat mesangial cell growth by diadenosine phosphates. J CLIN INVEST, 95(6), 2862-7. https://doi.org/10.1172/JCI117992

Vancouver

Heidenreich S, Tepel M, Schlüter H, Harrach B, Zidek W, Heidenreich S. Regulation of rat mesangial cell growth by diadenosine phosphates. J CLIN INVEST. 1995 Jun;95(6):2862-7. https://doi.org/10.1172/JCI117992

Bibtex

@article{35e571e5b0f84bf29819004c78a87409,
title = "Regulation of rat mesangial cell growth by diadenosine phosphates",
abstract = "The newly recognized human endogenous vasoconstrictive dinucleotides, diadenosine pentaphosphate (AP5A) and diadenosine hexaphosphate (AP6A), were tested for growth stimulatory effects in rat mesangial cells (MC). Both AP5A and AP6A stimulated growth in micromolar concentrations. The growth stimulatory effect exceeded that of ATP, alpha,beta-methylene ATP, adenosine 5'-O-(3-thio)triphosphate and UTP. Both diadenosine phosphates potentiated the growth response to platelet-derived growth factor, but not to insulin-like growth factor-1. To further elucidate the site of action in the cell cycle, RNA and protein synthesis were assessed. AP5 and AP6A stimulated protein synthesis, but not RNA formation. Furthermore, both agents increased cytosolic free Ca2+ concentration. It is concluded that AP5A and AP6A may play a regulatory role in MC growth as progression factors and possibly modify MC proliferation in glomerular disease.",
keywords = "Adenosine, Adenosine Triphosphate, Animals, Calcium, Cell Division, Cells, Cultured, DNA, Dinucleoside Phosphates, Drug Synergism, Glomerular Mesangium, In Vitro Techniques, Male, Platelet-Derived Growth Factor, Rats, Rats, Inbred WKY, Uridine Triphosphate, Journal Article, Research Support, Non-U.S. Gov't",
author = "Stefan Heidenreich and M Tepel and H Schl{\"u}ter and B Harrach and W Zidek and Stefan Heidenreich",
year = "1995",
month = jun,
doi = "10.1172/JCI117992",
language = "English",
volume = "95",
pages = "2862--7",
journal = "J CLIN INVEST",
issn = "0021-9738",
publisher = "The American Society for Clinical Investigation",
number = "6",

}

RIS

TY - JOUR

T1 - Regulation of rat mesangial cell growth by diadenosine phosphates

AU - Heidenreich, Stefan

AU - Tepel, M

AU - Schlüter, H

AU - Harrach, B

AU - Zidek, W

AU - Heidenreich, Stefan

PY - 1995/6

Y1 - 1995/6

N2 - The newly recognized human endogenous vasoconstrictive dinucleotides, diadenosine pentaphosphate (AP5A) and diadenosine hexaphosphate (AP6A), were tested for growth stimulatory effects in rat mesangial cells (MC). Both AP5A and AP6A stimulated growth in micromolar concentrations. The growth stimulatory effect exceeded that of ATP, alpha,beta-methylene ATP, adenosine 5'-O-(3-thio)triphosphate and UTP. Both diadenosine phosphates potentiated the growth response to platelet-derived growth factor, but not to insulin-like growth factor-1. To further elucidate the site of action in the cell cycle, RNA and protein synthesis were assessed. AP5 and AP6A stimulated protein synthesis, but not RNA formation. Furthermore, both agents increased cytosolic free Ca2+ concentration. It is concluded that AP5A and AP6A may play a regulatory role in MC growth as progression factors and possibly modify MC proliferation in glomerular disease.

AB - The newly recognized human endogenous vasoconstrictive dinucleotides, diadenosine pentaphosphate (AP5A) and diadenosine hexaphosphate (AP6A), were tested for growth stimulatory effects in rat mesangial cells (MC). Both AP5A and AP6A stimulated growth in micromolar concentrations. The growth stimulatory effect exceeded that of ATP, alpha,beta-methylene ATP, adenosine 5'-O-(3-thio)triphosphate and UTP. Both diadenosine phosphates potentiated the growth response to platelet-derived growth factor, but not to insulin-like growth factor-1. To further elucidate the site of action in the cell cycle, RNA and protein synthesis were assessed. AP5 and AP6A stimulated protein synthesis, but not RNA formation. Furthermore, both agents increased cytosolic free Ca2+ concentration. It is concluded that AP5A and AP6A may play a regulatory role in MC growth as progression factors and possibly modify MC proliferation in glomerular disease.

KW - Adenosine

KW - Adenosine Triphosphate

KW - Animals

KW - Calcium

KW - Cell Division

KW - Cells, Cultured

KW - DNA

KW - Dinucleoside Phosphates

KW - Drug Synergism

KW - Glomerular Mesangium

KW - In Vitro Techniques

KW - Male

KW - Platelet-Derived Growth Factor

KW - Rats

KW - Rats, Inbred WKY

KW - Uridine Triphosphate

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1172/JCI117992

DO - 10.1172/JCI117992

M3 - SCORING: Journal article

C2 - 7769127

VL - 95

SP - 2862

EP - 2867

JO - J CLIN INVEST

JF - J CLIN INVEST

SN - 0021-9738

IS - 6

ER -