Research ExplorerPublicationsReducing Distress from Auditory Verbal Hallucinations

Reducing Distress from Auditory Verbal Hallucinations

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Reducing Distress from Auditory Verbal Hallucinations : A Multicenter, Parallel, Single-Blind, Randomized Controlled Feasibility Trial of Relating Therapy. / Lincoln, Tania Marie; Schlier, Björn; Müller, Rebecca; Hayward, Mark; Fladung, Anne-Katharina; Bergmann, Niklas; Böge, Kerem; Gallinat, Jürgen; Mahlke, Candelaria; Gonther, Uwe; Lang, Thomas; Exner, Cornelia; Buchholz, Anika; Stahlmann, Katharina; Zapf, Antonia; Rauch, Geraldine; Pillny, Matthias.

In: PSYCHOTHER PSYCHOSOM, Vol. 93, No. 5, 2024, p. 328-339.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Lincoln, TM, Schlier, B, Müller, R, Hayward, M, Fladung, A-K, Bergmann, N, Böge, K, Gallinat, J, Mahlke, C, Gonther, U, Lang, T, Exner, C, Buchholz, A, Stahlmann, K, Zapf, A, Rauch, G & Pillny, M 2024, 'Reducing Distress from Auditory Verbal Hallucinations: A Multicenter, Parallel, Single-Blind, Randomized Controlled Feasibility Trial of Relating Therapy', PSYCHOTHER PSYCHOSOM, vol. 93, no. 5, pp. 328-339. https://doi.org/10.1159/000539809

APA

Lincoln, T. M., Schlier, B., Müller, R., Hayward, M., Fladung, A-K., Bergmann, N., Böge, K., Gallinat, J., Mahlke, C., Gonther, U., Lang, T., Exner, C., Buchholz, A., Stahlmann, K., Zapf, A., Rauch, G., & Pillny, M. (2024). Reducing Distress from Auditory Verbal Hallucinations: A Multicenter, Parallel, Single-Blind, Randomized Controlled Feasibility Trial of Relating Therapy. PSYCHOTHER PSYCHOSOM, 93(5), 328-339. https://doi.org/10.1159/000539809

Vancouver

Lincoln TM, Schlier B, Müller R, Hayward M, Fladung A-K, Bergmann N et al. Reducing Distress from Auditory Verbal Hallucinations: A Multicenter, Parallel, Single-Blind, Randomized Controlled Feasibility Trial of Relating Therapy. PSYCHOTHER PSYCHOSOM. 2024;93(5):328-339. https://doi.org/10.1159/000539809

Bibtex

@article{d2f934464e324c1bbfe7a6298f237f27,
title = "Reducing Distress from Auditory Verbal Hallucinations: A Multicenter, Parallel, Single-Blind, Randomized Controlled Feasibility Trial of Relating Therapy",
abstract = "INTRODUCTION: There is a significant demand for interventions that reduce distress related to auditory verbal hallucinations (AVHs). AVH distress is associated with the way voice hearers relate with AVHs. We aimed to establish the feasibility of a randomized controlled trial to demonstrate that adding {"}Relating Therapy{"} (RT) to treatment as usual (TAU) is superior to TAU in reducing AVH distress.METHODS: We conducted a multicenter, parallel, single-blind, randomized controlled feasibility trial in five mental health centers in Germany. Participants were ≥19 years of age, had persistent and distressing AVHs, and had a diagnosis of a schizophrenia-spectrum disorder. RT was delivered over a maximum of 16 sessions within 5 months. Blind assessments were conducted at baseline and at 5 and 9 months. Feasibility outcomes were the number of patients recruited and retained, and safety and therapist adherence. The primary endpoint was the distress factor score of the AVH subscale of the Psychotic Symptoms Rating Scales at 9 months.RESULTS: Eighty-five of 177 enrolled participants were randomized into RT + TAU (n = 43) or TAU (n = 42). Feasibility was excellent with 87% retention at 9 months, 86% reaching treatment uptake criteria, 98% therapist adherence, and no unexpected serious adverse reactions. Compared to TAU, RT + TAU showed nonsignificant trends toward less AVH distress (b = -2.40, SE = 1.52, p = 0.121, 90% CI (-4.94 to 0.15) and stronger improvement on all but one of the secondary outcomes.CONCLUSION: A randomized controlled trial of RT is feasible, safe, and well accepted. Our results provide an encouraging basis to further test the efficacy of RT in a definitive multicenter trial.",
author = "Lincoln, {Tania Marie} and Bj{\"o}rn Schlier and Rebecca M{\"u}ller and Mark Hayward and Anne-Katharina Fladung and Niklas Bergmann and Kerem B{\"o}ge and J{\"u}rgen Gallinat and Candelaria Mahlke and Uwe Gonther and Thomas Lang and Cornelia Exner and Anika Buchholz and Katharina Stahlmann and Antonia Zapf and Geraldine Rauch and Matthias Pillny",
note = "{\textcopyright} 2024 The Author(s). Published by S. Karger AG, Basel.",
year = "2024",
doi = "10.1159/000539809",
language = "English",
volume = "93",
pages = "328--339",
journal = "PSYCHOTHER PSYCHOSOM",
issn = "0033-3190",
publisher = "S. Karger AG",
number = "5",

}

RIS

TY - JOUR

T1 - Reducing Distress from Auditory Verbal Hallucinations

T2 - A Multicenter, Parallel, Single-Blind, Randomized Controlled Feasibility Trial of Relating Therapy

AU - Lincoln, Tania Marie

AU - Schlier, Björn

AU - Müller, Rebecca

AU - Hayward, Mark

AU - Fladung, Anne-Katharina

AU - Bergmann, Niklas

AU - Böge, Kerem

AU - Gallinat, Jürgen

AU - Mahlke, Candelaria

AU - Gonther, Uwe

AU - Lang, Thomas

AU - Exner, Cornelia

AU - Buchholz, Anika

AU - Stahlmann, Katharina

AU - Zapf, Antonia

AU - Rauch, Geraldine

AU - Pillny, Matthias

N1 - © 2024 The Author(s). Published by S. Karger AG, Basel.

PY - 2024

Y1 - 2024

N2 - INTRODUCTION: There is a significant demand for interventions that reduce distress related to auditory verbal hallucinations (AVHs). AVH distress is associated with the way voice hearers relate with AVHs. We aimed to establish the feasibility of a randomized controlled trial to demonstrate that adding "Relating Therapy" (RT) to treatment as usual (TAU) is superior to TAU in reducing AVH distress.METHODS: We conducted a multicenter, parallel, single-blind, randomized controlled feasibility trial in five mental health centers in Germany. Participants were ≥19 years of age, had persistent and distressing AVHs, and had a diagnosis of a schizophrenia-spectrum disorder. RT was delivered over a maximum of 16 sessions within 5 months. Blind assessments were conducted at baseline and at 5 and 9 months. Feasibility outcomes were the number of patients recruited and retained, and safety and therapist adherence. The primary endpoint was the distress factor score of the AVH subscale of the Psychotic Symptoms Rating Scales at 9 months.RESULTS: Eighty-five of 177 enrolled participants were randomized into RT + TAU (n = 43) or TAU (n = 42). Feasibility was excellent with 87% retention at 9 months, 86% reaching treatment uptake criteria, 98% therapist adherence, and no unexpected serious adverse reactions. Compared to TAU, RT + TAU showed nonsignificant trends toward less AVH distress (b = -2.40, SE = 1.52, p = 0.121, 90% CI (-4.94 to 0.15) and stronger improvement on all but one of the secondary outcomes.CONCLUSION: A randomized controlled trial of RT is feasible, safe, and well accepted. Our results provide an encouraging basis to further test the efficacy of RT in a definitive multicenter trial.

AB - INTRODUCTION: There is a significant demand for interventions that reduce distress related to auditory verbal hallucinations (AVHs). AVH distress is associated with the way voice hearers relate with AVHs. We aimed to establish the feasibility of a randomized controlled trial to demonstrate that adding "Relating Therapy" (RT) to treatment as usual (TAU) is superior to TAU in reducing AVH distress.METHODS: We conducted a multicenter, parallel, single-blind, randomized controlled feasibility trial in five mental health centers in Germany. Participants were ≥19 years of age, had persistent and distressing AVHs, and had a diagnosis of a schizophrenia-spectrum disorder. RT was delivered over a maximum of 16 sessions within 5 months. Blind assessments were conducted at baseline and at 5 and 9 months. Feasibility outcomes were the number of patients recruited and retained, and safety and therapist adherence. The primary endpoint was the distress factor score of the AVH subscale of the Psychotic Symptoms Rating Scales at 9 months.RESULTS: Eighty-five of 177 enrolled participants were randomized into RT + TAU (n = 43) or TAU (n = 42). Feasibility was excellent with 87% retention at 9 months, 86% reaching treatment uptake criteria, 98% therapist adherence, and no unexpected serious adverse reactions. Compared to TAU, RT + TAU showed nonsignificant trends toward less AVH distress (b = -2.40, SE = 1.52, p = 0.121, 90% CI (-4.94 to 0.15) and stronger improvement on all but one of the secondary outcomes.CONCLUSION: A randomized controlled trial of RT is feasible, safe, and well accepted. Our results provide an encouraging basis to further test the efficacy of RT in a definitive multicenter trial.

U2 - 10.1159/000539809

DO - 10.1159/000539809

M3 - SCORING: Journal article

C2 - 39168112

VL - 93

SP - 328

EP - 339

JO - PSYCHOTHER PSYCHOSOM

JF - PSYCHOTHER PSYCHOSOM

SN - 0033-3190

IS - 5

ER -