Reducing Distress from Auditory Verbal Hallucinations
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Reducing Distress from Auditory Verbal Hallucinations : A Multicenter, Parallel, Single-Blind, Randomized Controlled Feasibility Trial of Relating Therapy. / Lincoln, Tania Marie; Schlier, Björn; Müller, Rebecca; Hayward, Mark; Fladung, Anne-Katharina; Bergmann, Niklas; Böge, Kerem; Gallinat, Jürgen; Mahlke, Candelaria; Gonther, Uwe; Lang, Thomas; Exner, Cornelia; Buchholz, Anika; Stahlmann, Katharina; Zapf, Antonia; Rauch, Geraldine; Pillny, Matthias.
in: PSYCHOTHER PSYCHOSOM, Jahrgang 93, Nr. 5, 2024, S. 328-339.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Reducing Distress from Auditory Verbal Hallucinations
T2 - A Multicenter, Parallel, Single-Blind, Randomized Controlled Feasibility Trial of Relating Therapy
AU - Lincoln, Tania Marie
AU - Schlier, Björn
AU - Müller, Rebecca
AU - Hayward, Mark
AU - Fladung, Anne-Katharina
AU - Bergmann, Niklas
AU - Böge, Kerem
AU - Gallinat, Jürgen
AU - Mahlke, Candelaria
AU - Gonther, Uwe
AU - Lang, Thomas
AU - Exner, Cornelia
AU - Buchholz, Anika
AU - Stahlmann, Katharina
AU - Zapf, Antonia
AU - Rauch, Geraldine
AU - Pillny, Matthias
N1 - © 2024 The Author(s). Published by S. Karger AG, Basel.
PY - 2024
Y1 - 2024
N2 - INTRODUCTION: There is a significant demand for interventions that reduce distress related to auditory verbal hallucinations (AVHs). AVH distress is associated with the way voice hearers relate with AVHs. We aimed to establish the feasibility of a randomized controlled trial to demonstrate that adding "Relating Therapy" (RT) to treatment as usual (TAU) is superior to TAU in reducing AVH distress.METHODS: We conducted a multicenter, parallel, single-blind, randomized controlled feasibility trial in five mental health centers in Germany. Participants were ≥19 years of age, had persistent and distressing AVHs, and had a diagnosis of a schizophrenia-spectrum disorder. RT was delivered over a maximum of 16 sessions within 5 months. Blind assessments were conducted at baseline and at 5 and 9 months. Feasibility outcomes were the number of patients recruited and retained, and safety and therapist adherence. The primary endpoint was the distress factor score of the AVH subscale of the Psychotic Symptoms Rating Scales at 9 months.RESULTS: Eighty-five of 177 enrolled participants were randomized into RT + TAU (n = 43) or TAU (n = 42). Feasibility was excellent with 87% retention at 9 months, 86% reaching treatment uptake criteria, 98% therapist adherence, and no unexpected serious adverse reactions. Compared to TAU, RT + TAU showed nonsignificant trends toward less AVH distress (b = -2.40, SE = 1.52, p = 0.121, 90% CI (-4.94 to 0.15) and stronger improvement on all but one of the secondary outcomes.CONCLUSION: A randomized controlled trial of RT is feasible, safe, and well accepted. Our results provide an encouraging basis to further test the efficacy of RT in a definitive multicenter trial.
AB - INTRODUCTION: There is a significant demand for interventions that reduce distress related to auditory verbal hallucinations (AVHs). AVH distress is associated with the way voice hearers relate with AVHs. We aimed to establish the feasibility of a randomized controlled trial to demonstrate that adding "Relating Therapy" (RT) to treatment as usual (TAU) is superior to TAU in reducing AVH distress.METHODS: We conducted a multicenter, parallel, single-blind, randomized controlled feasibility trial in five mental health centers in Germany. Participants were ≥19 years of age, had persistent and distressing AVHs, and had a diagnosis of a schizophrenia-spectrum disorder. RT was delivered over a maximum of 16 sessions within 5 months. Blind assessments were conducted at baseline and at 5 and 9 months. Feasibility outcomes were the number of patients recruited and retained, and safety and therapist adherence. The primary endpoint was the distress factor score of the AVH subscale of the Psychotic Symptoms Rating Scales at 9 months.RESULTS: Eighty-five of 177 enrolled participants were randomized into RT + TAU (n = 43) or TAU (n = 42). Feasibility was excellent with 87% retention at 9 months, 86% reaching treatment uptake criteria, 98% therapist adherence, and no unexpected serious adverse reactions. Compared to TAU, RT + TAU showed nonsignificant trends toward less AVH distress (b = -2.40, SE = 1.52, p = 0.121, 90% CI (-4.94 to 0.15) and stronger improvement on all but one of the secondary outcomes.CONCLUSION: A randomized controlled trial of RT is feasible, safe, and well accepted. Our results provide an encouraging basis to further test the efficacy of RT in a definitive multicenter trial.
U2 - 10.1159/000539809
DO - 10.1159/000539809
M3 - SCORING: Journal article
C2 - 39168112
VL - 93
SP - 328
EP - 339
JO - PSYCHOTHER PSYCHOSOM
JF - PSYCHOTHER PSYCHOSOM
SN - 0033-3190
IS - 5
ER -