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Redifferentiation of chondrocytes and cartilage formation under intermittent hydrostatic pressure.

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Redifferentiation of chondrocytes and cartilage formation under intermittent hydrostatic pressure. / Heyland, Jan; Wiegandt, Katharina; Goepfert, Christiane; Nagel-Heyer, Stefanie; Ilinich, Eduard; Schumacher, Udo; Pörtner, Ralf.

In: BIOTECHNOL LETT, Vol. 28, No. 20, 20, 2006, p. 1641-1648.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Heyland, J, Wiegandt, K, Goepfert, C, Nagel-Heyer, S, Ilinich, E, Schumacher, U & Pörtner, R 2006, 'Redifferentiation of chondrocytes and cartilage formation under intermittent hydrostatic pressure.', BIOTECHNOL LETT, vol. 28, no. 20, 20, pp. 1641-1648. <http://www.ncbi.nlm.nih.gov/pubmed/16902847?dopt=Citation>

APA

Heyland, J., Wiegandt, K., Goepfert, C., Nagel-Heyer, S., Ilinich, E., Schumacher, U., & Pörtner, R. (2006). Redifferentiation of chondrocytes and cartilage formation under intermittent hydrostatic pressure. BIOTECHNOL LETT, 28(20), 1641-1648. [20]. http://www.ncbi.nlm.nih.gov/pubmed/16902847?dopt=Citation

Vancouver

Heyland J, Wiegandt K, Goepfert C, Nagel-Heyer S, Ilinich E, Schumacher U et al. Redifferentiation of chondrocytes and cartilage formation under intermittent hydrostatic pressure. BIOTECHNOL LETT. 2006;28(20):1641-1648. 20.

Bibtex

@article{f865477206e14cf3ac5ae5b85b9d9298,
title = "Redifferentiation of chondrocytes and cartilage formation under intermittent hydrostatic pressure.",
abstract = "Since articular cartilage is subjected to varying loads in vivo and undergoes cyclic hydrostatic pressure during periods of loading, it is hypothesized that mimicking these in vivo conditions can enhance synthesis of important matrix components during cultivation in vitro. Thus, the influence of intermittent loading during redifferentiation of chondrocytes in alginate beads, and during cartilage formation was investigated. A statistically significant increased synthesis of glycosaminoglycan and collagen type II during redifferentiation of chondrocytes embedded in alginate beads, as well as an increase in glycosaminoglycan content of tissue-engineered cartilage, was found compared to control without load. Immunohistological staining indicated qualitatively a high expression of collagen type II for both cases.",
author = "Jan Heyland and Katharina Wiegandt and Christiane Goepfert and Stefanie Nagel-Heyer and Eduard Ilinich and Udo Schumacher and Ralf P{\"o}rtner",
year = "2006",
language = "Deutsch",
volume = "28",
pages = "1641--1648",
journal = "BIOTECHNOL LETT",
issn = "0141-5492",
publisher = "Springer Netherlands",
number = "20",

}

RIS

TY - JOUR

T1 - Redifferentiation of chondrocytes and cartilage formation under intermittent hydrostatic pressure.

AU - Heyland, Jan

AU - Wiegandt, Katharina

AU - Goepfert, Christiane

AU - Nagel-Heyer, Stefanie

AU - Ilinich, Eduard

AU - Schumacher, Udo

AU - Pörtner, Ralf

PY - 2006

Y1 - 2006

N2 - Since articular cartilage is subjected to varying loads in vivo and undergoes cyclic hydrostatic pressure during periods of loading, it is hypothesized that mimicking these in vivo conditions can enhance synthesis of important matrix components during cultivation in vitro. Thus, the influence of intermittent loading during redifferentiation of chondrocytes in alginate beads, and during cartilage formation was investigated. A statistically significant increased synthesis of glycosaminoglycan and collagen type II during redifferentiation of chondrocytes embedded in alginate beads, as well as an increase in glycosaminoglycan content of tissue-engineered cartilage, was found compared to control without load. Immunohistological staining indicated qualitatively a high expression of collagen type II for both cases.

AB - Since articular cartilage is subjected to varying loads in vivo and undergoes cyclic hydrostatic pressure during periods of loading, it is hypothesized that mimicking these in vivo conditions can enhance synthesis of important matrix components during cultivation in vitro. Thus, the influence of intermittent loading during redifferentiation of chondrocytes in alginate beads, and during cartilage formation was investigated. A statistically significant increased synthesis of glycosaminoglycan and collagen type II during redifferentiation of chondrocytes embedded in alginate beads, as well as an increase in glycosaminoglycan content of tissue-engineered cartilage, was found compared to control without load. Immunohistological staining indicated qualitatively a high expression of collagen type II for both cases.

M3 - SCORING: Zeitschriftenaufsatz

VL - 28

SP - 1641

EP - 1648

JO - BIOTECHNOL LETT

JF - BIOTECHNOL LETT

SN - 0141-5492

IS - 20

M1 - 20

ER -