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Recent insights into the role of L1CAM in cancer initiation and progression

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Recent insights into the role of L1CAM in cancer initiation and progression. / Altevogt, Peter; Ben-Ze'ev, Avri; Gavert, Nancy; Schumacher, Udo; Schäfer, Heiner; Sebens, Susanne.

In: INT J CANCER, Vol. 147, No. 12, 15.12.2020, p. 3292 - 3296.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Altevogt, P, Ben-Ze'ev, A, Gavert, N, Schumacher, U, Schäfer, H & Sebens, S 2020, 'Recent insights into the role of L1CAM in cancer initiation and progression', INT J CANCER, vol. 147, no. 12, pp. 3292 - 3296. https://doi.org/10.1002/ijc.33177

APA

Altevogt, P., Ben-Ze'ev, A., Gavert, N., Schumacher, U., Schäfer, H., & Sebens, S. (2020). Recent insights into the role of L1CAM in cancer initiation and progression. INT J CANCER, 147(12), 3292 - 3296. https://doi.org/10.1002/ijc.33177

Vancouver

Altevogt P, Ben-Ze'ev A, Gavert N, Schumacher U, Schäfer H, Sebens S. Recent insights into the role of L1CAM in cancer initiation and progression. INT J CANCER. 2020 Dec 15;147(12):3292 - 3296. https://doi.org/10.1002/ijc.33177

Bibtex

@article{755ac3b5534a4d6bbe6b2321a5e0b4f0,
title = "Recent insights into the role of L1CAM in cancer initiation and progression",
abstract = "First described as a neuronal cell adhesion molecule, L1CAM was later identified to be present at increased levels in primary tumors and metastases of various types of cancer. Here, we describe the multifaceted roles of L1CAM that are involved in diverse fundamental steps during tumor initiation and progression, as well as in chemoresistance. Recently, Ganesh et al reported that L1CAM identifies metastasis-initiating cells in colorectal carcinoma exhibiting stem-like cell features, increased tumorigenic potential and enhanced chemoresistance. In this review, we highlight recent advances in L1CAM research with particular emphasis on its role in de-differentiation processes and cancer cell stemness supporting the view that L1CAM is a powerful prognostic factor and a suitable target for improved therapy of metastatic and drug-resistant tumors.",
author = "Peter Altevogt and Avri Ben-Ze'ev and Nancy Gavert and Udo Schumacher and Heiner Sch{\"a}fer and Susanne Sebens",
note = "{\textcopyright} 2020 UICC.",
year = "2020",
month = dec,
day = "15",
doi = "10.1002/ijc.33177",
language = "English",
volume = "147",
pages = "3292 -- 3296",
journal = "INT J CANCER",
issn = "0020-7136",
publisher = "Wiley-Liss Inc.",
number = "12",

}

RIS

TY - JOUR

T1 - Recent insights into the role of L1CAM in cancer initiation and progression

AU - Altevogt, Peter

AU - Ben-Ze'ev, Avri

AU - Gavert, Nancy

AU - Schumacher, Udo

AU - Schäfer, Heiner

AU - Sebens, Susanne

N1 - © 2020 UICC.

PY - 2020/12/15

Y1 - 2020/12/15

N2 - First described as a neuronal cell adhesion molecule, L1CAM was later identified to be present at increased levels in primary tumors and metastases of various types of cancer. Here, we describe the multifaceted roles of L1CAM that are involved in diverse fundamental steps during tumor initiation and progression, as well as in chemoresistance. Recently, Ganesh et al reported that L1CAM identifies metastasis-initiating cells in colorectal carcinoma exhibiting stem-like cell features, increased tumorigenic potential and enhanced chemoresistance. In this review, we highlight recent advances in L1CAM research with particular emphasis on its role in de-differentiation processes and cancer cell stemness supporting the view that L1CAM is a powerful prognostic factor and a suitable target for improved therapy of metastatic and drug-resistant tumors.

AB - First described as a neuronal cell adhesion molecule, L1CAM was later identified to be present at increased levels in primary tumors and metastases of various types of cancer. Here, we describe the multifaceted roles of L1CAM that are involved in diverse fundamental steps during tumor initiation and progression, as well as in chemoresistance. Recently, Ganesh et al reported that L1CAM identifies metastasis-initiating cells in colorectal carcinoma exhibiting stem-like cell features, increased tumorigenic potential and enhanced chemoresistance. In this review, we highlight recent advances in L1CAM research with particular emphasis on its role in de-differentiation processes and cancer cell stemness supporting the view that L1CAM is a powerful prognostic factor and a suitable target for improved therapy of metastatic and drug-resistant tumors.

U2 - 10.1002/ijc.33177

DO - 10.1002/ijc.33177

M3 - SCORING: Review article

C2 - 32588424

VL - 147

SP - 3292

EP - 3296

JO - INT J CANCER

JF - INT J CANCER

SN - 0020-7136

IS - 12

ER -