Recent insights into the role of L1CAM in cancer initiation and progression
Standard
Recent insights into the role of L1CAM in cancer initiation and progression. / Altevogt, Peter; Ben-Ze'ev, Avri; Gavert, Nancy; Schumacher, Udo; Schäfer, Heiner; Sebens, Susanne.
in: INT J CANCER, Jahrgang 147, Nr. 12, 15.12.2020, S. 3292 - 3296.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Recent insights into the role of L1CAM in cancer initiation and progression
AU - Altevogt, Peter
AU - Ben-Ze'ev, Avri
AU - Gavert, Nancy
AU - Schumacher, Udo
AU - Schäfer, Heiner
AU - Sebens, Susanne
N1 - © 2020 UICC.
PY - 2020/12/15
Y1 - 2020/12/15
N2 - First described as a neuronal cell adhesion molecule, L1CAM was later identified to be present at increased levels in primary tumors and metastases of various types of cancer. Here, we describe the multifaceted roles of L1CAM that are involved in diverse fundamental steps during tumor initiation and progression, as well as in chemoresistance. Recently, Ganesh et al reported that L1CAM identifies metastasis-initiating cells in colorectal carcinoma exhibiting stem-like cell features, increased tumorigenic potential and enhanced chemoresistance. In this review, we highlight recent advances in L1CAM research with particular emphasis on its role in de-differentiation processes and cancer cell stemness supporting the view that L1CAM is a powerful prognostic factor and a suitable target for improved therapy of metastatic and drug-resistant tumors.
AB - First described as a neuronal cell adhesion molecule, L1CAM was later identified to be present at increased levels in primary tumors and metastases of various types of cancer. Here, we describe the multifaceted roles of L1CAM that are involved in diverse fundamental steps during tumor initiation and progression, as well as in chemoresistance. Recently, Ganesh et al reported that L1CAM identifies metastasis-initiating cells in colorectal carcinoma exhibiting stem-like cell features, increased tumorigenic potential and enhanced chemoresistance. In this review, we highlight recent advances in L1CAM research with particular emphasis on its role in de-differentiation processes and cancer cell stemness supporting the view that L1CAM is a powerful prognostic factor and a suitable target for improved therapy of metastatic and drug-resistant tumors.
U2 - 10.1002/ijc.33177
DO - 10.1002/ijc.33177
M3 - SCORING: Review article
C2 - 32588424
VL - 147
SP - 3292
EP - 3296
JO - INT J CANCER
JF - INT J CANCER
SN - 0020-7136
IS - 12
ER -