Recent developments and current concepts in medulloblastoma

N U Gerber; M Mynarek; K von Hoff; C Friedrich; A Resch; S Rutkowski

doi:10.1016/j.ctrv.2013.11.010

Recent developments and current concepts in medulloblastoma

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Recent developments and current concepts in medulloblastoma. / Gerber, N U; Mynarek, M; von Hoff, K; Friedrich, C; Resch, A; Rutkowski, S.

In: CANCER TREAT REV, Vol. 40, No. 3, 01.04.2014, p. 356-365.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Gerber, NU, Mynarek, M, von Hoff, K, Friedrich, C, Resch, A & Rutkowski, S 2014, 'Recent developments and current concepts in medulloblastoma', CANCER TREAT REV, vol. 40, no. 3, pp. 356-365. https://doi.org/10.1016/j.ctrv.2013.11.010

APA

Gerber, N. U., Mynarek, M., von Hoff, K., Friedrich, C., Resch, A., & Rutkowski, S. (2014). Recent developments and current concepts in medulloblastoma. CANCER TREAT REV, 40(3), 356-365. https://doi.org/10.1016/j.ctrv.2013.11.010

Vancouver

Gerber NU, Mynarek M, von Hoff K, Friedrich C, Resch A, Rutkowski S. Recent developments and current concepts in medulloblastoma. CANCER TREAT REV. 2014 Apr 1;40(3):356-365. https://doi.org/10.1016/j.ctrv.2013.11.010

Bibtex

@article{d4ab41edf79a4718a97665300104b74a,

title = "Recent developments and current concepts in medulloblastoma",

abstract = "Medulloblastoma is the most common malignant brain tumor of childhood. While prognosis has significantly improved in the last decades with multimodal therapy including surgery, radiotherapy, and chemotherapy, one third of patients still succumb to their disease. Further research is needed to find more efficient treatment strategies for prognostically unfavorable patient groups and to minimize long-term sequelae of tumor treatment. This review gives a summary of the current state of treatment concepts including an outlook on the near future. We describe recent advances in the understanding of molecular mechanisms, their potential impact on risk stratification in upcoming clinical trials, and perspectives for the clinical implementation of targeted therapies.",

keywords = "Brain Neoplasms, Child, Combined Modality Therapy, Humans, Incidence, Medulloblastoma, Prognosis, World Health",

author = "Gerber, {N U} and M Mynarek and {von Hoff}, K and C Friedrich and A Resch and S Rutkowski",

year = "2014",

month = apr,

day = "1",

doi = "10.1016/j.ctrv.2013.11.010",

language = "English",

volume = "40",

pages = "356--365",

journal = "CANCER TREAT REV",

issn = "0305-7372",

publisher = "W.B. Saunders Ltd",

number = "3",

}

RIS

TY - JOUR

T1 - Recent developments and current concepts in medulloblastoma

AU - Gerber, N U

AU - Mynarek, M

AU - von Hoff, K

AU - Friedrich, C

AU - Resch, A

AU - Rutkowski, S

PY - 2014/4/1

Y1 - 2014/4/1

N2 - Medulloblastoma is the most common malignant brain tumor of childhood. While prognosis has significantly improved in the last decades with multimodal therapy including surgery, radiotherapy, and chemotherapy, one third of patients still succumb to their disease. Further research is needed to find more efficient treatment strategies for prognostically unfavorable patient groups and to minimize long-term sequelae of tumor treatment. This review gives a summary of the current state of treatment concepts including an outlook on the near future. We describe recent advances in the understanding of molecular mechanisms, their potential impact on risk stratification in upcoming clinical trials, and perspectives for the clinical implementation of targeted therapies.

AB - Medulloblastoma is the most common malignant brain tumor of childhood. While prognosis has significantly improved in the last decades with multimodal therapy including surgery, radiotherapy, and chemotherapy, one third of patients still succumb to their disease. Further research is needed to find more efficient treatment strategies for prognostically unfavorable patient groups and to minimize long-term sequelae of tumor treatment. This review gives a summary of the current state of treatment concepts including an outlook on the near future. We describe recent advances in the understanding of molecular mechanisms, their potential impact on risk stratification in upcoming clinical trials, and perspectives for the clinical implementation of targeted therapies.

KW - Brain Neoplasms

KW - Child

KW - Combined Modality Therapy

KW - Humans

KW - Incidence

KW - Medulloblastoma

KW - Prognosis

KW - World Health

U2 - 10.1016/j.ctrv.2013.11.010

DO - 10.1016/j.ctrv.2013.11.010

M3 - SCORING: Journal article

C2 - 24389035

VL - 40

SP - 356

EP - 365

JO - CANCER TREAT REV

JF - CANCER TREAT REV

SN - 0305-7372

IS - 3

ER -