Recent developments and current concepts in medulloblastoma
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Recent developments and current concepts in medulloblastoma. / Gerber, N U; Mynarek, M; von Hoff, K; Friedrich, C; Resch, A; Rutkowski, S.
in: CANCER TREAT REV, Jahrgang 40, Nr. 3, 01.04.2014, S. 356-365.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Recent developments and current concepts in medulloblastoma
AU - Gerber, N U
AU - Mynarek, M
AU - von Hoff, K
AU - Friedrich, C
AU - Resch, A
AU - Rutkowski, S
N1 - Copyright © 2013 Elsevier Ltd. All rights reserved.
PY - 2014/4/1
Y1 - 2014/4/1
N2 - Medulloblastoma is the most common malignant brain tumor of childhood. While prognosis has significantly improved in the last decades with multimodal therapy including surgery, radiotherapy, and chemotherapy, one third of patients still succumb to their disease. Further research is needed to find more efficient treatment strategies for prognostically unfavorable patient groups and to minimize long-term sequelae of tumor treatment. This review gives a summary of the current state of treatment concepts including an outlook on the near future. We describe recent advances in the understanding of molecular mechanisms, their potential impact on risk stratification in upcoming clinical trials, and perspectives for the clinical implementation of targeted therapies.
AB - Medulloblastoma is the most common malignant brain tumor of childhood. While prognosis has significantly improved in the last decades with multimodal therapy including surgery, radiotherapy, and chemotherapy, one third of patients still succumb to their disease. Further research is needed to find more efficient treatment strategies for prognostically unfavorable patient groups and to minimize long-term sequelae of tumor treatment. This review gives a summary of the current state of treatment concepts including an outlook on the near future. We describe recent advances in the understanding of molecular mechanisms, their potential impact on risk stratification in upcoming clinical trials, and perspectives for the clinical implementation of targeted therapies.
KW - Brain Neoplasms
KW - Child
KW - Combined Modality Therapy
KW - Humans
KW - Incidence
KW - Medulloblastoma
KW - Prognosis
KW - World Health
U2 - 10.1016/j.ctrv.2013.11.010
DO - 10.1016/j.ctrv.2013.11.010
M3 - SCORING: Journal article
C2 - 24389035
VL - 40
SP - 356
EP - 365
JO - CANCER TREAT REV
JF - CANCER TREAT REV
SN - 0305-7372
IS - 3
ER -