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Reappearance of effector T cells is associated with recovery from COVID-19

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Reappearance of effector T cells is associated with recovery from COVID-19. / Odak, Ivan; Barros-Martins, Joana; Bošnjak, Berislav; Stahl, Klaus; David, Sascha; Wiesner, Olaf; Busch, Markus; Hoeper, Marius M; Pink, Isabell; Welte, Tobias; Cornberg, Markus; Stoll, Matthias; Goudeva, Lilia; Blasczyk, Rainer; Ganser, Arnold; Prinz, Immo; Förster, Reinhold; Koenecke, Christian; Schultze-Florey, Christian R.

In: EBIOMEDICINE, Vol. 57, 102885, 07.2020.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Odak, I, Barros-Martins, J, Bošnjak, B, Stahl, K, David, S, Wiesner, O, Busch, M, Hoeper, MM, Pink, I, Welte, T, Cornberg, M, Stoll, M, Goudeva, L, Blasczyk, R, Ganser, A, Prinz, I, Förster, R, Koenecke, C & Schultze-Florey, CR 2020, 'Reappearance of effector T cells is associated with recovery from COVID-19', EBIOMEDICINE, vol. 57, 102885. https://doi.org/10.1016/j.ebiom.2020.102885

APA

Odak, I., Barros-Martins, J., Bošnjak, B., Stahl, K., David, S., Wiesner, O., Busch, M., Hoeper, M. M., Pink, I., Welte, T., Cornberg, M., Stoll, M., Goudeva, L., Blasczyk, R., Ganser, A., Prinz, I., Förster, R., Koenecke, C., & Schultze-Florey, C. R. (2020). Reappearance of effector T cells is associated with recovery from COVID-19. EBIOMEDICINE, 57, [102885]. https://doi.org/10.1016/j.ebiom.2020.102885

Vancouver

Odak I, Barros-Martins J, Bošnjak B, Stahl K, David S, Wiesner O et al. Reappearance of effector T cells is associated with recovery from COVID-19. EBIOMEDICINE. 2020 Jul;57. 102885. https://doi.org/10.1016/j.ebiom.2020.102885

Bibtex

@article{0623a0f4933045f699cc8a2eb3904f0b,
title = "Reappearance of effector T cells is associated with recovery from COVID-19",
abstract = "BACKGROUND: Elucidating the role of T cell responses in COVID-19 is of utmost importance to understand the clearance of SARS-CoV-2 infection.METHODS: 30 hospitalized COVID-19 patients and 60 age- and gender-matched healthy controls (HC) participated in this study. We used two comprehensive 11-colour flow cytometric panels conforming to Good Laboratory Practice and approved for clinical diagnostics.FINDINGS: Absolute numbers of lymphocyte subsets were differentially decreased in COVID-19 patients according to clinical severity. In severe disease (SD) patients, all lymphocyte subsets were reduced, whilst in mild disease (MD) NK, NKT and γδ T cells were at the level of HC. Additionally, we provide evidence of T cell activation in MD but not SD, when compared to HC. Follow up samples revealed a marked increase in effector T cells and memory subsets in convalescing but not in non-convalescing patients.INTERPRETATION: Our data suggest that activation and expansion of innate and adaptive lymphocytes play a major role in COVID-19. Additionally, recovery is associated with formation of T cell memory as suggested by the missing formation of effector and central memory T cells in SD but not in MD. Understanding T cell-responses in the context of clinical severity might serve as foundation to overcome the lack of effective anti-viral immune response in severely affected COVID-19 patients and can offer prognostic value as biomarker for disease outcome and control.FUNDING: Funded by State of Lower Saxony grant 14-76,103-184CORONA-11/20 and German Research Foundation, Excellence Strategy - EXC2155{"}RESIST{"}-Project ID39087428, and DFG-SFB900/3-Project ID158989968, grants SFB900-B3, SFB900-B8.",
keywords = "Adult, Aged, Aged, 80 and over, Betacoronavirus/immunology, Biomarkers, CD4-Positive T-Lymphocytes/cytology, CD8-Positive T-Lymphocytes/cytology, COVID-19, Coronavirus Infections/immunology, Female, Humans, Immunologic Memory/immunology, Lymphocyte Activation/immunology, Lymphocyte Count, Male, Middle Aged, Pandemics, Pneumonia, Viral/immunology, Prognosis, SARS-CoV-2, Severity of Illness Index, Young Adult",
author = "Ivan Odak and Joana Barros-Martins and Berislav Bo{\v s}njak and Klaus Stahl and Sascha David and Olaf Wiesner and Markus Busch and Hoeper, {Marius M} and Isabell Pink and Tobias Welte and Markus Cornberg and Matthias Stoll and Lilia Goudeva and Rainer Blasczyk and Arnold Ganser and Immo Prinz and Reinhold F{\"o}rster and Christian Koenecke and Schultze-Florey, {Christian R}",
note = "Copyright {\textcopyright} 2020 The Authors. Published by Elsevier B.V. All rights reserved.",
year = "2020",
month = jul,
doi = "10.1016/j.ebiom.2020.102885",
language = "English",
volume = "57",
journal = "EBIOMEDICINE",
issn = "2352-3964",
publisher = "Elsevier BV",

}

RIS

TY - JOUR

T1 - Reappearance of effector T cells is associated with recovery from COVID-19

AU - Odak, Ivan

AU - Barros-Martins, Joana

AU - Bošnjak, Berislav

AU - Stahl, Klaus

AU - David, Sascha

AU - Wiesner, Olaf

AU - Busch, Markus

AU - Hoeper, Marius M

AU - Pink, Isabell

AU - Welte, Tobias

AU - Cornberg, Markus

AU - Stoll, Matthias

AU - Goudeva, Lilia

AU - Blasczyk, Rainer

AU - Ganser, Arnold

AU - Prinz, Immo

AU - Förster, Reinhold

AU - Koenecke, Christian

AU - Schultze-Florey, Christian R

N1 - Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.

PY - 2020/7

Y1 - 2020/7

N2 - BACKGROUND: Elucidating the role of T cell responses in COVID-19 is of utmost importance to understand the clearance of SARS-CoV-2 infection.METHODS: 30 hospitalized COVID-19 patients and 60 age- and gender-matched healthy controls (HC) participated in this study. We used two comprehensive 11-colour flow cytometric panels conforming to Good Laboratory Practice and approved for clinical diagnostics.FINDINGS: Absolute numbers of lymphocyte subsets were differentially decreased in COVID-19 patients according to clinical severity. In severe disease (SD) patients, all lymphocyte subsets were reduced, whilst in mild disease (MD) NK, NKT and γδ T cells were at the level of HC. Additionally, we provide evidence of T cell activation in MD but not SD, when compared to HC. Follow up samples revealed a marked increase in effector T cells and memory subsets in convalescing but not in non-convalescing patients.INTERPRETATION: Our data suggest that activation and expansion of innate and adaptive lymphocytes play a major role in COVID-19. Additionally, recovery is associated with formation of T cell memory as suggested by the missing formation of effector and central memory T cells in SD but not in MD. Understanding T cell-responses in the context of clinical severity might serve as foundation to overcome the lack of effective anti-viral immune response in severely affected COVID-19 patients and can offer prognostic value as biomarker for disease outcome and control.FUNDING: Funded by State of Lower Saxony grant 14-76,103-184CORONA-11/20 and German Research Foundation, Excellence Strategy - EXC2155"RESIST"-Project ID39087428, and DFG-SFB900/3-Project ID158989968, grants SFB900-B3, SFB900-B8.

AB - BACKGROUND: Elucidating the role of T cell responses in COVID-19 is of utmost importance to understand the clearance of SARS-CoV-2 infection.METHODS: 30 hospitalized COVID-19 patients and 60 age- and gender-matched healthy controls (HC) participated in this study. We used two comprehensive 11-colour flow cytometric panels conforming to Good Laboratory Practice and approved for clinical diagnostics.FINDINGS: Absolute numbers of lymphocyte subsets were differentially decreased in COVID-19 patients according to clinical severity. In severe disease (SD) patients, all lymphocyte subsets were reduced, whilst in mild disease (MD) NK, NKT and γδ T cells were at the level of HC. Additionally, we provide evidence of T cell activation in MD but not SD, when compared to HC. Follow up samples revealed a marked increase in effector T cells and memory subsets in convalescing but not in non-convalescing patients.INTERPRETATION: Our data suggest that activation and expansion of innate and adaptive lymphocytes play a major role in COVID-19. Additionally, recovery is associated with formation of T cell memory as suggested by the missing formation of effector and central memory T cells in SD but not in MD. Understanding T cell-responses in the context of clinical severity might serve as foundation to overcome the lack of effective anti-viral immune response in severely affected COVID-19 patients and can offer prognostic value as biomarker for disease outcome and control.FUNDING: Funded by State of Lower Saxony grant 14-76,103-184CORONA-11/20 and German Research Foundation, Excellence Strategy - EXC2155"RESIST"-Project ID39087428, and DFG-SFB900/3-Project ID158989968, grants SFB900-B3, SFB900-B8.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Betacoronavirus/immunology

KW - Biomarkers

KW - CD4-Positive T-Lymphocytes/cytology

KW - CD8-Positive T-Lymphocytes/cytology

KW - COVID-19

KW - Coronavirus Infections/immunology

KW - Female

KW - Humans

KW - Immunologic Memory/immunology

KW - Lymphocyte Activation/immunology

KW - Lymphocyte Count

KW - Male

KW - Middle Aged

KW - Pandemics

KW - Pneumonia, Viral/immunology

KW - Prognosis

KW - SARS-CoV-2

KW - Severity of Illness Index

KW - Young Adult

U2 - 10.1016/j.ebiom.2020.102885

DO - 10.1016/j.ebiom.2020.102885

M3 - SCORING: Journal article

C2 - 32650275

VL - 57

JO - EBIOMEDICINE

JF - EBIOMEDICINE

SN - 2352-3964

M1 - 102885

ER -