Real-time magnetic resonance imaging and quantification of lipoprotein metabolism in vivo using nanocrystals.

Oliver Bruns; Harald Ittrich; Kersten Peldschus; Michael Kaul; Ulrich I Tromsdorf; Joachim Lauterwasser; Marija S Nikolic; Birgit Mollwitz; Martin Merkel; Nadja C Bigall; Sameer Sapra; Rudolph Reimer; Heinz Hohenberg; Horst Weller; Alexander Eychmüller; Gerhard Adam; Ulrike Beisiegel; Jörg Heeren

Real-time magnetic resonance imaging and quantification of lipoprotein metabolism in vivo using nanocrystals.

Standard

Real-time magnetic resonance imaging and quantification of lipoprotein metabolism in vivo using nanocrystals. / Bruns, Oliver; Ittrich, Harald; Peldschus, Kersten ; Kaul, Michael; Tromsdorf, Ulrich I; Lauterwasser, Joachim; Nikolic, Marija S; Mollwitz, Birgit; Merkel, Martin; Bigall, Nadja C; Sapra, Sameer; Reimer, Rudolph; Hohenberg, Heinz; Weller, Horst; Eychmüller, Alexander; Adam, Gerhard; Beisiegel, Ulrike; Heeren, Jörg.

In: NAT NANOTECHNOL, Vol. 4, No. 3, 3, 2009, p. 193-201.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Bruns, O, Ittrich, H, Peldschus, K , Kaul, M, Tromsdorf, UI, Lauterwasser, J, Nikolic, MS, Mollwitz, B, Merkel, M, Bigall, NC, Sapra, S, Reimer, R, Hohenberg, H, Weller, H, Eychmüller, A, Adam, G, Beisiegel, U & Heeren, J 2009, 'Real-time magnetic resonance imaging and quantification of lipoprotein metabolism in vivo using nanocrystals.', NAT NANOTECHNOL, vol. 4, no. 3, 3, pp. 193-201. <http://www.ncbi.nlm.nih.gov/pubmed/19265850?dopt=Citation>

APA

Bruns, O., Ittrich, H., Peldschus, K., Kaul, M., Tromsdorf, U. I., Lauterwasser, J., Nikolic, M. S., Mollwitz, B., Merkel, M., Bigall, N. C., Sapra, S., Reimer, R., Hohenberg, H., Weller, H., Eychmüller, A., Adam, G., Beisiegel, U., & Heeren, J. (2009). Real-time magnetic resonance imaging and quantification of lipoprotein metabolism in vivo using nanocrystals. NAT NANOTECHNOL, 4(3), 193-201. [3]. http://www.ncbi.nlm.nih.gov/pubmed/19265850?dopt=Citation

Vancouver

Bruns O, Ittrich H, Peldschus K , Kaul M, Tromsdorf UI, Lauterwasser J et al. Real-time magnetic resonance imaging and quantification of lipoprotein metabolism in vivo using nanocrystals. NAT NANOTECHNOL. 2009;4(3):193-201. 3.

Bibtex

@article{3352e6ada1bc456d9dd79c469001a783,

title = "Real-time magnetic resonance imaging and quantification of lipoprotein metabolism in vivo using nanocrystals.",

abstract = "Semiconductor quantum dots and superparamagnetic iron oxide nanocrystals have physical properties that are well suited for biomedical imaging. Previously, we have shown that iron oxide nanocrystals embedded within the lipid core of micelles show optimized characteristics for quantitative imaging. Here, we embed quantum dots and superparamagnetic iron oxide nanocrystals in the core of lipoproteins--micelles that transport lipids and other hydrophobic substances in the blood--and show that it is possible to image and quantify the kinetics of lipoprotein metabolism in vivo using fluorescence and dynamic magnetic resonance imaging. The lipoproteins were taken up by liver cells in wild-type mice and displayed defective clearance in knock-out mice lacking a lipoprotein receptor or its ligand, indicating that the nanocrystals did not influence the specificity of the metabolic process. Using this strategy it is possible to study the clearance of lipoproteins in metabolic disorders and to improve the contrast in clinical imaging.",

author = "Oliver Bruns and Harald Ittrich and Kersten Peldschus and Michael Kaul and Tromsdorf, {Ulrich I} and Joachim Lauterwasser and Nikolic, {Marija S} and Birgit Mollwitz and Martin Merkel and Bigall, {Nadja C} and Sameer Sapra and Rudolph Reimer and Heinz Hohenberg and Horst Weller and Alexander Eychm{\"u}ller and Gerhard Adam and Ulrike Beisiegel and J{\"o}rg Heeren",

year = "2009",

language = "Deutsch",

volume = "4",

pages = "193--201",

number = "3",

}

RIS

TY - JOUR

T1 - Real-time magnetic resonance imaging and quantification of lipoprotein metabolism in vivo using nanocrystals.

AU - Bruns, Oliver

AU - Ittrich, Harald

AU - Peldschus, Kersten

AU - Kaul, Michael

AU - Tromsdorf, Ulrich I

AU - Lauterwasser, Joachim

AU - Nikolic, Marija S

AU - Mollwitz, Birgit

AU - Merkel, Martin

AU - Bigall, Nadja C

AU - Sapra, Sameer

AU - Reimer, Rudolph

AU - Hohenberg, Heinz

AU - Weller, Horst

AU - Eychmüller, Alexander

AU - Adam, Gerhard

AU - Beisiegel, Ulrike

AU - Heeren, Jörg

PY - 2009

Y1 - 2009

N2 - Semiconductor quantum dots and superparamagnetic iron oxide nanocrystals have physical properties that are well suited for biomedical imaging. Previously, we have shown that iron oxide nanocrystals embedded within the lipid core of micelles show optimized characteristics for quantitative imaging. Here, we embed quantum dots and superparamagnetic iron oxide nanocrystals in the core of lipoproteins--micelles that transport lipids and other hydrophobic substances in the blood--and show that it is possible to image and quantify the kinetics of lipoprotein metabolism in vivo using fluorescence and dynamic magnetic resonance imaging. The lipoproteins were taken up by liver cells in wild-type mice and displayed defective clearance in knock-out mice lacking a lipoprotein receptor or its ligand, indicating that the nanocrystals did not influence the specificity of the metabolic process. Using this strategy it is possible to study the clearance of lipoproteins in metabolic disorders and to improve the contrast in clinical imaging.

AB - Semiconductor quantum dots and superparamagnetic iron oxide nanocrystals have physical properties that are well suited for biomedical imaging. Previously, we have shown that iron oxide nanocrystals embedded within the lipid core of micelles show optimized characteristics for quantitative imaging. Here, we embed quantum dots and superparamagnetic iron oxide nanocrystals in the core of lipoproteins--micelles that transport lipids and other hydrophobic substances in the blood--and show that it is possible to image and quantify the kinetics of lipoprotein metabolism in vivo using fluorescence and dynamic magnetic resonance imaging. The lipoproteins were taken up by liver cells in wild-type mice and displayed defective clearance in knock-out mice lacking a lipoprotein receptor or its ligand, indicating that the nanocrystals did not influence the specificity of the metabolic process. Using this strategy it is possible to study the clearance of lipoproteins in metabolic disorders and to improve the contrast in clinical imaging.

M3 - SCORING: Zeitschriftenaufsatz

VL - 4

SP - 193

EP - 201

IS - 3

M1 - 3

ER -