Real-time magnetic resonance imaging and quantification of lipoprotein metabolism in vivo using nanocrystals.
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Real-time magnetic resonance imaging and quantification of lipoprotein metabolism in vivo using nanocrystals. / Bruns, Oliver; Ittrich, Harald; Peldschus, Kersten; Kaul, Michael; Tromsdorf, Ulrich I; Lauterwasser, Joachim; Nikolic, Marija S; Mollwitz, Birgit; Merkel, Martin; Bigall, Nadja C; Sapra, Sameer; Reimer, Rudolph; Hohenberg, Heinz; Weller, Horst; Eychmüller, Alexander; Adam, Gerhard; Beisiegel, Ulrike; Heeren, Jörg.
in: NAT NANOTECHNOL, Jahrgang 4, Nr. 3, 3, 2009, S. 193-201.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Real-time magnetic resonance imaging and quantification of lipoprotein metabolism in vivo using nanocrystals.
AU - Bruns, Oliver
AU - Ittrich, Harald
AU - Peldschus, Kersten
AU - Kaul, Michael
AU - Tromsdorf, Ulrich I
AU - Lauterwasser, Joachim
AU - Nikolic, Marija S
AU - Mollwitz, Birgit
AU - Merkel, Martin
AU - Bigall, Nadja C
AU - Sapra, Sameer
AU - Reimer, Rudolph
AU - Hohenberg, Heinz
AU - Weller, Horst
AU - Eychmüller, Alexander
AU - Adam, Gerhard
AU - Beisiegel, Ulrike
AU - Heeren, Jörg
PY - 2009
Y1 - 2009
N2 - Semiconductor quantum dots and superparamagnetic iron oxide nanocrystals have physical properties that are well suited for biomedical imaging. Previously, we have shown that iron oxide nanocrystals embedded within the lipid core of micelles show optimized characteristics for quantitative imaging. Here, we embed quantum dots and superparamagnetic iron oxide nanocrystals in the core of lipoproteins--micelles that transport lipids and other hydrophobic substances in the blood--and show that it is possible to image and quantify the kinetics of lipoprotein metabolism in vivo using fluorescence and dynamic magnetic resonance imaging. The lipoproteins were taken up by liver cells in wild-type mice and displayed defective clearance in knock-out mice lacking a lipoprotein receptor or its ligand, indicating that the nanocrystals did not influence the specificity of the metabolic process. Using this strategy it is possible to study the clearance of lipoproteins in metabolic disorders and to improve the contrast in clinical imaging.
AB - Semiconductor quantum dots and superparamagnetic iron oxide nanocrystals have physical properties that are well suited for biomedical imaging. Previously, we have shown that iron oxide nanocrystals embedded within the lipid core of micelles show optimized characteristics for quantitative imaging. Here, we embed quantum dots and superparamagnetic iron oxide nanocrystals in the core of lipoproteins--micelles that transport lipids and other hydrophobic substances in the blood--and show that it is possible to image and quantify the kinetics of lipoprotein metabolism in vivo using fluorescence and dynamic magnetic resonance imaging. The lipoproteins were taken up by liver cells in wild-type mice and displayed defective clearance in knock-out mice lacking a lipoprotein receptor or its ligand, indicating that the nanocrystals did not influence the specificity of the metabolic process. Using this strategy it is possible to study the clearance of lipoproteins in metabolic disorders and to improve the contrast in clinical imaging.
M3 - SCORING: Zeitschriftenaufsatz
VL - 4
SP - 193
EP - 201
IS - 3
M1 - 3
ER -