Radiotherapy of the R1H-tumor: dose-rate effect on tumor response in brachytherapy with 106-ruthenium eye applicators.
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Radiotherapy of the R1H-tumor: dose-rate effect on tumor response in brachytherapy with 106-ruthenium eye applicators. / Kleineidam, M; Guthoff, R; Schiller, F; Chumbley, L; Beck-Bornholdt, Hans-Peter.
In: INT J RADIAT ONCOL, Vol. 25, No. 2, 2, 1993, p. 277-281.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Radiotherapy of the R1H-tumor: dose-rate effect on tumor response in brachytherapy with 106-ruthenium eye applicators.
AU - Kleineidam, M
AU - Guthoff, R
AU - Schiller, F
AU - Chumbley, L
AU - Beck-Bornholdt, Hans-Peter
PY - 1993
Y1 - 1993
N2 - PURPOSE: The influence of the dose-rate on tumor response in radiotherapy with 106-Ruthenium eye plaques has been investigated in an experimental tumor system. MATERIALS AND METHODS: The identical total dose was applied within three different overall treatment times (42 hr, 192 hr and 312 hr), corresponding to dose-rates of 6.0 Gy/hr, 1.3 Gy/hr and 0.8 Gy/hr. RESULTS: The therapeutic outcome of brachytherapy varied significantly between the three groups of animals treated with different dose-rates. At a dose-rate of 1.3 Gy/hr all tumors were locally controlled, but no local control was observed when a dose-rate of 6.0 Gy/hr was delivered. 0.8 Gy/hr was less effective than 1.3 Gy/hr but more effective than 6.0 Gy/hr. CONCLUSION: These results were unexpected but they might be explained by an incomplete reoxygenation if the overall treatment time is too short (42 hr, dose-rate 6.0 Gy/hr) and by proliferation of tumor cells under treatment if the overall treatment time is too long (312 hr, 0.8 Gy/hr).
AB - PURPOSE: The influence of the dose-rate on tumor response in radiotherapy with 106-Ruthenium eye plaques has been investigated in an experimental tumor system. MATERIALS AND METHODS: The identical total dose was applied within three different overall treatment times (42 hr, 192 hr and 312 hr), corresponding to dose-rates of 6.0 Gy/hr, 1.3 Gy/hr and 0.8 Gy/hr. RESULTS: The therapeutic outcome of brachytherapy varied significantly between the three groups of animals treated with different dose-rates. At a dose-rate of 1.3 Gy/hr all tumors were locally controlled, but no local control was observed when a dose-rate of 6.0 Gy/hr was delivered. 0.8 Gy/hr was less effective than 1.3 Gy/hr but more effective than 6.0 Gy/hr. CONCLUSION: These results were unexpected but they might be explained by an incomplete reoxygenation if the overall treatment time is too short (42 hr, dose-rate 6.0 Gy/hr) and by proliferation of tumor cells under treatment if the overall treatment time is too long (312 hr, 0.8 Gy/hr).
M3 - SCORING: Zeitschriftenaufsatz
VL - 25
SP - 277
EP - 281
JO - INT J RADIAT ONCOL
JF - INT J RADIAT ONCOL
SN - 0360-3016
IS - 2
M1 - 2
ER -