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Radiotherapy of the R1H-tumor: dose-rate effect on tumor response in brachytherapy with 106-ruthenium eye applicators.

Standard

Radiotherapy of the R1H-tumor: dose-rate effect on tumor response in brachytherapy with 106-ruthenium eye applicators. / Kleineidam, M; Guthoff, R; Schiller, F; Chumbley, L; Beck-Bornholdt, Hans-Peter.

in: INT J RADIAT ONCOL, Jahrgang 25, Nr. 2, 2, 1993, S. 277-281.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Kleineidam, M, Guthoff, R, Schiller, F, Chumbley, L & Beck-Bornholdt, H-P 1993, 'Radiotherapy of the R1H-tumor: dose-rate effect on tumor response in brachytherapy with 106-ruthenium eye applicators.', INT J RADIAT ONCOL, Jg. 25, Nr. 2, 2, S. 277-281. <http://www.ncbi.nlm.nih.gov/pubmed/8420875?dopt=Citation>

APA

Kleineidam, M., Guthoff, R., Schiller, F., Chumbley, L., & Beck-Bornholdt, H-P. (1993). Radiotherapy of the R1H-tumor: dose-rate effect on tumor response in brachytherapy with 106-ruthenium eye applicators. INT J RADIAT ONCOL, 25(2), 277-281. [2]. http://www.ncbi.nlm.nih.gov/pubmed/8420875?dopt=Citation

Vancouver

Kleineidam M, Guthoff R, Schiller F, Chumbley L, Beck-Bornholdt H-P. Radiotherapy of the R1H-tumor: dose-rate effect on tumor response in brachytherapy with 106-ruthenium eye applicators. INT J RADIAT ONCOL. 1993;25(2):277-281. 2.

Bibtex

@article{d4ecb9b1143e496bb2fe8aac4f2aede2,
title = "Radiotherapy of the R1H-tumor: dose-rate effect on tumor response in brachytherapy with 106-ruthenium eye applicators.",
abstract = "PURPOSE: The influence of the dose-rate on tumor response in radiotherapy with 106-Ruthenium eye plaques has been investigated in an experimental tumor system. MATERIALS AND METHODS: The identical total dose was applied within three different overall treatment times (42 hr, 192 hr and 312 hr), corresponding to dose-rates of 6.0 Gy/hr, 1.3 Gy/hr and 0.8 Gy/hr. RESULTS: The therapeutic outcome of brachytherapy varied significantly between the three groups of animals treated with different dose-rates. At a dose-rate of 1.3 Gy/hr all tumors were locally controlled, but no local control was observed when a dose-rate of 6.0 Gy/hr was delivered. 0.8 Gy/hr was less effective than 1.3 Gy/hr but more effective than 6.0 Gy/hr. CONCLUSION: These results were unexpected but they might be explained by an incomplete reoxygenation if the overall treatment time is too short (42 hr, dose-rate 6.0 Gy/hr) and by proliferation of tumor cells under treatment if the overall treatment time is too long (312 hr, 0.8 Gy/hr).",
author = "M Kleineidam and R Guthoff and F Schiller and L Chumbley and Hans-Peter Beck-Bornholdt",
year = "1993",
language = "Deutsch",
volume = "25",
pages = "277--281",
journal = "INT J RADIAT ONCOL",
issn = "0360-3016",
publisher = "Elsevier Inc.",
number = "2",

}

RIS

TY - JOUR

T1 - Radiotherapy of the R1H-tumor: dose-rate effect on tumor response in brachytherapy with 106-ruthenium eye applicators.

AU - Kleineidam, M

AU - Guthoff, R

AU - Schiller, F

AU - Chumbley, L

AU - Beck-Bornholdt, Hans-Peter

PY - 1993

Y1 - 1993

N2 - PURPOSE: The influence of the dose-rate on tumor response in radiotherapy with 106-Ruthenium eye plaques has been investigated in an experimental tumor system. MATERIALS AND METHODS: The identical total dose was applied within three different overall treatment times (42 hr, 192 hr and 312 hr), corresponding to dose-rates of 6.0 Gy/hr, 1.3 Gy/hr and 0.8 Gy/hr. RESULTS: The therapeutic outcome of brachytherapy varied significantly between the three groups of animals treated with different dose-rates. At a dose-rate of 1.3 Gy/hr all tumors were locally controlled, but no local control was observed when a dose-rate of 6.0 Gy/hr was delivered. 0.8 Gy/hr was less effective than 1.3 Gy/hr but more effective than 6.0 Gy/hr. CONCLUSION: These results were unexpected but they might be explained by an incomplete reoxygenation if the overall treatment time is too short (42 hr, dose-rate 6.0 Gy/hr) and by proliferation of tumor cells under treatment if the overall treatment time is too long (312 hr, 0.8 Gy/hr).

AB - PURPOSE: The influence of the dose-rate on tumor response in radiotherapy with 106-Ruthenium eye plaques has been investigated in an experimental tumor system. MATERIALS AND METHODS: The identical total dose was applied within three different overall treatment times (42 hr, 192 hr and 312 hr), corresponding to dose-rates of 6.0 Gy/hr, 1.3 Gy/hr and 0.8 Gy/hr. RESULTS: The therapeutic outcome of brachytherapy varied significantly between the three groups of animals treated with different dose-rates. At a dose-rate of 1.3 Gy/hr all tumors were locally controlled, but no local control was observed when a dose-rate of 6.0 Gy/hr was delivered. 0.8 Gy/hr was less effective than 1.3 Gy/hr but more effective than 6.0 Gy/hr. CONCLUSION: These results were unexpected but they might be explained by an incomplete reoxygenation if the overall treatment time is too short (42 hr, dose-rate 6.0 Gy/hr) and by proliferation of tumor cells under treatment if the overall treatment time is too long (312 hr, 0.8 Gy/hr).

M3 - SCORING: Zeitschriftenaufsatz

VL - 25

SP - 277

EP - 281

JO - INT J RADIAT ONCOL

JF - INT J RADIAT ONCOL

SN - 0360-3016

IS - 2

M1 - 2

ER -