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Radiosurgery with 20 Gy provides better local contol of 1-3 brain metastases from breast cancer than with lower doses.

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Radiosurgery with 20 Gy provides better local contol of 1-3 brain metastases from breast cancer than with lower doses. / Rades, Dirk; Huttenlocher, Stefan; Rudat, Volker; Hornung, Dagmar; Blanck, Oliver; Phuong, Pham Cam; Khoa, Mai Trong; Schild, Steven E.; Fischer, Dorothea.

In: ANTICANCER RES, Vol. 35, No. 1, 01.01.2015, p. 333-336.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Rades, D, Huttenlocher, S, Rudat, V, Hornung, D, Blanck, O, Phuong, PC, Khoa, MT, Schild, SE & Fischer, D 2015, 'Radiosurgery with 20 Gy provides better local contol of 1-3 brain metastases from breast cancer than with lower doses.', ANTICANCER RES, vol. 35, no. 1, pp. 333-336.

APA

Rades, D., Huttenlocher, S., Rudat, V., Hornung, D., Blanck, O., Phuong, P. C., Khoa, M. T., Schild, S. E., & Fischer, D. (2015). Radiosurgery with 20 Gy provides better local contol of 1-3 brain metastases from breast cancer than with lower doses. ANTICANCER RES, 35(1), 333-336.

Vancouver

Rades D, Huttenlocher S, Rudat V, Hornung D, Blanck O, Phuong PC et al. Radiosurgery with 20 Gy provides better local contol of 1-3 brain metastases from breast cancer than with lower doses. ANTICANCER RES. 2015 Jan 1;35(1):333-336.

Bibtex

@article{8eea83b072a347b8bccf2d7fc19e7a8f,
title = "Radiosurgery with 20 Gy provides better local contol of 1-3 brain metastases from breast cancer than with lower doses.",
abstract = "To determine the optimal dose of radiosurgery-alone for patients with 1-3 cerebral metastases from breast cancer.Patients receiving 20 Gy (n=20) were compared to those receiving 16-18.5 Gy (n=10) for local control, distant brain control and overall survival. Seven other variables were also evaluated.Radiosurgery dose achieved significance on univariate (p=0.002; log-rank and Wilcoxon test) and multivariate analysis (p=0.004) of local control. Twelve-month local control rates were 94% after 20 Gy and 48% after 16-18.5 Gy. On univariate analysis of distant brain control, radiosurgery dose was not a significant factor, with 12-month rates of 73% and 60 respectively. Regarding overall survival, radiosurgery dose was of borderline significance (p=0.059; Wilcoxon test). Twelve-month overall survival rates were 75% and 40 respectively. On Cox regression analysis, radiosurgery dose exhibited a trend for improving survival (p=0.10).Radiosurgery with 20 Gy resulted in significantly better local control and led to a trend towards improved overall survival compared to treatment with 16-18.5 Gy.",
keywords = "Brain Neoplasms, mortality/secondary/surgery, Breast Neoplasms, mortality/pathology/surgery, Female, Humans, Kaplan-Meier Estimate, Middle Aged, Proportional Hazards Models, Radiosurgery, Radiotherapy Dosage, Tumor Burden",
author = "Dirk Rades and Stefan Huttenlocher and Volker Rudat and Dagmar Hornung and Oliver Blanck and Phuong, {Pham Cam} and Khoa, {Mai Trong} and Schild, {Steven E.} and Dorothea Fischer",
year = "2015",
month = jan,
day = "1",
language = "English",
volume = "35",
pages = "333--336",
journal = "ANTICANCER RES",
issn = "0250-7005",
publisher = "International Institute of Anticancer Research",
number = "1",

}

RIS

TY - JOUR

T1 - Radiosurgery with 20 Gy provides better local contol of 1-3 brain metastases from breast cancer than with lower doses.

AU - Rades, Dirk

AU - Huttenlocher, Stefan

AU - Rudat, Volker

AU - Hornung, Dagmar

AU - Blanck, Oliver

AU - Phuong, Pham Cam

AU - Khoa, Mai Trong

AU - Schild, Steven E.

AU - Fischer, Dorothea

PY - 2015/1/1

Y1 - 2015/1/1

N2 - To determine the optimal dose of radiosurgery-alone for patients with 1-3 cerebral metastases from breast cancer.Patients receiving 20 Gy (n=20) were compared to those receiving 16-18.5 Gy (n=10) for local control, distant brain control and overall survival. Seven other variables were also evaluated.Radiosurgery dose achieved significance on univariate (p=0.002; log-rank and Wilcoxon test) and multivariate analysis (p=0.004) of local control. Twelve-month local control rates were 94% after 20 Gy and 48% after 16-18.5 Gy. On univariate analysis of distant brain control, radiosurgery dose was not a significant factor, with 12-month rates of 73% and 60 respectively. Regarding overall survival, radiosurgery dose was of borderline significance (p=0.059; Wilcoxon test). Twelve-month overall survival rates were 75% and 40 respectively. On Cox regression analysis, radiosurgery dose exhibited a trend for improving survival (p=0.10).Radiosurgery with 20 Gy resulted in significantly better local control and led to a trend towards improved overall survival compared to treatment with 16-18.5 Gy.

AB - To determine the optimal dose of radiosurgery-alone for patients with 1-3 cerebral metastases from breast cancer.Patients receiving 20 Gy (n=20) were compared to those receiving 16-18.5 Gy (n=10) for local control, distant brain control and overall survival. Seven other variables were also evaluated.Radiosurgery dose achieved significance on univariate (p=0.002; log-rank and Wilcoxon test) and multivariate analysis (p=0.004) of local control. Twelve-month local control rates were 94% after 20 Gy and 48% after 16-18.5 Gy. On univariate analysis of distant brain control, radiosurgery dose was not a significant factor, with 12-month rates of 73% and 60 respectively. Regarding overall survival, radiosurgery dose was of borderline significance (p=0.059; Wilcoxon test). Twelve-month overall survival rates were 75% and 40 respectively. On Cox regression analysis, radiosurgery dose exhibited a trend for improving survival (p=0.10).Radiosurgery with 20 Gy resulted in significantly better local control and led to a trend towards improved overall survival compared to treatment with 16-18.5 Gy.

KW - Brain Neoplasms, mortality/secondary/surgery

KW - Breast Neoplasms, mortality/pathology/surgery

KW - Female

KW - Humans

KW - Kaplan-Meier Estimate

KW - Middle Aged

KW - Proportional Hazards Models

KW - Radiosurgery

KW - Radiotherapy Dosage

KW - Tumor Burden

M3 - SCORING: Journal article

VL - 35

SP - 333

EP - 336

JO - ANTICANCER RES

JF - ANTICANCER RES

SN - 0250-7005

IS - 1

ER -