Radiosurgery with 20 Gy provides better local contol of 1-3 brain metastases from breast cancer than with lower doses.
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Radiosurgery with 20 Gy provides better local contol of 1-3 brain metastases from breast cancer than with lower doses. / Rades, Dirk; Huttenlocher, Stefan; Rudat, Volker; Hornung, Dagmar; Blanck, Oliver; Phuong, Pham Cam; Khoa, Mai Trong; Schild, Steven E.; Fischer, Dorothea.
in: ANTICANCER RES, Jahrgang 35, Nr. 1, 01.01.2015, S. 333-336.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Radiosurgery with 20 Gy provides better local contol of 1-3 brain metastases from breast cancer than with lower doses.
AU - Rades, Dirk
AU - Huttenlocher, Stefan
AU - Rudat, Volker
AU - Hornung, Dagmar
AU - Blanck, Oliver
AU - Phuong, Pham Cam
AU - Khoa, Mai Trong
AU - Schild, Steven E.
AU - Fischer, Dorothea
PY - 2015/1/1
Y1 - 2015/1/1
N2 - To determine the optimal dose of radiosurgery-alone for patients with 1-3 cerebral metastases from breast cancer.Patients receiving 20 Gy (n=20) were compared to those receiving 16-18.5 Gy (n=10) for local control, distant brain control and overall survival. Seven other variables were also evaluated.Radiosurgery dose achieved significance on univariate (p=0.002; log-rank and Wilcoxon test) and multivariate analysis (p=0.004) of local control. Twelve-month local control rates were 94% after 20 Gy and 48% after 16-18.5 Gy. On univariate analysis of distant brain control, radiosurgery dose was not a significant factor, with 12-month rates of 73% and 60 respectively. Regarding overall survival, radiosurgery dose was of borderline significance (p=0.059; Wilcoxon test). Twelve-month overall survival rates were 75% and 40 respectively. On Cox regression analysis, radiosurgery dose exhibited a trend for improving survival (p=0.10).Radiosurgery with 20 Gy resulted in significantly better local control and led to a trend towards improved overall survival compared to treatment with 16-18.5 Gy.
AB - To determine the optimal dose of radiosurgery-alone for patients with 1-3 cerebral metastases from breast cancer.Patients receiving 20 Gy (n=20) were compared to those receiving 16-18.5 Gy (n=10) for local control, distant brain control and overall survival. Seven other variables were also evaluated.Radiosurgery dose achieved significance on univariate (p=0.002; log-rank and Wilcoxon test) and multivariate analysis (p=0.004) of local control. Twelve-month local control rates were 94% after 20 Gy and 48% after 16-18.5 Gy. On univariate analysis of distant brain control, radiosurgery dose was not a significant factor, with 12-month rates of 73% and 60 respectively. Regarding overall survival, radiosurgery dose was of borderline significance (p=0.059; Wilcoxon test). Twelve-month overall survival rates were 75% and 40 respectively. On Cox regression analysis, radiosurgery dose exhibited a trend for improving survival (p=0.10).Radiosurgery with 20 Gy resulted in significantly better local control and led to a trend towards improved overall survival compared to treatment with 16-18.5 Gy.
KW - Brain Neoplasms, mortality/secondary/surgery
KW - Breast Neoplasms, mortality/pathology/surgery
KW - Female
KW - Humans
KW - Kaplan-Meier Estimate
KW - Middle Aged
KW - Proportional Hazards Models
KW - Radiosurgery
KW - Radiotherapy Dosage
KW - Tumor Burden
M3 - SCORING: Journal article
VL - 35
SP - 333
EP - 336
JO - ANTICANCER RES
JF - ANTICANCER RES
SN - 0250-7005
IS - 1
ER -