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Radiobiological hypoxia, oxygen tension, interstitial fluid pressure and relative viable tumour area in two human squamous cell carcinomas in nude mice during fractionated radiotherapy

Standard

Radiobiological hypoxia, oxygen tension, interstitial fluid pressure and relative viable tumour area in two human squamous cell carcinomas in nude mice during fractionated radiotherapy. / Baumann, M; Appold, S; Zimmer, J; Scharf, M; Beuthien-Baumann, B; Dubben, H H; Enghardt, W; Schreiber, A; Eicheler, W; Petersen, C.

In: ACTA ONCOL, Vol. 40, No. 4, 01.01.2001, p. 519-28.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Baumann, M, Appold, S, Zimmer, J, Scharf, M, Beuthien-Baumann, B, Dubben, HH, Enghardt, W, Schreiber, A, Eicheler, W & Petersen, C 2001, 'Radiobiological hypoxia, oxygen tension, interstitial fluid pressure and relative viable tumour area in two human squamous cell carcinomas in nude mice during fractionated radiotherapy', ACTA ONCOL, vol. 40, no. 4, pp. 519-28.

APA

Baumann, M., Appold, S., Zimmer, J., Scharf, M., Beuthien-Baumann, B., Dubben, H. H., Enghardt, W., Schreiber, A., Eicheler, W., & Petersen, C. (2001). Radiobiological hypoxia, oxygen tension, interstitial fluid pressure and relative viable tumour area in two human squamous cell carcinomas in nude mice during fractionated radiotherapy. ACTA ONCOL, 40(4), 519-28.

Vancouver

Baumann M, Appold S, Zimmer J, Scharf M, Beuthien-Baumann B, Dubben HH et al. Radiobiological hypoxia, oxygen tension, interstitial fluid pressure and relative viable tumour area in two human squamous cell carcinomas in nude mice during fractionated radiotherapy. ACTA ONCOL. 2001 Jan 1;40(4):519-28.

Bibtex

@article{b1780e57228e4b668a3cad3af99ce210,
title = "Radiobiological hypoxia, oxygen tension, interstitial fluid pressure and relative viable tumour area in two human squamous cell carcinomas in nude mice during fractionated radiotherapy",
abstract = "Very little is known about the correlation between the radiobiological hypoxic fraction (rHF) and other measures of tumour oxygenation during fractionated irradiation. In the present study the rHF is determined in untreated human FaDu and GL squamous cell carcinoma in nude mice and in tumours irradiated with 10 fractions in 2 weeks and 20 fractions in 4 weeks, using tumour control as the experimental endpoint. The results were compared with measurements of the pO2, the interstitial fluid pressure (IFP) and the relative viable tumour area. In FaDu tumours the radiobiological hypoxic fractions (rHFs) before and during irradiation were not statistically different from 100%. Depending on the assumptions made for D0, the rHFs of GL tumours were between 0.2 and 4% or 30 and 53%. The median pO2 values were 2.8 mmHg for untreated FaDu tumours and 0.2 mmHg for GL tumours (p < 0.001). The median IFP values were 2.6 mmHg in FaDu and 5.3 mmHg in GL tumours (p = 0.01). No important changes in the pO2 and IFP values were observed during fractionated irradiation. The relative viable tumour area during irradiation decreased by 83% in FaDu tumours (p = 0.002) and by 54% in GL tumours (p = 0.003). It is concluded that differences in rHF exist between FaDu and GL tumours before and during fractionated irradiation and that these differences are not reflected by pO2 and IFP values and the relative viable tumour area.",
keywords = "Animals, Body Fluids, Carcinoma, Squamous Cell, Cell Hypoxia, Cell Survival, Dose Fractionation, Female, Humans, Hypopharyngeal Neoplasms, Immunosuppression, Laryngeal Neoplasms, Male, Mice, Oxygen, Oxygen Consumption, Partial Pressure, Pressure, Radiation Tolerance, Specific Pathogen-Free Organisms, Tumor Cells, Cultured, Whole-Body Irradiation, Xenograft Model Antitumor Assays",
author = "M Baumann and S Appold and J Zimmer and M Scharf and B Beuthien-Baumann and Dubben, {H H} and W Enghardt and A Schreiber and W Eicheler and C Petersen",
year = "2001",
month = jan,
day = "1",
language = "English",
volume = "40",
pages = "519--28",
journal = "ACTA ONCOL",
issn = "0284-186X",
publisher = "informa healthcare",
number = "4",

}

RIS

TY - JOUR

T1 - Radiobiological hypoxia, oxygen tension, interstitial fluid pressure and relative viable tumour area in two human squamous cell carcinomas in nude mice during fractionated radiotherapy

AU - Baumann, M

AU - Appold, S

AU - Zimmer, J

AU - Scharf, M

AU - Beuthien-Baumann, B

AU - Dubben, H H

AU - Enghardt, W

AU - Schreiber, A

AU - Eicheler, W

AU - Petersen, C

PY - 2001/1/1

Y1 - 2001/1/1

N2 - Very little is known about the correlation between the radiobiological hypoxic fraction (rHF) and other measures of tumour oxygenation during fractionated irradiation. In the present study the rHF is determined in untreated human FaDu and GL squamous cell carcinoma in nude mice and in tumours irradiated with 10 fractions in 2 weeks and 20 fractions in 4 weeks, using tumour control as the experimental endpoint. The results were compared with measurements of the pO2, the interstitial fluid pressure (IFP) and the relative viable tumour area. In FaDu tumours the radiobiological hypoxic fractions (rHFs) before and during irradiation were not statistically different from 100%. Depending on the assumptions made for D0, the rHFs of GL tumours were between 0.2 and 4% or 30 and 53%. The median pO2 values were 2.8 mmHg for untreated FaDu tumours and 0.2 mmHg for GL tumours (p < 0.001). The median IFP values were 2.6 mmHg in FaDu and 5.3 mmHg in GL tumours (p = 0.01). No important changes in the pO2 and IFP values were observed during fractionated irradiation. The relative viable tumour area during irradiation decreased by 83% in FaDu tumours (p = 0.002) and by 54% in GL tumours (p = 0.003). It is concluded that differences in rHF exist between FaDu and GL tumours before and during fractionated irradiation and that these differences are not reflected by pO2 and IFP values and the relative viable tumour area.

AB - Very little is known about the correlation between the radiobiological hypoxic fraction (rHF) and other measures of tumour oxygenation during fractionated irradiation. In the present study the rHF is determined in untreated human FaDu and GL squamous cell carcinoma in nude mice and in tumours irradiated with 10 fractions in 2 weeks and 20 fractions in 4 weeks, using tumour control as the experimental endpoint. The results were compared with measurements of the pO2, the interstitial fluid pressure (IFP) and the relative viable tumour area. In FaDu tumours the radiobiological hypoxic fractions (rHFs) before and during irradiation were not statistically different from 100%. Depending on the assumptions made for D0, the rHFs of GL tumours were between 0.2 and 4% or 30 and 53%. The median pO2 values were 2.8 mmHg for untreated FaDu tumours and 0.2 mmHg for GL tumours (p < 0.001). The median IFP values were 2.6 mmHg in FaDu and 5.3 mmHg in GL tumours (p = 0.01). No important changes in the pO2 and IFP values were observed during fractionated irradiation. The relative viable tumour area during irradiation decreased by 83% in FaDu tumours (p = 0.002) and by 54% in GL tumours (p = 0.003). It is concluded that differences in rHF exist between FaDu and GL tumours before and during fractionated irradiation and that these differences are not reflected by pO2 and IFP values and the relative viable tumour area.

KW - Animals

KW - Body Fluids

KW - Carcinoma, Squamous Cell

KW - Cell Hypoxia

KW - Cell Survival

KW - Dose Fractionation

KW - Female

KW - Humans

KW - Hypopharyngeal Neoplasms

KW - Immunosuppression

KW - Laryngeal Neoplasms

KW - Male

KW - Mice

KW - Oxygen

KW - Oxygen Consumption

KW - Partial Pressure

KW - Pressure

KW - Radiation Tolerance

KW - Specific Pathogen-Free Organisms

KW - Tumor Cells, Cultured

KW - Whole-Body Irradiation

KW - Xenograft Model Antitumor Assays

M3 - SCORING: Journal article

C2 - 11504313

VL - 40

SP - 519

EP - 528

JO - ACTA ONCOL

JF - ACTA ONCOL

SN - 0284-186X

IS - 4

ER -