Radiobiological hypoxia, oxygen tension, interstitial fluid pressure and relative viable tumour area in two human squamous cell carcinomas in nude mice during fractionated radiotherapy
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Radiobiological hypoxia, oxygen tension, interstitial fluid pressure and relative viable tumour area in two human squamous cell carcinomas in nude mice during fractionated radiotherapy. / Baumann, M; Appold, S; Zimmer, J; Scharf, M; Beuthien-Baumann, B; Dubben, H H; Enghardt, W; Schreiber, A; Eicheler, W; Petersen, C.
in: ACTA ONCOL, Jahrgang 40, Nr. 4, 01.01.2001, S. 519-28.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - Radiobiological hypoxia, oxygen tension, interstitial fluid pressure and relative viable tumour area in two human squamous cell carcinomas in nude mice during fractionated radiotherapy
AU - Baumann, M
AU - Appold, S
AU - Zimmer, J
AU - Scharf, M
AU - Beuthien-Baumann, B
AU - Dubben, H H
AU - Enghardt, W
AU - Schreiber, A
AU - Eicheler, W
AU - Petersen, C
PY - 2001/1/1
Y1 - 2001/1/1
N2 - Very little is known about the correlation between the radiobiological hypoxic fraction (rHF) and other measures of tumour oxygenation during fractionated irradiation. In the present study the rHF is determined in untreated human FaDu and GL squamous cell carcinoma in nude mice and in tumours irradiated with 10 fractions in 2 weeks and 20 fractions in 4 weeks, using tumour control as the experimental endpoint. The results were compared with measurements of the pO2, the interstitial fluid pressure (IFP) and the relative viable tumour area. In FaDu tumours the radiobiological hypoxic fractions (rHFs) before and during irradiation were not statistically different from 100%. Depending on the assumptions made for D0, the rHFs of GL tumours were between 0.2 and 4% or 30 and 53%. The median pO2 values were 2.8 mmHg for untreated FaDu tumours and 0.2 mmHg for GL tumours (p < 0.001). The median IFP values were 2.6 mmHg in FaDu and 5.3 mmHg in GL tumours (p = 0.01). No important changes in the pO2 and IFP values were observed during fractionated irradiation. The relative viable tumour area during irradiation decreased by 83% in FaDu tumours (p = 0.002) and by 54% in GL tumours (p = 0.003). It is concluded that differences in rHF exist between FaDu and GL tumours before and during fractionated irradiation and that these differences are not reflected by pO2 and IFP values and the relative viable tumour area.
AB - Very little is known about the correlation between the radiobiological hypoxic fraction (rHF) and other measures of tumour oxygenation during fractionated irradiation. In the present study the rHF is determined in untreated human FaDu and GL squamous cell carcinoma in nude mice and in tumours irradiated with 10 fractions in 2 weeks and 20 fractions in 4 weeks, using tumour control as the experimental endpoint. The results were compared with measurements of the pO2, the interstitial fluid pressure (IFP) and the relative viable tumour area. In FaDu tumours the radiobiological hypoxic fractions (rHFs) before and during irradiation were not statistically different from 100%. Depending on the assumptions made for D0, the rHFs of GL tumours were between 0.2 and 4% or 30 and 53%. The median pO2 values were 2.8 mmHg for untreated FaDu tumours and 0.2 mmHg for GL tumours (p < 0.001). The median IFP values were 2.6 mmHg in FaDu and 5.3 mmHg in GL tumours (p = 0.01). No important changes in the pO2 and IFP values were observed during fractionated irradiation. The relative viable tumour area during irradiation decreased by 83% in FaDu tumours (p = 0.002) and by 54% in GL tumours (p = 0.003). It is concluded that differences in rHF exist between FaDu and GL tumours before and during fractionated irradiation and that these differences are not reflected by pO2 and IFP values and the relative viable tumour area.
KW - Animals
KW - Body Fluids
KW - Carcinoma, Squamous Cell
KW - Cell Hypoxia
KW - Cell Survival
KW - Dose Fractionation
KW - Female
KW - Humans
KW - Hypopharyngeal Neoplasms
KW - Immunosuppression
KW - Laryngeal Neoplasms
KW - Male
KW - Mice
KW - Oxygen
KW - Oxygen Consumption
KW - Partial Pressure
KW - Pressure
KW - Radiation Tolerance
KW - Specific Pathogen-Free Organisms
KW - Tumor Cells, Cultured
KW - Whole-Body Irradiation
KW - Xenograft Model Antitumor Assays
M3 - SCORING: Journal article
C2 - 11504313
VL - 40
SP - 519
EP - 528
JO - ACTA ONCOL
JF - ACTA ONCOL
SN - 0284-186X
IS - 4
ER -