Radiation rescue: mesenchymal stromal cells protect from lethal irradiation.
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Radiation rescue: mesenchymal stromal cells protect from lethal irradiation. / Lange, Claudia; Brunswig-Spickenheier, Bärbel; Capallo-Obermann, Heike; Eggert, Katharina; Gehling, Ursula; Rudolph, Cornelia; Schlegelberger, Brigitte; Cornils, Kerstin; Zustin, Jozef; Spiess, Andrej-Nikolai; Zander, Axel R.
In: PLOS ONE, Vol. 6, No. 1, 1, 2011, p. 14486.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Radiation rescue: mesenchymal stromal cells protect from lethal irradiation.
AU - Lange, Claudia
AU - Brunswig-Spickenheier, Bärbel
AU - Capallo-Obermann, Heike
AU - Eggert, Katharina
AU - Gehling, Ursula
AU - Rudolph, Cornelia
AU - Schlegelberger, Brigitte
AU - Cornils, Kerstin
AU - Zustin, Jozef
AU - Spiess, Andrej-Nikolai
AU - Zander, Axel R.
PY - 2011
Y1 - 2011
N2 - Successful treatment of acute radiation syndromes relies on immediate supportive care. In patients with limited hematopoietic recovery potential, hematopoietic stem cell (HSC) transplantation is the only curative treatment option. Because of time consuming donor search and uncertain outcome we propose MSC treatment as an alternative treatment for severely radiation-affected individuals.
AB - Successful treatment of acute radiation syndromes relies on immediate supportive care. In patients with limited hematopoietic recovery potential, hematopoietic stem cell (HSC) transplantation is the only curative treatment option. Because of time consuming donor search and uncertain outcome we propose MSC treatment as an alternative treatment for severely radiation-affected individuals.
KW - Animals
KW - Humans
KW - Treatment Outcome
KW - Survival Rate
KW - Cells, Cultured
KW - Mice
KW - Cell Cycle
KW - Inflammation
KW - Cell Adhesion
KW - Mesenchymal Stem Cell Transplantation/methods
KW - Acute Radiation Syndrome/metabolism/pathology/therapy
KW - Hematopoiesis
KW - Mesenchymal Stem Cells/cytology/physiology
KW - Radiation Injuries, Experimental/metabolism/pathology/therapy
KW - Radiation Protection/methods
KW - Stromal Cells/cytology/radiation effects
KW - Animals
KW - Humans
KW - Treatment Outcome
KW - Survival Rate
KW - Cells, Cultured
KW - Mice
KW - Cell Cycle
KW - Inflammation
KW - Cell Adhesion
KW - Mesenchymal Stem Cell Transplantation/methods
KW - Acute Radiation Syndrome/metabolism/pathology/therapy
KW - Hematopoiesis
KW - Mesenchymal Stem Cells/cytology/physiology
KW - Radiation Injuries, Experimental/metabolism/pathology/therapy
KW - Radiation Protection/methods
KW - Stromal Cells/cytology/radiation effects
U2 - 10.1371/journal.pone.0014486
DO - 10.1371/journal.pone.0014486
M3 - SCORING: Journal article
VL - 6
SP - 14486
JO - PLOS ONE
JF - PLOS ONE
SN - 1932-6203
IS - 1
M1 - 1
ER -