Radiation rescue: mesenchymal stromal cells protect from lethal irradiation.

Claudia Lange; Bärbel Brunswig-Spickenheier; Heike Capallo-Obermann; Katharina Eggert; Ursula Gehling; Cornelia Rudolph; Brigitte Schlegelberger; Kerstin Cornils; Jozef Zustin; Andrej-Nikolai Spiess; Axel R. Zander

doi:10.1371/journal.pone.0014486

Radiation rescue: mesenchymal stromal cells protect from lethal irradiation.

Claudia Lange
Bärbel Brunswig-Spickenheier
Heike Capallo-Obermann
Katharina Eggert
Ursula Gehling
Cornelia Rudolph
Brigitte Schlegelberger
Kerstin Cornils
Jozef Zustin
Andrej-Nikolai Spiess
Axel R. Zander

Related Research units

Department of Stem Cell Transplantation
Department of Dermatology and Venereology
Department of Visceral Transplant Surgery
Institute of Pathology

Abstract

Successful treatment of acute radiation syndromes relies on immediate supportive care. In patients with limited hematopoietic recovery potential, hematopoietic stem cell (HSC) transplantation is the only curative treatment option. Because of time consuming donor search and uncertain outcome we propose MSC treatment as an alternative treatment for severely radiation-affected individuals.

Bibliographical data

Original language	English
Article number	1
ISSN	1932-6203
DOIs	https://doi.org/10.1371/journal.pone.0014486
Publication status	Published - 2011

pubmed	21245929