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Quantitative assessment of spontaneous lung metastases of human HT29 colon cancer cells transplanted into SCID mice

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Quantitative assessment of spontaneous lung metastases of human HT29 colon cancer cells transplanted into SCID mice. / Jojovic, M; Schumacher, U.

In: CANCER LETT, Vol. 152, No. 2, 01.05.2000, p. 151-6.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Jojovic, M & Schumacher, U 2000, 'Quantitative assessment of spontaneous lung metastases of human HT29 colon cancer cells transplanted into SCID mice', CANCER LETT, vol. 152, no. 2, pp. 151-6.

APA

Jojovic, M., & Schumacher, U. (2000). Quantitative assessment of spontaneous lung metastases of human HT29 colon cancer cells transplanted into SCID mice. CANCER LETT, 152(2), 151-6.

Vancouver

Jojovic M, Schumacher U. Quantitative assessment of spontaneous lung metastases of human HT29 colon cancer cells transplanted into SCID mice. CANCER LETT. 2000 May 1;152(2):151-6.

Bibtex

@article{40009c3da9674b009077f91a523f1374,
title = "Quantitative assessment of spontaneous lung metastases of human HT29 colon cancer cells transplanted into SCID mice",
abstract = "The number of spontaneous lung metastases of the human colon cancer cell line HT29 transplanted into SCID mice was quantified. The lungs were sliced, randomly distributed in agar blocks and the number of lung metastases was counted for each of 39 animals. A nearly exponential increase of metastases with weight of the tumor at the implantation site was observed. This suggests that a critical tumor weight for the initiation of metastatic spread exists. Calculating the data, a simplified quantitative assessment of the metastatic load by counting ten histological sections only for the estimation of the total number of lung metastases is proposed.",
keywords = "Animals, Colonic Neoplasms, Female, HT29 Cells, Humans, Lung Neoplasms, Mice, Mice, Inbred BALB C, Mice, SCID, Neoplasm Transplantation, Phenotype",
author = "M Jojovic and U Schumacher",
year = "2000",
month = may,
day = "1",
language = "English",
volume = "152",
pages = "151--6",
journal = "CANCER LETT",
issn = "0304-3835",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

RIS

TY - JOUR

T1 - Quantitative assessment of spontaneous lung metastases of human HT29 colon cancer cells transplanted into SCID mice

AU - Jojovic, M

AU - Schumacher, U

PY - 2000/5/1

Y1 - 2000/5/1

N2 - The number of spontaneous lung metastases of the human colon cancer cell line HT29 transplanted into SCID mice was quantified. The lungs were sliced, randomly distributed in agar blocks and the number of lung metastases was counted for each of 39 animals. A nearly exponential increase of metastases with weight of the tumor at the implantation site was observed. This suggests that a critical tumor weight for the initiation of metastatic spread exists. Calculating the data, a simplified quantitative assessment of the metastatic load by counting ten histological sections only for the estimation of the total number of lung metastases is proposed.

AB - The number of spontaneous lung metastases of the human colon cancer cell line HT29 transplanted into SCID mice was quantified. The lungs were sliced, randomly distributed in agar blocks and the number of lung metastases was counted for each of 39 animals. A nearly exponential increase of metastases with weight of the tumor at the implantation site was observed. This suggests that a critical tumor weight for the initiation of metastatic spread exists. Calculating the data, a simplified quantitative assessment of the metastatic load by counting ten histological sections only for the estimation of the total number of lung metastases is proposed.

KW - Animals

KW - Colonic Neoplasms

KW - Female

KW - HT29 Cells

KW - Humans

KW - Lung Neoplasms

KW - Mice

KW - Mice, Inbred BALB C

KW - Mice, SCID

KW - Neoplasm Transplantation

KW - Phenotype

M3 - SCORING: Journal article

C2 - 10773406

VL - 152

SP - 151

EP - 156

JO - CANCER LETT

JF - CANCER LETT

SN - 0304-3835

IS - 2

ER -