Quantitative assessment of spontaneous lung metastases of human HT29 colon cancer cells transplanted into SCID mice
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Quantitative assessment of spontaneous lung metastases of human HT29 colon cancer cells transplanted into SCID mice. / Jojovic, M; Schumacher, U.
in: CANCER LETT, Jahrgang 152, Nr. 2, 01.05.2000, S. 151-6.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Quantitative assessment of spontaneous lung metastases of human HT29 colon cancer cells transplanted into SCID mice
AU - Jojovic, M
AU - Schumacher, U
PY - 2000/5/1
Y1 - 2000/5/1
N2 - The number of spontaneous lung metastases of the human colon cancer cell line HT29 transplanted into SCID mice was quantified. The lungs were sliced, randomly distributed in agar blocks and the number of lung metastases was counted for each of 39 animals. A nearly exponential increase of metastases with weight of the tumor at the implantation site was observed. This suggests that a critical tumor weight for the initiation of metastatic spread exists. Calculating the data, a simplified quantitative assessment of the metastatic load by counting ten histological sections only for the estimation of the total number of lung metastases is proposed.
AB - The number of spontaneous lung metastases of the human colon cancer cell line HT29 transplanted into SCID mice was quantified. The lungs were sliced, randomly distributed in agar blocks and the number of lung metastases was counted for each of 39 animals. A nearly exponential increase of metastases with weight of the tumor at the implantation site was observed. This suggests that a critical tumor weight for the initiation of metastatic spread exists. Calculating the data, a simplified quantitative assessment of the metastatic load by counting ten histological sections only for the estimation of the total number of lung metastases is proposed.
KW - Animals
KW - Colonic Neoplasms
KW - Female
KW - HT29 Cells
KW - Humans
KW - Lung Neoplasms
KW - Mice
KW - Mice, Inbred BALB C
KW - Mice, SCID
KW - Neoplasm Transplantation
KW - Phenotype
M3 - SCORING: Journal article
C2 - 10773406
VL - 152
SP - 151
EP - 156
JO - CANCER LETT
JF - CANCER LETT
SN - 0304-3835
IS - 2
ER -